Cover -- Handbook of Pediatric Transfusion Medicine -- Copyright -- Dedication -- Table of Contents -- Preface -- Acknowledgments -- About the Editors -- List of Contributors -- Chapter 1 Blood Donation -- Overview -- Donor Recruitment -- Autologous Donation -- Directed Donation -- Limited Donor Exposure -- Blood Collection -- Apheresis -- Plasmapheresis -- References -- Chapter 2 Component Preparation and Storage -- Introduction -- Unique Transfusion Needs of the Neonatal and Pediatric Patient -- Blood Donation Issues -- Anticoagulant-Preservative Solutions -- Individual Components for Transfusion -- Record Keeping for Component Preparation -- Storage of Blood and Blood Products -- Summary -- References -- Chapter 3 Blood Components -- Introduction -- Whole Blood and Packed Red Blood Cells -- Platelets -- Granulocytes -- Plasma Products -- Cryoprecipitate -- Ordering -- Coagulation Factors -- Albumin -- Gamma-Globulins -- References -- Chapter 4 Red Blood Cell Antigens and Human Blood Groups -- Introduction -- ABO Blood Group System -- RH Blood Group System -- Kell Blood Group System -- Duffy Blood Group System -- Clinical Significance -- Kidd Blood Group System -- MNS Blood Group System -- P Blood Group System -- Lutheran Blood Group System -- Lewis Blood Group System -- Diego Blood Group System -- Cartwright Blood Group System -- Xg Blood Group System -- Scianna Blood Group System -- Dombrock Blood Group System -- Colton Blood Group -- LW Blood Group System -- Chido-Rogers Blood Group System -- Hh Blood Group System -- XK Blood Group System -- Gerbich Blood Group System -- Cromer Blood Group System -- Knops Blood Group System -- Indian Blood Group System -- Ok Blood Group System -- RAPH Blood Group System -- JMH Blood Group System -- Cost Blood Group Collection -- Er Blood Group Collection -- Ii Blood Group Collection -- Globoside Collection.

Low-Prevalence Antigens -- High-Prevalence Antigens -- References -- Chapter 5 Pretransfusion Compatibility Testing -- Introduction -- ABO(H) -- Rh(D) -- Other Red Cell Antigens -- Direct Antiglobulin Test -- Antibody Detection Test (Screen) -- Crossmatch (XM) -- Turnaround Times -- Suggested Reading -- References -- Chapter 6 Serologic Investigation of Unexpected Antibodies -- Introduction -- Common Antibody Identification Methods -- Process for Evaluation of Positive Antibody Detection Tests -- References -- Chapter 7 Leukoreduced Products: Prevention of Leukocyte-Related Transfusion-Associated Adverse Effects -- Introduction -- Rationale for Leukoreduction of Blood Components -- Specific Indications for LR Products -- Contraindications, Side Effects, and Hazards -- Leukoreduction Technologies -- Products, Standards, and Quality Control -- Universal Leukoreduction -- Leukoreduced Blood Products and Pediatric Transfusion Medicine -- References -- Chapter 8 Preparation of Blood Components to Reduce Cytomegalovirus and Other Infectious Risks -- Introduction -- Red Blood Cell and Platelet Components with Reduced Infectious Risks -- Plasma Components, Derivatives, and Factors to Eliminate Pathogens -- Nucleic Acid Targeted Inactivation Strategies -- Summary -- References -- Chapter 9 Irradiated Products -- History -- Pathogenesis -- Clinical Manifestations -- Diagnosis of TA-GVHD -- Time Course of Microchimerism -- Groups at Risk -- The Irradiation Process -- Instrumentation for Irradiation -- Components to be Irradiated -- Storage of Red Cells and Platelets after Irradiation -- Selection of Radiation Dose -- Quality Assurance Measures -- Confrming That Irradiation Occurred -- New Methods in the Prevention of TA-GVHD -- Treatment of TA-GVHD -- References.

Chapter 10 Washed and/or Volume- Reduced Blood Components -- Introduction -- Washed Red Blood Cells -- Washed And Volume-Reduced Platelet Concentrates -- References -- Chapter 11 Technical Considerations/Mechanical Devices -- Introduction -- Intravenous Delivery Systems for Blood and Components -- Exchange Transfusion in the Newborn -- References -- Chapter 12 Red Blood Cell Transfusions in the Neonate, Infant, Child, and Adolescent -- Introduction -- RBC Transfusions for Children and Adolescents -- RBC Transfusions for Neonates and Infants -- References -- Chapter 13 Transfusion of the Pediatric Surgery, Trauma, and Intensive Care Unit Patient -- Abstract -- Age, Size, and Rate of Transfusion -- Red Blood Cell Transfusion -- Platelet Transfusions -- Cryoprecipitate and Fresh Frozen Plasma -- Hemostatic Agents in Acute Care -- References -- Chapter 14 Pediatric Transfusion in Developing Countries -- Introduction -- Special Transfusion Issues in Resource-Restricted Countries -- Blood Collection and Processing in Developing Countries -- Risks of Infectious Disease Transmission by Transfusion -- Current Transfusion Practices -- Prevention Measures to Reduce Need for Transfusion -- References -- Chapter 15 Exchange Transfusion in the Infant -- Introduction -- Rationale and Indications -- Procedure -- Selection of Donor Blood -- Complications -- References -- Chapter 16 Granulocyte Transfusions in the Neonate and Child -- Abstract -- Introduction -- Myelopoiesis -- Neonatal Neutropenia and Dysfunction -- Childhood Neutropenia -- Mobilization of Donor Granulocytes -- Therapeutic Granulocyte Transfusions in Children and Adults -- Granulocyte Transfusion in the Neonate -- Summary and Recommendations of Granulocyte Transfusions -- References.

