Front Matter -- Reviewers -- Preface -- Acknowledgments -- Contents -- Tables, Figures, and Boxes -- Abstract -- Summary -- Part I The U.S. Global AIDS Initiative -- 1 Introduction -- 2 The U.S. Global AIDS Initiative: Context and Background -- Part II Progress on the First 5-Year Strategy-PEPFAR -- 3 PEPFAR's Management -- 4 PEPFAR's Prevention Category -- 5 PEPFAR's Treatment Category -- 6 PEPFAR's Care Category -- 7 PEPFAR's Orphans and Other Vulnerable Children Category -- Part III Looking to the Future -- 8 Toward Sustainability -- Appendixes -- Appendix A: Acknowledgments -- Appendix B: Methods -- Appendix C: Plan for a Short-term Evaluation of PEPFAR Implementation Letter Report # 1 -- Appendix D: Selected Bibliography for 25-Year Overview of Global HIV/AIDS -- Appendix E: Abbreviations and Acronyms -- Appendix F: Committee and Staff Biographies -- Appendix G: Information-Gathering Meeting Agendas -- Index.