Cover image for Cardiac Arrest : The Science and Practice of Resuscitation Medicine.
Cardiac Arrest : The Science and Practice of Resuscitation Medicine.
Title:
Cardiac Arrest : The Science and Practice of Resuscitation Medicine.
Author:
Paradis, Norman A.
ISBN:
9780511354311
Personal Author:
Edition:
2nd ed.
Physical Description:
1 online resource (1374 pages)
Contents:
Cover -- Half-title -- Title -- Copyright -- Dedication -- Contents -- Contributors -- Preface to the first edition -- Foreword -- Preface to the first edition -- Preface to the second edition -- Part I Introduction -- 1 A history of cardiopulmonary resuscitation -- The earliest years -- The search for artificial ventilation -- The kiss of life -- The search for artificial circulation -- The birth of cardiopulmonary resuscitation -- Ventilation and compression combined -- From electrical therapy to defibrillation -- Prehospital resuscitation -- Paramedic-staffed mobile intensive care units -- The quest continues -- REFERENCES -- 2 The epidemiology of sudden death -- Epidemiology and the study of cardiac arrest -- Definition of sudden death -- Global burden of illness -- Incidence vs. survival -- Data sources -- Accuracy of data -- Incidence of cardiac arrest -- Unexpected cardiac death in children -- Unexpected cardiac death in hospital -- High-risk subgroups -- Calculating incidence of cardiac arrest -- Risk factors for incidence of cardiac arrest -- Cellular -- Environment -- Social -- Behavioral -- Clinical -- Health system -- Variation in process and outcome after unexpected cardiac death -- Risk factors affecting survival from sudden death -- Social -- Location -- Witnessed cardiac arrest -- Clinical -- Initial cardiac rhythm -- Age -- Gender -- Race -- Health system -- Bystander cardiopulmonary resuscitation -- Lay responder defibrillation -- Paramedic-witnessed cardiac arrest -- Short treatment intervals -- Rescuer performance -- Future directions -- REFERENCES -- Part II Basic science -- 3 Global cellular ischemia/reperfusion during cardiac arrest: critical stress responses and the postresuscitation syndrome -- The post-resuscitation syndrome -- Redox-mediated intracellular stress responses -- The oxidant tipping point.

Circulating messengers of I/R injury: extracellular oxidants and cytokines/chemokines -- Transcriptional pathways of critical stress response -- Post-resuscitation syndrome: the connection among oxidant stress, inflammation, and apoptosis -- Programmed cell death in the heart -- Necrosis/oncosis -- Paraptosis and pyroptosis - caspase-associated non-apoptotic cell death -- Autophagy -- Apoptosis -- Caspases -- Pathways of caspase activation -- The Bcl-2 family -- AIF and EndoG - caspase-independent apoptosis? -- Apoptosis as an anti-inflammatory strategy -- Conclusion -- REFERENCES -- 4 Genetics, genomics and proteomics in sudden cardiac death -- Introduction -- Genetics of cardiac ion channel diseases causing sudden death -- Introduction -- Strategies for genetic analysis -- Long QT syndrome -- Clinical presentation -- Genetic bases and pathophysiology -- Genotype-phenotype correlation -- Brugada syndrome -- Clinical presentation -- Genetic basis and pathophysiology -- Progressive cardiac conduction defect -- Clinical presentation -- Genetic defects and pathophysiology -- Sick sinus syndrome -- Clinical presentation -- Genetic defects and pathophysiology -- Familial atrial fibrillation -- Clinical presentation -- Genetic bases and pathophysiology -- Short QT syndrome -- Clinical presentation -- Genetic bases and pathophysiology -- Catecholaminergic polymorphic ventricular tachycardia -- Clinical presentation -- Genetic bases and pathophysiology -- Conclusions -- Genomics and sudden cardiac death -- Introduction -- The limitation of linkage studies -- Association studies -- Association studies: in theory -- Association studies: past and present -- Association studies: extending the search -- Assessment of genomic structure -- Conclusions -- Proteomics and sudden cardiac death -- Overview of proteomics strategies.

