Acute Exposure Guideline Levels for Selected Airborne Chemicals -- Copyright -- OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY -- Preface -- Contents -- Introduction -- SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING AEGLS -- Roster of the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances -- Appendix -- 1 Phosgene: Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Case Reports -- 2.2.2. Epidemiologic Studies -- 2.3. Developmental and Reproductive Toxicity -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Mouse -- 3.1.2. Rats -- 3.1.3. Guinea Pigs -- 3.1.4. Rabbits -- 3.1.5. Cats -- 3.1.6. Dogs -- 3.1.7. Goats -- 3.1.8. Sheep -- 3.1.9. Nonhuman Primates -- 3.2. Nonlethal Toxicity -- 3.2.1. Mice -- 3.2.2. Rats -- 3.2.3. Guinea Pigs -- 3.2.4. Hamsters -- 3.2.5. Rabbits -- 3.2.6. Dogs -- 3.2.7. Sheep -- 3.2.8. Goats -- 3.2.9. Cats -- 3.2.10. Monkeys -- 3.3. Developmental and Reproductive Toxicity -- 3.4. Genotoxicity -- 3.5. Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Haber's Law and Time Scaling -- 5. RATIONALE AND PROPOSED AEGL-1 -- 5.1. Human Data Relevant to AEGL-1 -- 5.2. Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. RATIONALE AND PROPOSED AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. RATIONALE AND PROPOSED AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF PROPOSED AEGLS.

8.1. AEGL Values and Toxicity End Points -- 8.2. Comparison with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendixes -- APPENDIX A DERIVATION OF AEGL VALUES -- Derivation of AEGL-1 -- Derivation of AEGL-2 -- Derivation of AEGL-3 -- APPENDIX B DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR PHOSGENE (CAS No. 75-44-5) -- 2 Propylene Glycol Dinitrate: Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Occupational Exposures -- 2.2.2. Experimental Studies -- 2.3. Neurotoxicity -- 2.4. Developmental and Reproductive Effects -- 2.5. Genotoxicity -- 2.6. Carcinogenicity -- 2.7. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Dogs -- 3.2.3. Rats -- 3.2.4. Guinea pigs -- 3.3. Neurotoxicity -- 3.4. Developmental and Reproductive Effects -- 3.5. Genotoxicity -- 3.6. Chronic Toxicity and Carcinogenicity -- 3.7. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanisms of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Differences -- 4.4.2. Susceptible Populations -- 4.4.3. Concentration-Exposure Duration Relationship -- 4.4.4. Concurrent Exposures -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Summary of Human Data Relevant to AEGL-1 -- 5.2. Summary of Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Summary of Human Data Relevant to AEGL-2 -- 6.2. Summary of Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS FOR AEGL-3 -- 7.1. Summary of Human Data Relevant to AEGL-3 -- 7.2. Summary of Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF AEGLs.

8.1. AEGL Values and Toxicity End points -- 8.2. Comparisons with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendixes -- APPENDIX A DERIVATION OF AEGL VALUES -- Derivation of AEGL-1 -- Derivation of AEGL-2 -- Derivation of AEGL-3 -- APPENDIX B Potential Methemoglobin Formation in Infants -- APPENDIX C DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS PROPYLENE GLYCOL DINITRATE (CAS No… -- 3 1,1,1,2-Tetrafluoroethane (HFC-134a): Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.3. Neurotoxicity -- 2.4. Developmental and Reproductive Toxicity -- 2.5. Genotoxicity -- 2.6. Carcinogenicity -- 2.7. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Dogs -- 3.2.3. Rats -- 3.2.4. Mice -- 3.3. Neurotoxicity -- 3.4. Developmental and Reproductive Toxicity -- 3.5. Cardiac Sensitization -- 3.6. Genotoxicity -- 3.7. Subchronic and Chronic Toxicity and Carcinogenicity -- 3.8. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition Considerations -- 4.1.1. Deposition and Elimination -- 4.1.2. Metabolism -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Differences -- 4.4.2. Susceptible Populations -- 4.4.3. Concentration-Exposure Duration Relationship -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Summary of Human Data Relevant to AEGL-1 -- 5.2. Summary of Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Summary of Human Data Relevant to AEGL-2 -- 6.2. Summary of Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS FOR AEGL-3 -- 7.1. Summary of Human Data Relevant to AEGL-3.

