CONTENTS -- Acknowledgements -- Introduction Innovation in Health Care: The Engine of Technological Advances R. A. Atun and D. Sheridan -- References -- Innovation Models in the Biopharmaceutical Sector J. Attridge -- General Models of Innovation -- Appropriating the Value of Innovation -- Diffusion and Adoption of Innovations -- Distinguishing Features of the Biopharmaceutical Sector and Its Environment -- Partial Innovation Models in the Biopharmaceutical Sector -- Systems and boundaries -- Classification models -- Business, Portfolio and Product Lifecycle Models -- Business models and corporate strategy -- R&D investment and portfolio models -- Individual product strategy and life cycle models -- The "big pharma" - SME - academia interface -- Innovation networks and clusters in biopharmaceuticals -- Diffusion and Adoption of Medicines -- Demand side decision making -- International comparisons of diffusion rates -- Diffusion models and health technology assessment -- Appropriability and sustainability in biopharmaceuticals -- The Post-2000 Pharmaceutical Innovation Model -- Conclusions -- References -- Development and Innovation in Cardiovascular Medicine D. Sheridan -- Introduction -- Early Developments -- Cardiovascular Imaging -- Ultrasound imaging -- X-ray imaging -- Development and Innovation in Cardiovascular Therapies -- β-blockers -- Calcium antagonists -- ACE inhibitors -- Antithrombotic therapy -- Lipid lowering drugs -- Conclusions -- References -- Development and Innovation in Cancer Medicine K. Sikora -- Introduction -- The past -- The future -- Prevention and Screening -- Detecting Cancer -- New Treatment Approaches -- Barriers to Innovation -- Patient's Experience -- Professional Recon.guration -- Conclusion -- References -- Innovation, Patents and Economic Growth R. A. Atun, I. Harvey and J. Wild -- Introduction.

Patents and Intellectual Property -- Innovation, IP and Competitiveness: The Evidence and Arguments -- Country level studies -- Industry orfirm-level studies -- Country Case Studies -- The United States -- Japan -- China -- The European Union -- Company Case Studies -- IBM -- Cambridge Display Technology Limited -- Dow -- Novo Nordisk -- Conclusions -- References -- Uptake and Diffusion of Pharmaceutical Innovations in Health Systems R. A. Atun, I. Gurol-Urganci and D. Sheridan -- Introduction -- Innovation Models -- Health Systems Goals and Objectives -- How Regulation In.uences Uptake and Diffusion of Innovations in Health Systems -- The Regulatory Environment -- Price regulation -- Direct price controls -- Profit controls -- Reference pricing -- Cross-country price differentials and parallel trade -- Generic entry and price competition -- Health technology assessment -- Changes in Health System Financing -- Effect of health insurance -- Cost sharing -- Drug budgets and prescribing limits -- Organisational Changes -- General practice fundholding in the UK -- Managed care in the US -- Service Provision -- Disease management -- Formularies -- Discussions and Conclusions -- References -- Partnership and Innovation in the Life Sciences D. Kleyn, R. Kitney and R. A. Atun -- Introduction -- Methodology -- Results -- General partnering activities -- Varied partnerships -- Critical success factors for effective partnering -- Organisational structure -- Operational management -- Leadership -- Developing organisational capabilities to improve partnering -- Creating an enabling environment for partnering -- Is R&D partnering working? -- Should We Continue to Invest in this Area? -- Conclusions -- References -- Innovation and Partnering in R&D -- Partnering strategies to increase innovation in R&D -- Methods for decision-making -- Managing projects.

Organising for success -- Growing role of university partnerships -- Index.