
The Implicit Genome.
Title:
The Implicit Genome.
Author:
Caporale, Lynn Helena.
ISBN:
9780195346725
Personal Author:
Physical Description:
1 online resource (398 pages)
Contents:
Contents -- Contributors -- An Overview of the Implicit Genome -- 1. Sequence-Dependent Properties of DNA and Their Role in Function -- 2. Mutation as a Phenotype -- 3. Repeats and Variation in Pathogen Selection -- 4. Tuning Knobs in the Genome: Evolution of Simple Sequence Repeats by Indirect Selection -- 5. Implicit Information in Eukaryotic Pathogens as the Basis of Antigenic Variation -- 6. The Role of Repeat Sequences in Bacterial Genetic Adaptation to Stress -- 7. The Role of Mobile DNA in the Evolution of Prokaryotic Genomes -- 8. Eukaryotic Transposable Elements: Teaching Old Genomes New Tricks -- 9. Immunoglobulin Recombination Signal Sequences: Somatic and Evolutionary Functions -- 10. Somatic Evolution of Antibody Genes -- 11. Regulated and Unregulated Recombination of G-rich Genomic Regions -- 12. The Role of the Genome in the Initiation of Meiotic Recombination -- 13. Nuclear Duality and the Genesis of Unusual Genomes in Ciliated Protozoa -- 14. Editing Informational Content of Expressed DNA Sequences and Their Transcripts -- 15. Alternative Splicing: One Gene, Many Products -- 16. Imprinting: The Hidden Genome -- Epilogue: An Engineering Perspective: The Implicit Protocols -- References -- List of Acronyms -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.
Abstract:
In its beautiful simplicity, the double-helicaln stucture of DNA had entranced us into believing that we can fully understand the information content of a DNA sequence, simply by treating it as text that is read in a linear fashion. While we have learned much based on this assumption, there is much we have missed. Far from a passive tape running through a reader, genomes contain information that appears in new forms which create regions with distinct behavior. The chapters in this volume touch on one or more of three interconnected themes; information can be implied, rather than explicit, in a genome; information can lead to focused and/or regulated changes in nucleotide sequences; information that affects the probability of distinct classes of mutation has implications for evolutionary theory.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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