Cover image for Lectures On Statistical Physics And Protein Folding.
Lectures On Statistical Physics And Protein Folding.
Title:
Lectures On Statistical Physics And Protein Folding.
Author:
Huang, Kerson.
ISBN:
9789812569387
Personal Author:
Physical Description:
1 online resource (159 pages)
Contents:
Contents -- Foreword -- Introduction -- 1. Entropy -- 1.1 Statistical Ensembles -- 1.2 Microcanonical Ensemble and Entropy -- 1.3 Thermodynamics -- 1.4 Principle of Maximum Entropy -- 1.5 Example: Defects in Solid -- 2. Maxwell-Boltzmann Distribution -- 2.1 Classical Gas of Atoms -- 2.2 The Most Probable Distribution -- 2.3 The Distribution Function -- 2.4 Thermodynamic Properties -- 3. Free Energy -- 3.1 Canonical Ensemble -- 3.2 Energy Fluctuations -- 3.3 The Free Energy -- 3.4 Maxwell's Relations -- 3.5 Example: Unwinding of DNA -- 4. Chemical Potential -- 4.1 Changing the Particle Number -- 4.2 Grand Canonical Ensemble -- 4.3 Thermodynamics -- 4.4 Critical Fluctuations -- 4.5 Example: Ideal Gas -- 5. Phase Transitions -- 5.1 First-Order Phase Transitions -- 5.2 Second-Order Phase Transitions -- 5.3 Van der Waals Equation of State -- 5.4 Maxwell Construction -- 6. Kinetics of Phase Transitions -- 6.1 Nucleation and Spinodal Decomposition -- 6.2 The Freezing of Water -- 7. The Order Parameter -- 7.1 Ginsburg-Landau Theory -- 7.2 Second-Order Phase Transition -- 7.3 First-Order Phase Transition -- 7.4 Cahn-Hilliard Equation -- 8. Correlation Function -- 8.1 Correlation Length -- 8.2 Large-Distance Correlations -- 8.3 Universality Classes -- 8.4 Compactness Index -- 8.5 Scaling Properties -- 9. Stochastic Processes -- 9.1 Brownian Motion -- 9.2 Random Walk -- 9.3 Diffusion -- 9.4 Central Limit Theorem -- 9.5 Diffusion Equation -- 10. Langevin Equation -- 10.1 The Equation -- 10.2 Solution -- 10.3 Fluctuation-Dissipation Theorem -- 10.4 Power Spectrum and Correlation -- 10.5 Causality -- 10.6 Energy Balance -- 11. The Life Process -- 11.1 Life -- 11.2 Cell Structure -- 11.3 Molecular Interactions -- 11.4 Primary Protein Structure -- 11.5 Secondary Protein Structure -- 11.6 Tertiary Protein Structure -- 11.7 Denatured State of Protein.

12. Self-Assembly -- 12.1 Hydrophobic Effect -- 12.2 Micelles and Bilayers -- 12.3 Cell Membrane -- 12.4 Kinetics of Self-Assembly -- 12.5 Kinetic Arrest -- 13. Kinetics of Protein Folding -- 13.1 The Statistical View -- 13.2 Denatured State -- 13.3 Molten Globule -- 13.4 Folding Funnel -- 13.5 Convergent Evolution -- 14. Power Laws in Protein Folding -- 14.1 The Universal Range -- 14.2 Collapse and Annealing -- 14.3 Self-Avoiding Walk (SAW) -- 15. Self-Avoiding Walk and Turbulence -- 15.1 Kolmogorov's Law -- 15.2 Vortex Model -- 15.3 Quantum Turbulence -- 15.4 Convergent Evolution in Turbulence -- 16. Convergent Evolution in Protein Folding -- 16.1 Mechanism of Convergent Evolution -- 16.2 Energy Cascade in Turbulence -- 16.3 Energy Cascade in the Polymer Chain -- 16.4 Energy Cascade in the Molten Globule -- 16.5 Secondary and Tertiary Structures -- A. Model of Energy Cascade in a Protein Molecule -- A.1 Brownian Motion of a Forced Harmonic Oscillator -- A.2 Coupled Oscillators -- A.2.1 Equations of Motion -- A.2.2 Energy Balance -- A.2.3 Fluctuation-Dissipation Theorem -- A.2.4 Perturbation Theory -- A.2.5 Weak-Damping Approximation -- A.3 Model of Protein Dynamics -- A.4 Fluctuation-Dissipation Theorem -- A.5 The Cascade Time -- A.6 Numerical Example -- Index.
Abstract:
This book introduces an approach to protein folding from the point ofview of kinetic theory. There is an abundance of data on proteinfolding, but few proposals are available on the mechanism driving theprocess. Here, presented for the first time, are suggestions onpossible research directions, as developed by the author incollaboration with C C Lin.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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