Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
by
 
Han, Ye

Title
: 
Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Author
: 
Han, Ye

Personal Author
: 
Han, Ye

Publication Information
: 
Cambridge, MA MyJoVE Corp 2016

Physical Description
: 
online resource (620 seconds)

Series
: 
Biochemistry

General Note
: 
Title from resource description page

Abstract
: 
The interaction between HCN channels and their auxiliary subunit has been identified as a therapeutic target in Major Depressive Disorder. Here, a fluorescence polarization-based method for identifying small molecule inhibitors of this protein-protein interaction, is presented.

Reading Level
: 
For undergraduate, graduate, and professional students

Subject Term
: 
Biochemistry

Electronic Access
: 
https://www.jove.com/t/54540


LibraryMaterial TypeItem BarcodeShelf NumberStatus
IYTE LibraryOnline Video2253235-1001XX(2253235.1)JoVe Video Online