Having a positive outlook translates into a happier and healthier life—and it’s not as elusive as you might think. Though there is evidence that optimism has biological and genetic roots, research has shown that we can shape our attitude to see the best possible outcomes in life, cultivating happiness, gratitude, and resilience while reducing stress and anxiety. And for those who may see the glass as half full, it is possible that pessimistic thinking can actually lead to positive outcomes. This special issue looks at the benefits of an optimistic mindset in all aspects of life, how to frame everyday thoughts in a favorable light, and how to maximize positive inclinations.