Front Cover -- Manual of Pediatric Hematology and Oncology -- Copyright Page -- Contents -- Dedication -- Contributors -- Introduction -- Preface to the Fifth Edition -- Preface to the Fourth Edition -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Chapter 1. Classification and Diagnosis of Anemia in Children -- Suggested Reading -- Chapter 2. Anemia During the Neonatal Period -- Hemorrhage -- Hemolytic Anemia -- Failure of Red Cell Production -- Anemia of Prematurity -- Physiologic Anemia -- Diagnostic Approach to Anemia in the Newborn -- Suggested Reading -- Chapter 3. Iron-Deficiency Anemia -- Prevalence -- Etiologic Factors -- Non-Hematological Manifestations -- Diagnosis -- Treatment -- Suggested Reading -- Chapter 4. Megaloblastic Anemia -- Vitamin B[sub(12)] (Cobalamin) Deficiency -- Folic Acid Deficiency -- General Clinical Features of Cobalamin and Folate Deficiency -- Diagnosis -- Treatment -- Suggested Reading -- Chapter 5. Hematologic Manifestations of Systemic Illness -- Hematologic Manifestations of Diseases of Various Organs -- Chronic Illness -- Lead Intoxication -- Nutritional Disorders -- Bone Marrow Infiltration -- Suggested Reading -- Chapter 6. Bone Marrow Failure -- Aplastic Anemia -- Acquired Aplastic Anemia -- Congenital Aplastic Anemias -- Dyskeratosis congenita -- Congenital Aplastic Anemias of Unknown Inheritance -- Diamond-Blackfan Anemia (Congenital Pure Red Cell Aplasia) -- Transient Erythroblastopenia -- Congenital Dyserythropoietic Anemia (CDA) -- Sideroblastic Anemias (Mitochondrial Diseases with Bone Marrow Failure Syndromes) -- Suggested Reading -- Chapter 7. Red Cell Membrane and Enzyme Defects -- General Approach to Diagnosis of Hemolytic Anemia -- Membrane Defects -- Paroxysmal Nocturnal Hemogloginuria -- Enzyme Defects -- Suggested Reading.

Chapter 8. Hemoglobinopathies -- Sickle Cell Disease -- Unstable Hemoglobins -- Thalassemias -- β-Thalassemia: Homozygous or Doubly Heterozygous Forms (Major and Intermedia) -- β-Thalassemia Intermedia -- β-Thalassemia Minor or Trait (Heterozygous β[sup(0)] or β+) -- α-Thalassemias -- Suggested Reading -- Chapter 9. Extracorpuscular Hemolytic Anemia -- Immune Hemolytic Anemia -- Nonimmune Hemolytic Anemia -- Suggested Reading -- Chapter 10. Polycythemia -- Polycythemia (Erythrocytosis) in the Newborn -- Polycythemia in Childhood -- Polycythemia Vera -- Primary Familial and Congenital Polycythemia -- Congenital Polycythemia Due to Altered Hypoxia Sensing with Normal P50 -- Prolyl Hydroxylase Domain (PHD) 2 Mutations -- Congenital Polycythemia Due to Altered Hypoxia Sensing with Decreased P50 -- Other Causes of Polycythemia -- Diagnostic Approach -- Suggested Reading -- Chapter 11. Disorders of White Blood Cells -- Quantitative Disorders of Leukocytes -- Decreased Polymorphonuclear Leukocyte Production -- Increased Destruction or Disorders of Distribution of Polymorphonuclear Leukocytes -- Eosinophils -- Lymphocytes -- Neutrophil Production and Destruction in Newborn Infants -- Suggested Reading -- Chapter 12. Disorders of Platelets -- Thrombocytopenia in the Newborn -- Inherited Thrombocytopenias -- Thrombocytopenia in Childhood -- Thrombocytosis -- Qualitative Platelet Disorders -- Acquired Platelet Disorders -- Inherited Vascular and Connective Tissue Disorders -- Laboratory Evaluation of Platelets and Platelet Function -- Nonthrombocytopenic Purpura -- Suggested Reading -- Chapter 13. Hemostatic Disorders -- Physiology of Hemostasis -- Fibrinolysis -- Natural Inhibitors of Coagulation -- Hemostasis in the Newborn -- Detection of Hemostatic Defects -- Acquired Coagulation Factor Disorders -- Inherited Coagulation Factor Disorders.

