Preclinical Part -- Biological Basis of Combined Radio- and Chemotherapy -- Combinations of Antimetabolites and Ionizing Radiation -- Combinations of Taxanes and Ionizing Radiation -- Combinations of Topoisomerase Inhibitors and Ionizing Radiation -- Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation -- Combinations of Platinum Compounds and Ionizing Radiation -- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Angiogenesis Inhibitors -- Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors -- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors -- Combinations of Ionizing Radiation and Other Sensitizing Agents -- Radiotherapy and Tumor-Targeted Drug Delivery -- Clinical Part -- Applications in Malignant Brain Tumors -- Applications in Head and Neck Cancer -- Applications in Esophageal and Gastric Cancer -- Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies -- Applications in Lung Cancer -- Integration of Radiation Therapy and Systemic Therapy for Breast Cancer -- Applications in Rectal and Anal Cancer -- Concomitant Radiation and Chemotherapy in Muscle-Invasive Bladder Cancer -- Applications to Gynecological Cancers -- Early and Late Treatment-Induced Toxicity -- Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients.