APL as a Paradigm in Biomedical Research: A Journey Toward the Cure -- Mouse Models of Acute Promyelocytic Leukemia -- The PLZF Gene of t(11;17)-Associated APL -- SUMO, the Three Rs and Cancer -- Emerging Role for MicroRNAs in Acute Promyelocytic Leukemia -- The Theory of APL Revisited -- Treatment of Acute Promyelocytic Leukemia by Retinoids -- Arsenic Trioxide and Acute Promyelocytic Leukemia: Clinical and Biological -- Front Line Clinical Trials and Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia -- Histone Deacetylase Inhibitors in APL and Beyond -- Monoclonal Antibody Therapy of APL -- Targeting APL Fusion Proteins by Peptide Interference -- The Design of Selective and Non-selective Combination Therapy for Acute Promyelocytic Leukemia.