CONTENTS -- 1. BASIC CONCEPTS AND GLOSSARY OF COMMON CLINICAL TERMS -- DEFINITION OF THE PERIPHERAL NERVOUS SYSTEM (PNS) -- RELATIONSHIPS FUNDAMENTAL TO AN UNDERSTANDING OF DISEASE OF PERIPHERAL NERVE FIBERS -- Neuron Cell Body and Axon -- Axon, Schwann Cell, and Myelin -- Axon and End Organ -- Wallerian Degeneration and Axon Regeneration -- GLOSSARY OF COMMON CLINICAL TERMS -- 2. ANATOMIC CLASSIFICATION OF PERIPHERAL NERVOUS SYSTEM DISORDERS -- SYMMETRIC GENERALIZED NEUROPATHIES (POLYNEUROPATHIES) -- Distal Axonal Degeneration -- Segmental (Nonuniform) Myelinopathy -- Diffuse (Uniform) Myelinopathy -- Neuronopathy (Ganglionopathy) -- FOCAL (MONONEUROPATHY) AND MULTIFOCAL (MULTIPLE MONONEUROPATHY) NEUROPATHIES -- Ischemia -- Infiltration -- Physical Injuries -- 3. EVALUATION AND MANAGEMENT OF THE PATIENT WITH PERIPHERAL NEUROPATHY -- GENERAL PRINCIPLES AND THE ALGORITHMIC APPROACH -- CHRONIC IDIOPATHIC AXONAL POLYNEUROPATHY (CIAP)/SMALL-FIBER NEUROPATHY (SFN) -- TREATMENT OF NEUROPATHIC PAIN -- DIFFERENTIAL DIAGNOSES AND WORK-UPS FOR THE VARIED NEUROPATHY PHENOTYPES -- 4. ELECTRODIAGNOSTIC, IMAGING, NERVE, AND SKIN BIOPSY INVESTIGATIONS IN PERIPHERAL NERVE DISEASE -- ELECTROMYOGRAPHY AND NERVE CONDUCTION STUDIES -- Sensory Nerve Conduction Studies -- Motor Nerve Conduction Studies -- Late Responses -- Blink Reflex Studies -- Needle Electromyography -- STUDIES OF AUTONOMIC FUNCTION -- Quantitative Sudomotor Axon Reflex Test (QSART) -- Thermoregulatory Sweat Test (TST) -- Sympathetic Skin Response (SSR) -- Heart Rate Response to Deep Breathing -- Valsalva Maneuver -- QUANTITATIVE SENSORY TESTING (QST) -- DEVELOPING ELECTROPHYSIOLOGIC AND IMAGING TECHNIQUES -- Motor Unit Number Estimation (MUNE) -- Electrical Impedance Myography (EIM) -- High-Resolution Sonography of Peripheral Nerve -- Magnetic Resonance (MR) Neurography -- Muscle MRI.

