Front Cover -- Veterinary Toxicology -- Copyright Page -- Contents -- Foreword -- Preface -- List of Contributors -- Part 1 General -- Chapter 1 Concepts in veterinary toxicology -- INTRODUCTION -- HISTORICAL PERSPECTIVE -- EVOLUTION OF VETERINARY TOXICOLOGY -- A FRAMEWORK FOR ACQUIRING INFORMATION -- SOURCES OF INFORMATION -- SCHEMATIC EXPERIMENTAL DESIGNS -- TOXICOLOGICAL DESCRIPTORS -- CONCLUSIONS AND SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 2 Pharmacokinetics and toxicokinetics: fundamentals and applications in toxicology -- INTRODUCTION -- FUNDAMENTALS OF XENOBIOTIC DISPOSITION -- ABSORPTION -- NON-ORAL ROUTES AND XENOBIOTIC ABSORPTION -- INHALATION -- SPECIES DIFFERENCES IN ABSORPTION -- DISTRIBUTION -- METABOLISM AND ELIMINATION -- CLASSICAL TOXICOKINETIC MODELS -- FUNDAMENTAL NON-COMPARTMENTAL TOXICOKINETIC PARAMETERS -- BIOAVAILABILITY -- CLASSICAL PLASMA/TISSUE TOXICOKINETICS: APPLICATIONS IN DRUG DISCOVERY AND DRUG DEVELOPMENT -- APPLICATIONS OF ADME AND TOXICOKINETICS IN DRUG DISCOVERY AND DEVELOPMENT -- SPECIES SELECTION FOR TERATOGENICITY -- DOSE SELECTION FOR PRECLINICAL EARLY DOSE RANGE-FINDING TOXICITY STUDIES -- DOSE SELECTION FOR REPEATED DOSE TOXICITY STUDIES -- CARCINOGENICITY BIOASSAY STUDIES IN RODENTS -- CONCLUSIONS -- REFERENCES -- Chapter 3 Physiologically based pharmacokinetic modeling -- INTRODUCTION -- BACKGROUND -- MODEL CONSTRUCTION -- PARAMETER ESTIMATION AND IDENTIFIABILITY -- MODEL VALIDATION -- APPLICATIONS -- CONCLUSIONS -- REFERENCES -- Chapter 4 Toxicological testing: in vivo and in vitro models -- INTRODUCTION -- IN VIVO MODELS IN TOXICITY TESTING -- IN VITRO MODELS OF TOXICITY TESTING -- GENERAL SUMMARY AND CONCLUSIONS -- REFERENCES -- Chapter 5 Epidemiology of animal poisonings -- INTRODUCTION -- DEMOGRAPHICS -- DOGS -- CATS -- OTHER SPECIES -- AGENTS INVOLVED -- SIGNS AND OUTCOMES.

CONCLUSIONS -- REFERENCES -- Chapter 6 Chemicals of terrorism -- INTRODUCTION -- CHLORINE GAS -- PHOSGENE -- MUSTARD GAS -- LEWISITE -- PHOSGENE OXIME -- CYANIDE AND HYDROGEN CYANIDE -- MILITARY NERVE AGENTS -- REFERENCES -- Chapter 7 Regulatory considerations in veterinary toxicology -- INTRODUCTION -- SECTION I. FOOD AND DRUG ADMINISTRATION AND THE CENTER FOR VETERINARY MEDICINE -- SECTION II. ENVIRONMENTAL PROTECTION AGENCY -- SECTION III. US DEPARTMENT OF AGRICULTURE -- SECTION IV. DRUG ENFORCEMENT ADMINISTRATION -- SECTION V. OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION -- SECTION VI. STATUTES, REGULATIONS, AND GUIDELINES -- REFERENCES -- Chapter 8 Toxicology and the law -- INTRODUCTION -- REASONS FOR CONDUCTING TOXICOLOGY ANALYSES -- JURISDICTION - WHAT ARE THE RULES IN THIS FIGHT AND WHO DECIDES THE WINNER? -- STANDARD OF PROOF - HOW SURE DO I NEED TO BE? -- EVIDENCE -- ADMISSIBILITY OF EXPERT TESTIMONY -- SPECIFIC CAUSATION: THE DIFFERENTIAL DIAGNOSIS -- APPLICATION OF DAUBERT IN TOXICOLOGY CASES -- SOME QUESTIONS TO CONSIDER WHEN USING LABORATORY RESULTS IN A LEGAL CASE -- ACKNOWLEDGMENT -- REFERENCES -- FURTHER READING -- Part 2 Organ Toxicity -- Chapter 9 Neurotoxicity -- INTRODUCTION -- STRUCTURAL TOXICOSES -- FUNCTIONAL TOXICOSES -- ION CHANNELS -- CONCLUSION -- REFERENCES -- Chapter 10 Liver toxicity -- INTRODUCTION -- STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE LIVER -- FACTORS INFLUENCING TOXIC LIVER INJURY -- TYPE OF CHEMICALLY MEDIATED LIVER INJURY -- MECHANISMS OF LIVER DAMAGE -- ON THE HORIZON -- REFERENCES -- Chapter 11 Renal toxicity -- INTRODUCTION -- ANATOMY -- BIOTRANSFORMATION AND EXCRETION -- TOXIC EFFECTS ON KIDNEY -- NEPHROTOXIC AGENTS -- DRUGS -- METALS -- PESTICIDES -- MISCELLANEOUS AGENTS -- PLANTS -- CONCLUSION -- REFERENCES -- Chapter 12 Respiratory toxicity -- INTRODUCTION -- LUNG STRUCTURE AND FUNCTION.