7.2. Summary of Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF AEGLs -- 8.1. AEGL Values and Toxicity End points -- 8.2. Comparison with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendix -- DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR 1,1,1,2-TETRAFLUOROETHANE (HCF-134a) (CAS No. 811-97-2) -- 4 1,1-Dichloro-1-fluoroethane (HCFC-141b): Acute Exposure Guideline Levels -- SUMMARY -- 1. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.2.1. Occupational Exposures -- 2.2.2. Experimental Studies -- 2.3. Neurotoxicity -- 2.4. Developmental and Reproductive Toxicity -- 2.5. Genotoxicity -- 2.6. Carcinogenicity -- 2.7. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Rats -- 3.1.2. Mice -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.2. Dogs -- 3.2.3. Rats -- 3.2.4. Mice -- 3.3. Neurotoxicity -- 3.4. Developmental and Reproductive Toxicity -- 3.5. Cardiac Sensitization -- 3.6. Genotoxicity -- 3.7. Chronic Toxicity and Carcinogenicity -- 3.8. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition Considerations -- 4.1.1. Deposition -- 4.1.2. Metabolism -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Variability -- 4.4.2. Susceptible Populations -- 4.4.3. Concentration-Exposure Duration Relationship -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Summary of Human Data Relevant to AEGL-1 -- 5.2. Summary of Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Summary of Human Data Relevant to AEGL-2 -- 6.2. Summary of Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS FOR AEGL-3 -- 7.1. Summary of Human Data Relevant to AEGL-3.

7.2. Summary of Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF AEGLs -- 8.1. AEGL Values and Toxicity End Points -- 8.2. Comparison with Other Standards and Guidelines -- 8.3. Data Adequacy and Research Needs -- 9. REFERENCES -- Appendix -- DERIVATION SUMMARY FOR ACUTE EXPOSURE GUIDELINE LEVELS FOR 1,1-DICHLORO-1-FLUOROETHANE (HCFC-141b) ( CAS No. 1717-00-6) -- 5 Hydrogen Cyanide: Acute Exposure Guideline Levels -- SUMMARY -- I. INTRODUCTION -- 2. HUMAN TOXICITY DATA -- 2.1. Acute Lethality -- 2.2. Nonlethal Toxicity -- 2.3. Developmental and Reproductive Effects -- 2.4. Genotoxicity -- 2.5. Carcinogenicity -- 2.6. Summary -- 3. ANIMAL TOXICITY DATA -- 3.1. Acute Lethality -- 3.1.1. Dogs -- 3.1.2. Rats -- 3.1.3. Mice -- 3.1.4. Rabbits -- 3.2. Nonlethal Toxicity -- 3.2.1. Nonhuman Primates -- 3.2.4. Mice -- 3.2.5. Rabbits -- 3.3. Developmental and Reproductive Effects -- 3.4. Genotoxicity -- 3.5. Chronic Toxicity and Carcinogenicity -- 3.6. Summary -- 4. SPECIAL CONSIDERATIONS -- 4.1. Metabolism and Disposition -- 4.2. Mechanism of Toxicity -- 4.3. Structure-Activity Relationships -- 4.4. Other Relevant Information -- 4.4.1. Species Differences -- 4.4.2. Susceptible Populations -- 4.4.3. Concentration-Exposure Duration Relationship -- 4.4.4. Concurrent Exposure Issues -- 5. DATA ANALYSIS FOR AEGL-1 -- 5.1. Human Data Relevant to AEGL-1 -- 5.2. Animal Data Relevant to AEGL-1 -- 5.3. Derivation of AEGL-1 -- 6. DATA ANALYSIS FOR AEGL-2 -- 6.1. Human Data Relevant to AEGL-2 -- 6.2. Animal Data Relevant to AEGL-2 -- 6.3. Derivation of AEGL-2 -- 7. DATA ANALYSIS FOR AEGL-3 -- 7.1. Human Data Relevant to AEGL-3 -- 7.2. Animal Data Relevant to AEGL-3 -- 7.3. Derivation of AEGL-3 -- 8. SUMMARY OF AEGLs -- 8.1. AEGL Values and Toxicity End Points -- 8.2. Comparisons with Other Standards and Guidelines.

8.3. Data Adequacy and Research Needs.