Selenium: A historical perspective -- Selenium: A historical perspective -- Biosynthesis of selenocysteine and its incorporation into protein -- Selenium metabolism in prokaryotes -- Mammalian and other eukaryotic selenocysteine tRNAs -- Evolution of selenocysteine decoding and the key role of selenophosphate synthetase in the pathway of selenium utilization -- SECIS RNAs and K-turn binding proteins. A survey of evolutionary conserved RNA and protein motifs -- SECIS binding proteins and eukaryotic selenoprotein synthesis -- The importance of subcellular localization of SBP2 and EFsec for selenoprotein synthesis -- Selenocysteine biosynthesis and incorporation may require supramolecular complexes -- Selenium-containing proteins -- Selenoproteins and selenoproteomes -- Deletion of selenoprotein P gene in the mouse -- Selenium and methionine sulfoxide reduction -- Selenoprotein W in development and oxidative stress -- The 15-kDa selenoprotein (Sep15): functional analysis and role in cancer -- Regulation of glutathione peroxidase-1 expression -- Selenoproteins of the glutathione system -- New roles of glutathione peroxidase-1 in oxidative stress and diabetes -- Selenoproteins of the thioredoxin system -- Mitochondrial and cytosolic thioredoxin reductase knockout mice -- Selenium, deiodinases and endocrine function -- Biotechnology of selenocysteine -- Selenium and human health -- Selenium, selenoproteins and brain function -- Selenium as a cancer preventive agent -- Peering down the kaleidoscope of thiol proteomics and unfolded protein response in studying the anticancer action of selenium -- Genetic variation among selenoprotein genes and cancer -- Selenium and viral infections -- Role of selenium in HIV/AIDS -- Effects of selenium on immunity and aging -- Selenium and male reproduction -- Mouse models for assessing the role of selenoproteins in health and development -- Drosophila as a tool for studying selenium metabolism and role of selenoproteins -- Selenoproteins in parasites -- Incorporating ‘omics’ approaches to elucidate the role of selenium and selenoproteins in cancer prevention -- Selenium-induced apoptosis -- Selenoprotein mimics -- Update of human dietary standards for selenium.