GENERAL PRINCIPLES IN THE PATHOGENESIS OF LUNG DAMAGE CAUSED BY CHEMICALS -- ACUTE RESPONSES OF THE LUNG TO INJURY -- CHRONIC RESPONSES OF THE LUNG TO INJURY -- AGENTS KNOWN TO PRODUCE LUNG INJURY IN ANIMALS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 13 Cardiovascular toxicity -- INTRODUCTION -- TOXIC PLANTS AFFECTING THE CARDIAC SYSTEM -- PESTICIDES AND ECONOMIC POISONS AFFECTING THE CARDIAC SYSTEM -- SOLVENTS AFFECTING THE CARDIAC SYSTEM -- DRUGS AFFECTING THE CARDIAC SYSTEM -- REFERENCES -- FURTHER READING -- Chapter 14 Reproductive toxicity and endocrine disruption -- INTRODUCTION -- IMPORTANT DEFINITIONS AND CONCEPTS -- NORMAL ANIMAL REPRODUCTION -- THE MECHANISMS AND EFFECTS OF REPRODUCTIVE TOXICANTS -- CONCLUSIONS -- REFERENCES -- Chapter 15 Placental toxicity -- INTRODUCTION -- ROLE OF THE PLACENTA -- TYPES OF PLACENTA -- METABOLISM IN PLACENTA -- PLACENTAL SUSCEPTIBILITY TO CHEMICAL TOXICANTS -- PLACENTAL BARRIER FOR CHEMICAL TOXICANTS -- FACTORS THAT MAY INFLUENCE THE PLACENTAL TOXICITY -- PLACENTAL TOXICITY OF METALS -- PLACENTAL TOXICITY OF INSECTICIDES -- MYCOTOXINS -- TOBACCO -- CONCLUSIONS AND FUTURE DIRECTIONS -- ACKNOWLEDGEMENTS -- REFERENCES -- Chapter 16 Dermal toxicity -- INTRODUCTION -- ABSORPTION -- PLANTS CAUSING DERMAL TOXICITY IN ANIMALS -- TOPICAL CHEMICALS CAUSING DERMAL TOXICITY IN ANIMALS -- SYSTEMIC COMPOUNDS CAUSING DERMAL TOXICITY IN ANIMALS -- ASSESSMENT METHODS -- REFERENCES -- Chapter 17 Blood and bone marrow toxicity -- INTRODUCTION -- ANATOMY -- HEMATOPOIETIC STEM CELLS -- BLOOD COMPONENTS -- BIOCHEMICAL BASIS OF HEMATOPOIETIC TOXICITY -- TOXICITY-INDUCED ALTERATIONS OF HEMATOPOIETIC ELEMENTS -- PERSPECTIVES -- REFERENCES -- Chapter 18 Immunotoxicity -- INTRODUCTION -- THE IMMUNE SYSTEM -- POSSIBLE MECHANISMS FOR IMMUNOTOXICITY -- IMMUNOTOXIC AGENTS -- TESTING FOR IMMUNOTOXIC POTENTIAL OF CHEMICALS.

