Contents -- Dedication -- Foreword by Prof W. R. Green -- Foreword by Prof R. B. Nussenblatt -- Preface -- Chapter 1 Definition of Primary Intraocular Lymphoma -- References -- Chapter 2 History of Primary Intraocular Lymphoma (1950s-1970s) -- References -- Chapter 3 Classification of Lymphomas -- References -- Chapter 4 Epidemiology of Primary Intraocular Lymphoma -- Incidence and Prevalence Within the Immunocompetent Population -- Demographics Within the Immunocompetent Population -- Prevalence and Incidence Within the AIDS Population -- Demographics Within the AIDS Population -- PCNSL and PIOL in Other Immunocompromised Populations -- Understanding the Rise in Incidence of PCNSL -- References -- Chapter 5 Clinical Manifestations of PIOL -- Historical Account -- Modern Clinical Manifestations -- Systemic Presentations and Manifestations -- CNS and Ocular Symptoms, and Manifestations -- Ocular Examinations -- Summary of Clinical Manifestations and Findings -- Differential Diagnoses -- References -- Chapter 6 Imaging -- Full Field Fundus Photography -- Ultrasound -- Fluorescein Angiography -- Indocyanine Green Fluorescein Angiography -- Ocular Coherence Tomography -- Brain Imaging -- Systemic Imaging -- References -- Chapter 7 Pathology -- Cytology -- Ocular Pathology -- Brain Pathology -- Molecular Pathology -- References -- Chapter 8 Immunology of PIOL -- The Role of T-cells in PIOL -- The Role of Macrophages in PIOL -- The Role of the Dendritic Cell in PIOL -- Cytokines and Chemokines -- References -- Chapter 9 Diagnostic Approaches -- Historical Diagnostic Approaches -- Modern Diagnostic Approaches -- References -- Chapter 10 Management and Treatment of PIOL -- Historical Therapies -- Contemporary Treatment of PIOL -- References -- Chapter 11 Prognosis in PIOL -- Historical Attempts at Prognostication -- Modern Prognosis -- References.

Chapter 12 Hypotheses on the Origin of PIOL -- Homing of Lymphoma Cells to the CNS and the Eye -- Derivation of Lymphoma Cells -- Multicentricity of PCNSL/PIOL -- Origin of PCNSL/PIOL in Immunocompromised Patients -- Annotation -- References -- Chapter 13 Experimental Models of PIOL -- Historical Experimental PCNSL Models in Animals -- Recent Murine Models of PIOL/PCNSL -- References -- Chapter 14 Summary and Algorithm -- References -- Chapter 15 The Future of PIOL -- References -- Chapter 16 Case Illustrations -- Case 1 -- Case 2 -- Case 3 -- Case 4 -- Case 5 -- Case 6 -- References -- Author Index -- Subject Index.