Chapter 17 Extracorporeal Membrane Oxygenation and Cardiopulmonary Bypass -- Introduction -- Circuit for ECMO and CPB -- ECMO -- CPB -- Summary -- References -- Chapter 18 Hemolytic Disease of the Newborn -- Introduction -- Immune-Mediated Hemolytic Disease -- Rh Hemolytic Disease -- ABO Hemolytic Disease -- Hemolytic Disease Due to Other Red Cell Antibodies -- T Activation -- Autoimmune Hemolytic Disease -- Red Cell Enzyme Deficiencies -- Red Cell Membrane Defects -- Disorders of Hemoglobin Synthesis -- Other Causes of Hemolytic Disease in Neonates -- Therapy -- References -- Chapter 19 Hemoglobinopathies -- Introduction -- Sickle Cell Disease -- Thalassemias -- References -- Chapter 20 The Bleeding Child: Congenital and Acquired Disorders -- Abstract -- Introduction -- Coagulation Overview -- Clinical Evaluation of Bleeding Problems -- Laboratory Evaluation -- Specific Factor Assays -- Inherited Coagulation Disorders -- Acquired Hemorrhagic Disorders -- References -- Chapter 21 Transfusion of the Patient with Autoimmune Hemolysis -- Introduction -- Clinical Presentation and Laboratory Findings -- Classification -- Warm Autoimmune Hemolytic Anemia -- Cold Agglutinin Syndrome -- Mixed-Type Autoimmune Hemolytic Anemia -- Drug-Induced Hemolytic Anemia -- Less Common Types of Autoimmune Hemolytic Anemia -- Transfusion Therapy in Autoimmune Hemolytic Anemia -- References -- Chapter 22 Platelet Transfusions in the Infant and Child -- Introduction -- Platelet Products and Special Preparations -- Platelet Transfusions in Children -- Platelet Transfusions in Neonates -- Reactions to Platelet Transfusions -- Potential Alternatives to Platelet Transfusions -- References -- Chapter 23 Bone Marrow-Derived Stem Cells -- Introduction -- Product Description -- Collection and Storage -- Special Preparation and Processing -- Expected Response.

Alternative HPC Sources -- References -- Chapter 24 Peripheral Blood Stem Cells -- Introduction -- Product Description -- Collection -- Special Preparation -- Ordering and Administration -- Potential Adverse Effects -- Alternative HPC Sources -- References -- Chapter 25 Umbilical Cord Blood Stem Cells -- Introduction -- Collection, Storage, and Handling -- Clinical Applications -- References -- Chapter 26 Transfusion Reactions -- Introduction -- Acute Hemolytic Transfusion Reactions -- Febrile Nonhemolytic Transfusion Reactions -- Allergic Transfusion Reactions -- Delayed Hemolytic Transfusion Reactions -- Special Considerations for Newborn Infants -- References -- Chapter 27 Noninfectious Complications of Pediatric Transfusion -- Introduction -- Transfusion Reactions -- Metabolic Complications -- Cardiac Overload -- Alloimmunization -- T Antigen Activation -- Dilutional Coagulopathy -- Complications of Iron Overload from Chronic Transfusion -- References -- Chapter 28 Infectious Complications -- Introduction -- Human Immunodeficiency Virus -- Hepatitis -- Human T-Cell Lymphotropic Virus (HTLV) -- Cytomegalovirus -- Parvovirus B19 -- Parasitic Infections -- Creutzfeldt-Jakob Disease -- Bacterial Infections -- References -- Chapter 29 Therapeutic Apheresis -- Introduction -- Goals of Therapeutic Apheresis -- Indication Categories -- Physiology and Adverse Effects -- General Approach to Pediatric Patients Needing Therapeutic Apheresis -- Planning Pediatric Procedures -- Vascular Access -- Hemodynamic Challenges -- Procedural Modifications for Pediatric Patients -- Summary -- Suggested Reading -- Chapter 30 Therapeutic Cytapheresis -- Introduction -- Evidence-Based Practice Guidelines -- General Technical Considerations for Pediatrics -- Erythrocytapheresis/Red Cell Exchange Transfusion -- Leukapheresis -- Plateletpheresis (Thrombocytapheresis).

Adverse Reactions.