Cover -- Half-title -- Series-title -- Title -- Copyright -- Contents -- Figures -- Acknowledgements -- 1 Personalised medicine - A revolution in healthcare -- Politics -- Terminology -- Interviews -- Themes and structure -- 2 Pharmacogenetics, expectation and promissory science -- A brief history of pharmacogenetics -- Industry -- Constructing a pharmacogenomic future -- How to create expectations -- Case Studies in pharmacogenetic's and the clinic -- Alzheimer's disease -- Breast cancer -- Conclusion -- 3 Genetics, moral risk and professional resistance -- Origins of APOE -- Consensus and debate -- Building support -- Systems of resistance -- Status quo -- Conclusion -- 4 Clinical resistance to Alzheimer's pharmacogenetics -- Resistance at the coalface -- Second generation -- Sources of resistance -- Distrust in numbers -- Conclusion -- 5 Research, industry and pharmacogenetic literacy -- APOE testing in research and the clinic -- Follow the money -- The politics of APOE -- Deficits and resistance -- Conclusion -- 6 Engineering the clinic - getting personalised medicine into practice -- Herceptin, breast cancer and drugs -- Testing cultures -- Reference centres -- Expanding access -- Conclusion -- 7 The fourth hurdle - cost-effectiveness and the funding of pharmacogenetics -- The structure of the NHS -- Robbing Peter: controlling healthcare expenditure -- NICE -- The politics of Herceptin appraisal -- Funding personalised medicine -- Conclusion -- 8 Disappointment and disclosure in the pharmacogenetic clinic -- Pharmacogenetics in the clinic -- Everyday testing -- Informing patients -- Disappointment -- Ethical issues in Herceptin use -- Conclusion -- 9 The personalised is political -- Ordinary coalface knowledge -- Promises and realities -- Bibliography -- Index.