Positron Emission Tomography (PET) -- NERVE BIOPSY -- Indications -- Technical Considerations -- SKIN BIOPSY -- 5. CASE PRESENTATIONS ILLUSTRATING THE DIAGNOSTIC METHOD -- CASE 1: PAINFUL SMALL-FIBER NEUROPATHY AND DYSAUTONOMIA -- CASE 2: INSIDIOUS ONSET OF DISTAL WEAKNESS IN AN ADULT WITH DEFORMED FEET -- CASE 3: LOWER LIMB PARESTHESIAS IN A MIDDLE-AGED ADULT WITH DIABETES -- CASE 4: A MIDDLE-AGED WOMAN WITH MUSCLE TWITCHING AND EPISODIC NUMBNESS -- CASE 5: SIX DAYS OF CRANIAL NEUROPATHIES AND HYPOREFLEXIA -- CASE 6: TWO-MONTH ONSET OF SENSORY NEUROPATHY IN A WOMAN WITH OVARIAN CARCINOMA -- CASE 7: A 47-YEAR-OLD MAN WITH 10 YEARS OF PROGRESSIVE BILATERAL HAND WEAKNESS -- CASE 8: CHRONIC SENSORY LOSS AND UNSTEADY GAIT IN A 59-YEAR-OLD WOMAN -- CASE 9: AN ELDERLY MAN WITH ACRAL PARESTHESIAS AND GAIT UNSTEADINESS -- CASE 10: FOOT DROP IN AN 81-YEAR-OLD WOMAN -- CASE 11: A MIDDLE-AGED MAN WITH MULTIFOCAL PAIN, SENSORY LOSS, AND WEAKNESS -- CASE 12: FIVE-DAY ONSET OF DIFFUSE WEAKNESS -- 6. ACUTE IMMUNE-MEDIATED NEUROPATHIES -- DEMYELINATING IMMUNE-MEDIATED NEUROPATHIES -- Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP) and Fisher Syndrome (FS) -- AXONAL IMMUNE-MEDIATED NEUROPATHIES -- Acute Motor Axonal Neuropathy (AMAN) and Acute Motor and Sensory Axonal Neuropathy (AMSAN) -- NEURONOPATHIES -- Sensory (Idiopathic, Sjögren Syndrome, Paraneoplastic) and Motor (Paraneoplastic) Neuronopathies and Autoimmune Autonomic Ganglionopathy (AAG) -- 7. CHRONIC IMMUNE-MEDIATED NEUROPATHIES -- CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY (CIDP) AND ITS VARIANTS -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology -- Pathogenesis -- Treatment -- Course and Prognosis -- 8. NEUROPATHIES ASSOCIATED WITH MONOCLONAL GAMMOPATHIES AND CANCER.

MULTIPLE MYELOMA, OSTEOSCLEROTIC MYELOMA, PRIMARY SYSTEMIC AMYLOIDOSIS (AL AMYLOIDOSIS), WALDENSTRÖM MACROGLOBULINEMIA, MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- 9. INFECTIOUS AND GRANULOMATOUS NEUROPATHIES -- INTRODUCTION -- HERPES ZOSTER/HERPES SIMPLEX -- Clinical Features -- Pathology -- Treatment, Course, and Prognosis -- LEPROSY -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment -- Course and Prognosis -- SARCOIDOSIS -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- LYME DISEASE -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- HUMAN IMMUNODEFICIENCY VIRUS (HIV)-RELATED PERIPHERAL NEUROPATHIES -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment -- Course and Prognosis -- CRYOGLOBULINEMIA AND HEPATITIS C -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment -- Course and Prognosis -- DIPHTHERIA -- Clinical Features -- Laboratory Studies -- Pathology -- Treatment, Course, and Prognosis -- 10. DIABETIC AND OTHER ENDOCRINE NEUROPATHIES -- THE DIABETIC NEUROPATHIES -- Introduction -- Distal Symmetric Sensorimotor/Autonomic Polyneuropathy (DSP/A) -- Autonomic Neuropathy -- Proximal Multifocal Neuropathies (Diabetic Lumbosacral Radiculoplexus Neuropathy and Thoracolumbar Truncal Neuropathy) -- Focal Limb Neuropathies (Entrapment Neuropathies) -- Isolated Cranial Neuropathies -- Acute Painful Neuropathy (Diabetic Neuropathic Cachexia) -- Diabetic Motor-Predominant Neuropathies -- Treatment-Induced Neuropathy (Insulin Neuritis).

