The integration of creative, imaginative and economically feasible structures into the design process of _buildings has always been an essential issue in the history of architecture. The aim of this study is; to explore the relationship between the design of structural systems and the formation of architectural space, to display the changes in structure/space relationship in respect to scientific progress from the beginning of the age of positivism until today. This study is structured in two parts. At first, a morphological classification is made within a retrospective overview to explore the relationship of structure and space. Secondly, the age of positivism and the effects of positivism on architectural theories are explored to determine the changes in structure/space relationship. Today, the new developments in architectural space concept, such as "dynamic stability" affects the design of structures. Still, it is clear that the structure is an indispensable necessity during the process of shaping the space and architectural end product "building", whether the space is static or dynamic.