Identify improvements in technology and other approaches that will ensure the future development and supply of radionuclides and radiopharmaceuticals for diagnostics imaging and therapy -- Develop a transformational fuel for light water reactors- advanced and current -- Develop innovative approaches to make special nuclear materials (SNMs) more easily monitored and more detectable if stolen -- Design and fund a 3 year public private initiative to better understand and bridge the perception/reality gap between the public and nuclear experts on the risks of the nuclear enterprise and to restore the public trust -- Define the means to promote U.S. interests in the international nuclear power field in an era of diminishing U.S. and Western European influence -- How might the widespread use of civilian nuclear power and associated fuel cycle facilities be made compatible with a world free of (or with a small number of) nuclear weapons? -- Identify a new and practical application of nuclear phenomena for the benefit of humankind.