
Subthalamic Nucleus Part II : Modelling and Simulation of Activity.
Title:
Subthalamic Nucleus Part II : Modelling and Simulation of Activity.
Author:
Heida, Tjitske.
ISBN:
9783540794622
Personal Author:
Physical Description:
1 online resource (101 pages)
Series:
Advances in Anatomy, Embryology and Cell Biology, 199 ; v.v. 199
Advances in Anatomy, Embryology and Cell Biology, 199
Contents:
CONTENTS -- 1 Introduction -- 2 The Basal Ganglia -- 2.1 Pathways Within the Basal Ganglia -- 2.2 Parkinson's Disease -- 2.3 Deep Brain Stimulation -- 3 STN Activity Recorded in Vitro: Brain Slices -- 3.1 Spontaneous Activity -- 3.2 Depolarizing and Hyperpolarizing Inputs -- 3.3 Ionic Mechanisms of a Plateau Potential -- 3.4 Synaptic Inputs -- 3.5 High-Frequency Stimulation of STN Cells -- 3.6 Intrinsic Versus Extrinsic Properties: Bursts -- 4 STN Activity Recorded in Vitro: Dissociated Cell Cultures -- 4.1 Experimental Set-up -- 4.2 Spontaneous Activity -- 4.3 Addition of Acetylcholine -- 4.4 Electrical Stimulation -- 5 STN Cell Models and Simulation of Neuronal Networks -- 5.1 Otsuka's Model -- 5.2 Terman and Rubin's Model -- 5.3 Comparison of the Otsuka Model with the Terman/Rubin Model -- 5.4 The Multi-compartment STN Model of Gillies and Willshaw -- 5.5 Intra-nuclear Network Models -- 5.6 Inter-nuclear Network Models -- 6 Comparison of Part I and Part II -- 6.1 Recurrent STN Axons -- 6.2 Inter-neurons in the STN -- 6.3 Fibre Tracts around and in the STN -- 6.4 Ca 2+ Receptors -- 6.5 Three-Dimensional Modelling -- 6.6 Types of Projection Neurons -- 6.7 Neurotransmitter Input Versus Receptors in the STN -- 6.8 The Pedunculopontine Nucleus -- 6.9 Nigro-subthalamic Connections -- 6.10 Another Cortico-subthalamic Loop -- 6.11 Nissl-Based Subdivision of the STN -- Appendix 1 Model Parameter Values Otsuka et al. 2004 -- Appendix 2 Model Parameter Values Terman et al. 2002 -- Rubin and Terman (2004) -- References -- Index.
Abstract:
Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinsona (TM)s disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stimulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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