FUTURE TRENDS -- REFERENCES -- Part 3 Nanoparticles, Radiation, and Carcinogenesis -- Chapter 19 Biomedical responses and toxicity of nanoparticles -- INTRODUCTION -- BASIC NP CONCEPTS -- ANIMAL OR TISSUE EXPOSURES -- ENVIRONMENTAL EPIDEMIOLOGY -- RISK FROM PRODUCTION OF MANUFACTURED NPS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 20 Oxidative stress and neurodegeneration -- INTRODUCTION -- OXIDATIVE STRESS AND NEURONAL INJURY -- OXIDATIVE STRESSORS: HEAVY METALS, ENVIRONMENTAL TOXICANTS, AND TOBACCO -- ROLES OF OXIDATIVE STRESS, GLUTATHIONE DEPLETION, HSP AND MITOCHONDRIAL DYSFUNCTION IN NEURODEGENERATIVE DISEASES -- PATHOPHYSIOLOGY OF NEURODEGENERATIVE DISEASES -- PROTECTION AGAINST NEURODEGENERATIVE DISEASES: TOCOPHEROL, ASCORBIC ACID, AND OTHER ANTIOXIDANTS -- CONCLUSIONS -- REFERENCES -- Chapter 21 Radiation and radioactive materials -- INTRODUCTION -- BASIC RADIATION CONCEPTS -- INTERACTION OF RADIATION WITH MATTER -- ABSORBED DOSE -- MECHANISMS OF DNA DAMAGE AND MUTAGENESIS -- ANIMAL EXPOSURES AND RADIATION TOXICITY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 22 Carcinogenesis: mechanisms and models -- INTRODUCTION -- TERMINOLOGY -- CANCER EPIDEMIOLOGY -- AGENTS CAUSING CARCINOGENESIS -- CLASSIFICATION OF CARCINOGENS -- ASSAYS FOR CARCINOGENS -- CONCLUSION -- REFERENCES -- Part 4 Drugs of Use and Abuse -- Chapter 23 Toxicity of over-the-counter drugs -- INTRODUCTION -- ANALGESICS -- COLD, COUGH, AND ALLERGY MEDICATIONS -- DRUGS USED TO TREAT GASTROINTESTINAL SYMPTOMS -- TOPICAL DRUGS -- REFERENCES -- Chapter 24 Toxicity of drugs of abuse -- INTRODUCTION -- THE VETERINARIAN AND THE DRUG ENFORCEMENT ADMINISTRATION (DEA) -- STIMULANTS -- HALLUCINOGENS AND DISSOCIATIVE DRUGS -- CONCLUSION -- REFERENCES -- USEFUL WEBSITES -- Part 5 Metals and Micronutrients -- Chapter 25 Aluminum -- INTRODUCTION -- BACKGROUND -- TOXICOKINETICS.

MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 26 Arsenic -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUSION -- REFERENCES -- Chapter 27 Cadmium -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUDING REMARKS/FUTURE DIRECTIONS -- REFERENCES -- Chapter 28 Copper -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUSION -- REFERENCES -- Chapter 29 Fluoride -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS AND MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- REFERENCES -- Chapter 30 Iron -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUDING REMARKS -- REFERENCES -- Chapter 31 Lead -- INTRODUCTION -- BACKGROUND -- TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUDING REMARKS -- REFERENCES -- Chapter 32 Mercury -- INTRODUCTION -- BACKGROUND -- TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 33 Molybdenum -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUDING REMARKS AND/OR FUTURE DIRECTION -- REFERENCES -- Chapter 34 Selenium -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/TOXICOKINETICS -- MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUDING REMARKS AND FUTURE DIRECTIONS -- REFERENCES -- Chapter 35 Sodium chloride (salt) -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/MECHANISM OF ACTION -- TOXICITY -- TREATMENT -- CONCLUDING REMARKS -- REFERENCES -- Chapter 36 Sulfur -- INTRODUCTION -- BACKGROUND -- PHARMACOKINETICS/TOXICOKINETICS -- MECHANISM OF ACTION.

TOXICITY.