Searching for answers to sudden cardiac death using proteomics -- Heart tissue -- Serum -- Future prospects -- Conclusions -- Acknowledgments -- REFERENCES -- Genetics -- 5 Intracellular signaling during myocardial ischemia -- Introduction -- The stress-activated protein kinases (SAPKs) -- Classification of SAPKs -- SAPK1 -- SAPK2, SAPK3, and SAPK4 -- SAPK5 -- Effects of ischemia and ischemia-reperfusion on SAPK activities -- What are the mediators of ischemia-reperfusioninduced activation of SAPKs? -- How might SAPKs induce myocardial death? -- Activation of additional signaling pathways by ischemia-reperfusion -- Protein kinase Cdelta (PKCdelta) -- The endoplasmic reticulum (ER) stress response SAPK -- Ischemic conditioning -- Potential for therapeutic intervention in ischemia-reperfusion injury -- Conclusions -- REFERENCES -- 6 Electrophysiology of ventricular fibrillation and defibrillation -- Introduction -- Basic science -- Electrophysiology of ventricular fibrillation -- Structural heart disease and sudden death -- Myocardial substrates for ventricular fibrillation -- Ventricular fibrillation in myocardial ischemia -- Ventricular fibrillation in cardiomyopathy -- Ventricular fibrillation in normal hearts -- Primary electrical diseases of the heart -- Therapy of ventricular fibrillation -- Prevention of ventricular fibrillation -- Defibrillation -- Conclusions and future directions -- REFERENCES -- 7 The neuroendocrine response to global ischemia and reperfusion* -- The neuroendocrine system -- Operational definitions (by Jacobo Wortsman, M.D.) -- Methodologic issues in studies of the neuroendocrine response to cardiac arrest (by Jacobo Wortsman, M.D.) -- Neuroendocrine response in the immediate cardiac arrest period -- Pituitary gland -- Anterior lobe -- Pro-opiomelanocortin complex -- ACTH -- beta-Endorphins.

Melanocyte stimulating hormones (MSH) -- Prolactin -- Growth hormone (GH) -- Neurohypophysis (posterior lobe) -- Vasopressin -- Thyroid gland -- Thyroid hormones -- Calcitonin -- Parathyroid glands -- Adrenal glands -- Adrenal medulla -- Catecholamines -- Adrenal cortex -- Cortisol -- Renin-angiotensin-aldosterone system -- Unconventional endocrine organs -- Endothelium -- Heart -- Kidney -- Renin -- Erythropoietin -- Gastrointestinal tract -- Insulin -- Intestinal hormones -- Neuroendocrine response in the postcardiac arrest period -- The distinct neuroendocrine response patterns in acute and prolonged critical illness -- Pituitary gland (anterior lobe) -- ACTH -- beta-Endorphins -- Melanocyte stimulating hormones -- Prolactin -- Growth hormone -- Gonadotropins -- Neurohypophysis (posterior lobe) -- Vasopressin -- Leptin -- Thyroid gland -- Thyroid hormones -- Calcitonin -- Parathyroid glands -- Adrenal glands -- Catecholamines -- Cortisol -- Renin-angiotensin-aldosterone system -- Gonads -- Testes -- Ovaries -- Non-conventional endocrine organs -- Endothelium -- Heart -- Kidney -- Renin -- Erythropoietin -- Gastrointestinal tract -- Insulin -- Intestinal hormones -- Summary -- REFERENCES -- 8 Inflammatory and immunologic responses to ischemia and reperfusion -- Introduction -- Systemic inflammatory response -- Cytokines and reperfusion injury -- Proinflammatory and anti-inflammatory cytokine cascade -- Tumor necrosis factor-alpha -- Interleukin-1 -- Other inflammatory cytokines -- Role of cytokines in the development of postischemic organ injury -- The immune system and reperfusion injury -- Polymorphonuclear leukocytes and postischemic cellular dysfunction -- Regulation of molecular determinants of leukocyte adherence -- Endothelial activation -- Leukocyte adhesion -- Coordination of leukocyte adhesion and extravasation.

Mechanisms of neutrophil-mediated tissue injury -- Mechanisms of macrophage-mediated tissue injury -- Therapeutic implications and future research -- Resuscitation, postresuscitation, hemodynamic decompensation, multiple organ dysfunction, and survival -- Conclusions -- REFERENCES -- Resuscitation research -- 9 Methodology of laboratory resuscitation research -- Basics of theory of measurements -- Definition of measurement and units of measurement -- True value, errors of measurement and accuracy -- Characteristics of measurement instruments and errors of measurement -- Static characteristics and static errors of measurement -- Dynamic characteristics -- Random errors -- Accuracy, precision, bias, and uncertainty -- Static calibration -- Dynamic calibration -- Thoracic compression -- Sternal compression force measurement -- Direction of compression force -- Frequency characteristic of compression force -- Compression force-time course -- Class I: Semisinusoidal course -- Class II:Time course with plateau -- Devices for measuring chest compression force -- Calibration of force measurement devices -- Deformation measurement -- Intrathoracic pressure The use of motion tagging allows the creation of 4D -- MRI -- Blood pressure measurement -- Methods of measuring blood pressure -- Choice of pressure transducers for CPR studies -- Accuracy of blood pressure measurement -- Blood flow measurement in cardiopulmonary resuscitation -- Methods of measuring blood flow -- Distinctive features of blood flow measurement -- Measurement of blood flow with microspheres -- Practical considerations -- Non-radioactive microspheres -- Color -- Neutron-activated -- Blood flow measurement with flow meters -- Electromagnetic flow meters -- Transit-time ultrasonic flow meters -- Ultrasound Doppler flow meters -- Laser Doppler flow meters -- MRI.

Application of flow meters in CPR research.
Abstract:
The definitive and most comprehensive reference volume in advanced life support and resuscitation medicine.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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