Front Cover -- Biomedical Information Technology -- Copyright Page -- Contents -- Acknowledgments -- About the Editor -- Contributors -- Introduction -- Section I: Technological Fundamentals -- Chapter 1: Medical Imaging -- 1.1 Introduction -- 1.7 Diffuse Optical Imaging -- 1.10 Exercises -- 1.11 References and Bibliography -- Chapter 2: Electronic Medical Records -- 2.1 Introduction -- 2.2 Medical Data and Patient Records -- 2.4 Information Exchange Standards -- 2.5 Usability Issues in Electronic Medical Records -- 2.6 User Interface -- 2.7 Evaluation -- 2.8 Electronic Medical Records System-A Case Study: AWeb-Based Electronic Record for Medical Imaging -- 2.9 Summary -- Acknowledgements -- 2.10 Exercises -- 2.11 References and Bibliography -- Chapter 3: Image Data Compression and Storage -- 3.1 Introduction -- 3.2 Picture Compression -- 3.3 Compression in the DICOM Standard -- 3.4 Data Compression for Dynamic Functional Images -- 3.5 Summary -- Acknowledgements -- 3.6 Exercises -- 3.7 References and Bibliography -- Chapter 4: Content-Based Medical Image Retrieval -- 4.1 Introduction -- 4.2 Content-Based Medical Image Retrieval by Physical Visual Features -- 4.3 Content-Based Medical Image Retrieval by Geometric Spatial Filters -- 4.4 Content-Based Medical Image Retrieval by Combination of Semantic and Visual Features -- 4.5 Content-Based Medical Image Retrieval by Physiologically Functional Features -- 4.6 Summary -- Acknowledgments -- 4.7 Exercises -- 4.8 References and Bibliography -- Chapter 5: Data Modeling and Simulation -- 5.1 Introduction -- 5.2 Compartment Models -- 5.4 Model Validation -- 5.5 Simulation -- 5.6 Case Study -- 5.8 Exercises -- 5.9 References and Bibliography -- Chapter 6: Techniques for Parametric Imaging -- 6.1 Introduction -- 6.3 Noninvasive Methods -- 6.5 Summary -- Acknowledgments -- 6.6 Exercises.

6.7 References and Bibliography -- Chapter 7: Data Processing and Analysis -- 7.1 Introduction -- 7.2 Medical Image Enhancement -- 7.3 Medical Image Segmentation -- 7.4 Medical Image Feature Extraction -- 7.5 Medical Image Interpretation -- 7.6 Summary -- 7.7 Exercises -- 7.8 References and Bibliography -- Chapter 8: Data Registration and Fusion -- 8.1 Introduction -- 8.3 Feature-Based Medical Image Registration -- 8.4 Intensity-Based Registration -- 8.5 Hybrid Registration and Hierarchical Registration -- 8.6 Hardware Registration -- 8.7 Assessment of Registration Accuracy -- 8.8 Applications of Biomedical Image Registration and Fusion -- 8.9 Summary -- Acknowledgments -- 8.10 Exercises -- 8.11 References and Bibliography -- Chapter 9: Data Visualization and Display -- 9.1 Introduction -- 9.4 Volume Navigation Interface -- 9.7 Dual-Modality Positron Emission Tomography-Computed Tomography Visualization -- 9.8 Data Display Devices -- 9.9 Applications of Biomedical Visualization -- 9.10 Summary -- Acknowledgments -- 9.11 Exercises -- 9.12 References and Bibliography -- Chapter 10: Data Communication and Network Infrastructure -- 10.1 Introduction -- 10.2 Transmission and Communication Technologies -- 10.3 The Internet and World Wide Web -- 10.5 Sensor Networks for Health Monitoring -- 10.7 Summary -- 10.8 Exercises -- 10.9 References and Bibliography -- Chapter 11: Data Security and Protection for Medical Images -- 11.1 Introduction -- 11.2 Overview of Cryptographic System -- 11.3 Digital Watermarking -- 11.4 Medical Image Watermarking -- 11.6 Summary -- Acknowledgments -- 11.7 Exercises -- 11.8 References and Bibliography -- Chapter 12: Biologic Computing -- 12.1 Introduction -- 12.2 Overview of Genomic Methods -- 12.3 Overview of Proteomic Methods -- 12.5 Data Mining and Large-Scale Biologic Databases.

