Purine and Pyrimidine Metabolism -- Contents -- Chairman's opening remarks -- Purine and pyrimidine metabolism : pathways, pitfalls and perturbations -- Discussion -- Microbial models and regulatory elements in the control of purine metabolism -- Discussion -- Molecular nature of enzyme regulation in purine biosynthesis -- Discussion -- Genetic heterogeneity at the locus for hypoxanthine-guanine phosphoribosyltransferase -- Discussion -- Factors in the pathogenesis of the brain damage and anaemia in the Lesch-Nyhan syndrome -- Discussion -- Hypoxanthine-guanine phosphoribosyltransferase activity in individual erythrocytes: autoradiographic studies in heterozygot -- Discussion -- Purine biosynthesis in mutant mammalian cells -- Discussion -- Purine and pyrimidine nucleotides in some mutant human lymphoblasts -- Discussion -- Superactivity of phosphoribosylpyrophosphate synthetase, due to feedback resistance, causing purine overproduction and gout -- Discussion -- Dietary feedback regulation of purine and pyrimidine biosynthesis in man -- Discussion -- Implications of disorders of purine metabolism for the kidney and the urinary tract -- Discussion -- The role of de novo purine synthesis in lymphocyte transformation -- Discussion -- Purine metabolism and control of cell proliferation -- Discussion -- The effect of adenosine on lymphoid cell proliferation and antibody formation -- Discussion -- Characterization of human adenosine deaminase -- Discussion -- The purinergic nerve hypothesis -- Discussion -- Inherited metabolic disease: prospects for the future in both basic and clinical research -- Discussion -- General discussion -- Purine as regulators -- Extracellular effects of adenosine -- Membrane transport -- Pyrimidine metabolism and immune function -- Allopurinol and purine transport.

Model systems for the study of purine and pyrimidine metabolism and their limitations -- Animal models -- Assessment of treatment : the Lesch-Nyhan syndrome -- Ribose 5-phosphate and the oxidative pentose shunt in the regulation of purine synthesis de novo -- Index of contributors -- Subject index.