Hyperglycemic Neuropathy -- ACROMEGALIC NEUROPATHY -- Introduction -- Mononeuropathy -- Distal Symmetric Polyneuropathy -- HYPOTHYROID NEUROPATHY -- Introduction -- Mononeuropathy -- Distal Symmetric Polyneuropathy -- 11. NEUROPATHIES ASSOCIATED WITH VITAMIN AND ESSENTIAL MINERAL DEFICIENCIES AND MALABSORPTION -- INTRODUCTION -- VITAMIN B[sub(12)] (COBALAMIN) DEFICIENCY -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- VITAMIN B[sub(1)] (THIAMINE) DEFICIENCY -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- CELIAC DISEASE -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- VITAMIN E (ɑ-TOCOPHEROL) DEFICIENCY -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- COPPER DEFICIENCY -- Clinical Features -- Laboratory Studies -- Nerve Biopsy/Pathology -- Pathogenesis -- Treatment, Course, and Prognosis -- OTHER: CUBAN EPIDEMIC OPTIC AND PERIPHERAL NEUROPATHY -- DEFICIENCIES: RIBOFLAVIN (VITAMIN B[sub(2)], PYRIDOXINE (VITAMIN B[sub(6)], FOLATE, ZINC -- BARIATRIC SURGERY -- 12. VASCULAR/ISCHEMIC NEUROPATHIES -- VASCULITIC NEUROPATHIES -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology/Nerve Biopsy -- Pathogenesis -- Treatment, Course, and Prognosis -- NEUROPATHIES ASSOCIATED WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE -- NEUROPATHIES ASSOCIATED WITH COMPARTMENT SYNDROMES -- 13. NEUROPATHIES ASSOCIATED WITH ORGAN FAILURE -- PULMONARY FAILURE -- HEPATIC FAILURE -- RENAL FAILURE -- Uremic Polyneuropathy -- Mononeuropathies -- Ischemic Monomelic Neuropathy -- ORGAN TRANSPLANTATION -- CRITICAL ILLNESS POLYNEUROPATHY -- Differential Diagnosis.

14. THE HEREDITARY NEUROPATHIES -- HEREDITARY MOTOR AND SENSORY NEUROPATHIES (HMSN)/CHARCOT-MARIE-TOOTH DISEASE (CMT) -- Introduction -- Charcot-Marie-Tooth Disease, Type 1 (CMT1/HMSN I) -- Hereditary Neuropathy with Liability to Pressure Palsy (HNPP) -- Charcot-Marie- Tooth Disease, Type 2 (CMT2/HMSN II) -- Additional Autosomal Recessive Axonal Neuropathies -- Dejerine-Sottas Disease and Congenital Hypomyelinating Neuropathy (HMSN III) -- Charcot-Marie-Tooth Disease, Type 4 (CMT4, Autosomal Recessive CMT1, ARCMT1, HMSN IV) -- Charcot-Marie-Tooth Disease, X-Linked (CMTX/HMSN X) -- Charcot-Marie-Tooth Disease, Dominant Intermediate (DI-CMT) -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES (HSAN) -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology -- Pathophysiology -- Treatment, Course, and Prognosis -- DISTAL HEREDITARY MOTOR NEUROPATHIES/NEURONOPATHIES (dHMN) -- HEREDITARY ATAXIA WITH NEUROPATHY -- Autosomal Dominant -- Autosomal Recessive -- X-Linked -- HEREDITARY SPASTIC PARAPLEGIA WITH NEUROPATHY (HSP) -- HEREDITARY BRACHIAL PLEXUS NEUROPATHY (HBPN)/ HEREDITARY NEURALGIC AMYOTROPHY (HNA) -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology/Pathophysiology -- Treatment, Course, and Prognosis -- HEREDITARY PERIPHERAL NERVE CHANNELOPATHIES -- Sodium Channelopathies -- Potassium Channelopathies -- 15. HEREDITARY METABOLIC/MULTISYSTEM DISORDERS WITH NEUROPATHY -- FAMILIAL AMYLOID POLYNEUROPATHIES -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology -- Pathophysiology -- Treatment, Course, and Prognosis -- DISORDERS OF LIPID METABOLISM -- Lysosomal Disorders -- Peroxisomal Disorders -- Lipoprotein Deficiencies -- Cerebrotendinous Xanthomatosis -- PORPHYRIA -- Introduction -- Clinical Features -- Laboratory Studies -- Pathology -- Pathophysiology -- Treatment, Course, and Prognosis.

DISORDERS OF DEFECTIVE DNA REPAIR.