Synthesis, characterization and investigation of cytotoxic effects of drug loaded zif-8 metal-organic frameworks
by
Mete, Derya, author.
Title
:
Synthesis, characterization and investigation of cytotoxic effects of drug loaded zif-8 metal-organic frameworks
Author
:
Mete, Derya, author.
Personal Author
:
Mete, Derya, author.
Physical Description
:
xii, 124 leaves: charts;+ 1 computer laser optical disc.
Abstract
:
The biocompatible ZIF-8 intelligent material, a member of the metal-organic framework family, has a biodegradable property in an acidic environment due to its poor coordination bonds. Because cancerous cells are more acidic than healthy cells, our studies aim to ensure that doxorubicin, sorafenib, and apalutamide, encapsulated in ZIF8, target cancer cells responsive to pH, thereby reducing damage to healthy cells. In addition, ZIF-8 was selected not only as a carrier system but also as a therapeutic effect. Because ZIF-8 material is biodegradable, it is divided into zinc and 2-methylimidazole components in cancer cells. Research shows that the decrease in the amount of zinc is essential in the formation of cancer cells. Zinc is reported to be in lower intracellular concentrations in HCC and prostate cell lines instead of healthy variants. It aims to create dual cytotoxic effects on cancer cells by combining the effects of zinc-drug on a single platform.
Subject Term
:
Metal-organic frameworks
Added Author
:
Şanlı Mohamed, Gülşah,
Added Corporate Author
:
İzmir Institute of Technology. Chemistry.
Added Uniform Title
:
Thesis (Doctoral)--İzmir Institute of Technology: Chemistry
İzmir Institute of Technology: Chemistry--Thesis (Doctoral).
Electronic Access
:
Library | Material Type | Item Barcode | Shelf Number | Status |
---|
IYTE Library | Thesis | T002463 | QD411 .M589 2021 | Tez Koleksiyonu |
IYTE Library | Supplementary CD-ROM | ROM3625 | QD411 .M589 2021 EK.1 | Tez Koleksiyonu |