This double volumes LNCS 11229-11230 constitutes the refereed proceedings of the Confederated International Conferences: Cooperative Information Systems, CoopIS 2018, Ontologies, Databases, and Applications of Semantics, ODBASE 2018, and Cloud and Trusted Computing, C&TC, held as part of OTM 2018 in October 2018 in Valletta, Malta. The 64 full papers presented together with 22 short papers were carefully reviewed and selected from 173 submissions. The OTM program every year covers data and Web semantics, distributed objects, Web services, databases, information systems, enterprise workflow and collaboration, ubiquity, interoperability, mobility, grid and high-performance computing.