12.6 Biologic Event-Driven, Time-Driven and Hybrid Simulation Techniques -- Section II: Integrated Applications -- Chapter 13: PACS and Medical Imaging Informatics for Filmless Hospitals -- 13.1 Introduction -- 13.2 PACS Infrastructure -- 13.5 Large-Scale PACS Implementation -- 13.6 PACS Clinical Experiences -- 13.8 Exercises -- 13.9 References and Bibliography -- Chapter 14: KMeX: A Knowledge-Based Digital Library for Retrieving Scenario-Specific Medical Text Documents -- 14.1 Introduction -- 14.2 Extracting Key Concepts From Documents -- 14.3 Transforming Similar Queries into Query Templates -- 14.4 Topic-Oriented Directory -- 14.5 Phrase-Based Vector Space Model for Automatic Document Retrieval -- 14.6 Knowledge-Based Scenario-Specific Query Expansion -- Acknowledgments -- 14.9 Exercises -- 14.10 References and Bibliography -- Chapter 15: Integrated Multimedia Patient Record Systems -- 15.1 Introduction -- 15.2 Multimedia Patient Record -- 15.3 Components of the Multimedia Patient Record System Architecture -- 15.4 Electronic Medical Chart Components -- 15.5 Objects Comprising the Multimedia Patient Record -- 15.6 Capturing Multimedia Data with a Clinical Workstation -- 15.7 DICOM Image Acquisition -- 15.8 Remote Data and Image Viewing Across the Health Care Network -- 15.9 Impact on Patient Care -- 15.10 Summary -- 15.11 References and Bibliography -- Chapter 16: Computer-Aided Diagnosis -- 16.1 Introduction -- 16.2 Computer-Aided Diagnosis -- 16.4 Computer-Aided Diagnosis for Differential Diagnosis -- 16.3 Computer-Aided Diagnosis for Cancer Screening -- 16.5 Intelligent Computer-Aided Diagnosis Workstations: Indices of Similarity and Human/Computer Interfaces -- Acknowledgments -- 16.6 Summary -- 16.7 Exercises -- 16.8 References and Bibliography -- Chapter 17: Clinical Decision Support Systems -- 17.1 Introduction.

17.4 A Structure for Characterizing Clinical Decision Support Systems -- 17.5 Decision Support Tools -- 17.6 Decision Support Systems in the Hospital and Other Health Care Settings -- 17.7 Health Care Education Applications -- 17.10 Exercises -- 17.11 References and Bibliography -- Chapter 18: Medical Robotics and Computer-Integrated Interventional Medicine -- 18.1 Introduction -- 18.4 Surgical Assistance -- 18.7 References and Bibliography -- Chapter 19: Functional Techniques for Brain Magnetic Resonance Imaging -- 19.1 Introduction -- 19.2 Diffusion-Weighted Magnetic Resonance Imaging in Brain -- 19.3 Magnetic Resonance Perfusion Imaging in Brain -- 19.4 Functional Magnetic Resonance Imaging Using BOLD Techniques -- 19.5 Clinical Magnetic Resonance Spectroscopy in Brain -- 19.6 Summary -- Acknowledgments -- 19.7 Exercises -- 19.8 References and Bibliography -- Chapter 20: Molecular Imaging in Cancer -- 20.1 Introduction -- 20.3 Receptor Imaging -- 20.7 Imaging of the Tumor Microenvironment -- 20.8 Multimodality Imaging -- 20.11 References and Bibliography -- Chapter 21: Molecular Imaging in Biology and Pharmacology -- 21.1 Introduction and Background -- 21.2 Considerations for Quantitative Molecular Imaging -- 21.3 Design/Development of Molecular Imaging Probes -- 21.4 Molecular Imaging of Beta-Amyloid and Neurofibrillary Tangles -- 21.5 Molecular Imaging Using Antibody Probes -- 21.6 Some Other Molecular Imaging Applications -- 21.7 Summary and Future Perspectives -- 21.8 Exercises -- 21.9 References and Bibliography -- Chapter 22: From Telemedicine to Ubiquitous M-Health: The Evolution of E-Health Systems -- 22.1 Introduction -- 22.2 Overview of M-Health Systems -- 22.3 M-Health Based on Wireless Body Area Networks -- 22.5 Wireless Mobile Devices for M-Health -- 22.6 Next-Generation M-Health Systems -- 22.7 Summary -- 22.8 Exercises.

22.9 References and Bibliography -- Chapter 23: Multimedia for Future Health-Smart Medical Home -- 23.1 Introduction -- 23.2 Multimedia for Human-Computer Interaction -- 23.3 Multimedia Content Management -- 23.4 Multimedia Delivery -- 23.5 Smart Medical Home -- 23.6 Telemedicine in the Smart Medical Home -- 23.7 Sensory Devices and Health Monitoring -- 23.8 Speech Recognition and Conversational Systems -- 23.9 Multimedia Technologies for Patient Education and Care -- 23.10 Multimedia Operating Theater and Virtual Reality -- 23.11 Summary -- Acknowledgments -- 23.12 Exercises -- 23.13 References and Bibliography -- Index.