DRUG DISCOVERY HANDBOOK -- CONTRIBUTORS -- CONTENTS -- Preface -- Introduction: Drug Discovery in the 21(st) Century -- 1 Natural Products -- 2 Cancer Cell Proteomics Using Molecular Aptamers -- 3 Molecular Similarity Methods and QSAR Models as Tools for Virtual Screening -- 4 Systems Biology: Applications in Drug Discovery -- 5 High-Throughput Flow Cytometry -- 6 Combining NMR Spectral Information with Associated Structural Features to Form Computationally Nonintensive, Rugged, and Objective Models of Biological Activity -- 7 Using Microsoft Excel® as a Laboratory Data Management Tool -- 8 Age of Regulation -- 9 Simultaneous Screening of Multiple Cell Lines Using the CellCard System -- 10 Protein X-ray Crystallography in Drug Discovery -- 11 Biological and Chemistry Assays Available During Drug Discovery and Developability Assessment -- 12 Strategies and Methods in Monitoring and Targeting Protein-Protein Interactions -- 13 High-Throughput Screening: Evolution of Technology and Methods -- 14 Metal-Enhanced Fluorescence: Application to High-Throughput Screening and Drug Discovery -- 15 Methods for the Design and Analysis of Replicate-Experiment Studies to Establish Assay Reproducibility and the Equivalence of Two Potency Assays -- 16 Coupled Luminescent Methods in Drug Discovery: 3-Min Assays for Cytotoxicity and Phosphatase Activity -- 17 Design and Pharmaceutical Applications of Prodrugs -- 18 GABA and Glutamate Receptor Ligands and Their Therapeutic Potential in CNS Disorders -- 19 Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists: Novel Ischemia-Selective Antiarrhythmic Agents -- 20 Factors Influencing the Efficacy of Mediator-Specific Anti-Inflammatory, Glucocorticoid, and Anticoagulant Therapies for Sepsis -- 21 Combinatorial Chemistry in the Drug Discovery Process.

22 Herbal Medicines and Animal Models of Gastrointestinal Diseases -- 23 Endocrine and Metabolic Agents -- 24 Respiratory Viruses -- 25 Strategies in the Design of Antiviral Drugs -- 26 Protein Kinase Inhibitors in Drug Discovery -- 27 RNA-Based Therapies -- 28 Novel Imaging Agents for Molecular MR Imaging of Cancer -- 29 Targets and Approches for Cancer Drug Discovery -- Index.