Rare Inherited Coagulation Factor Disorders (Factor II, V, VII, X, XIII, Fibrinogen Deficiencies) -- Hereditary Disorders of Platelet Function -- Suggested Reading -- Chapter 14. Thrombotic Disorders -- Mechanisms of Thrombosis in Inherited Thrombophilia -- Venous Thrombosis -- Arterial Thrombosis -- Antiphospholipid Syndrome -- Hereditary Thrombotic Disorders -- Thrombotic Disorders in Newborns -- Antithrombotic Agents -- Heparin-induced Thrombocytopenia -- Thrombolytic Therapy -- Antithrombotic Therapy in Special Conditions -- Suggested Reading -- Chapter 15. Lymphadenopathy and Splenomegaly -- Lymphadenopathy -- Splenomegaly -- Suggested Reading -- Chapter 16. Lymphoproliferative Disorders, Myelodysplastic Syndromes and Myeloproliferative Disorders -- Lymphoproliferative Disorders -- Myelodysplastic Syndrome -- Juvenile Myelomonocytic Leukemia (JMML) -- Chronic Myeloproliferative Diseases -- Chronic Myeloid Leukemia (CML) -- Suggested Reading -- Chapter 17. Leukemias -- Incidence -- Etiology -- Clinical Features of Acute Lymphoblastic Leukemia (ALL) -- Acute Myeloid Leukemia -- Suggested Reading -- Chapter 18. Histiocytosis Syndromes -- Langerhans Cell Histiocytosis -- Other Histiocytic Disorders -- Dermal Dendrocyte Disorders -- Suggested Reading -- Chapter 19. Hodgkin Lymphoma -- Etiology and Epidemiology -- Risk Factors -- Biology -- Pathology -- Clinical Presentation -- Diagnostic Evaluation and Staging -- Prognostic Factors -- Treatment -- Long-term Complications -- Follow-up Evaluations -- Suggested Reading -- Chapter 20. Non-Hodgkin Lymphoma -- Introduction -- Incidence and Epidemiology -- Pathologic Classification -- Clinical Features -- Diagnosis -- Staging -- Management -- Lymphoblastic Lymphoma -- B lineage NHL (BC, BLL and DLCL) -- Suggested Reading -- Chapter 21. Central Nervous System Malignancies -- Pathology.

Clinical Manifestations -- Diagnostic Evaluation -- Treatment -- Astrocytomas -- Medulloblastoma -- Brain Stem Tumors -- Ependymomas -- Optic Glioma -- Craniopharyngiomas -- Intracranial Germ Cell Tumors -- Malignant Brain Tumors in Infants and Children Less than 3 Years of Age -- Suggested Reading -- Chapter 22. Neuroblastoma -- Epidemiology -- Predisposition -- Pathology and Biology -- Clinical Features -- Neuroblastoma in the Neonate -- Diagnosis and Staging -- Prognosis and Risk Stratification -- Treatment -- Disease Stratification and Therapy -- Post-Therapy Monitoring -- Special Treatment Considerations -- Neuroblastoma in the Adolescent and Young Adult -- Suggested Reading -- Chapter 23. Renal Tumors -- Wilms' Tumor -- Nephroblastomatosis -- Congenital Mesoblastic Nephroma -- Clear Cell Sarcoma of the Kidney -- Rhabdoid Tumor of the Kidney -- Renal Cell Carcinoma (RCC) -- Suggested Reading -- Chapter 24. Rhabdomyosarcoma and Other Soft-Tissue Sarcomas -- Incidence and Epidemiology -- Pathologic Classification -- Genetics -- Clinical Features -- Diagnostic Evaluation -- Staging -- Prognosis -- Treatment -- Follow-Up After Completion of Therapy -- Recurrent Disease -- Future Perspectives -- Suggested Reading -- Chapter 25. Malignant Bone Tumors -- Osteosarcoma -- Ewing Sarcoma -- Suggested Reading -- Chapter 26. Retinoblastoma -- Incidence -- Classification -- Other Epidemiologic Data -- Risk for Second Malignant Neoplasms (SMN) -- Pathology -- Clinical Features -- Diagnostic Procedures -- Staging -- Treatment -- Post-Treatment Management -- Future Perspectives -- Suggested Reading -- Chapter 27. Germ Cell Tumors -- Incidence -- Pathology -- Clinical Features -- Diagnostic Evaluation -- Tumor Markers -- Staging -- Treatment -- Relapsed and Resistant Germ Cell Tumors -- Suggested Reading -- Chapter 28. Hepatic Tumors -- Incidence -- Epidemiology.

Pathology -- Clinical Features -- Diagnostic Evaluation -- Staging -- Treatment -- Prognosis -- Suggested Reading -- Chapter 29. Hematopoietic Stem Cell Transplantation -- Solid Tumors -- Allogeneic Stem Cell Transplantation -- Engraftment -- Graft Versus Host Disease (GVHD) -- Autologous Stem Cell Transplantation -- Complications of Hematopoietic Stem Cell Transplantation -- Late Sequelae of Stem Cell Transplantation -- Post-Stem Cell Transplantation Therapy -- Suggested Reading -- Chapter 30. Management of Oncologic Emergencies -- Metabolic and Endocrine Emergencies -- Oncologic Emergencies by Anatomic Region -- Suggested Reading -- Chapter 31. Supportive Care of Patients with Cancer -- Management of Infectious Complications -- Bacterial Infections -- Fungal Infections -- Viral Infections -- Protozoan Infections -- G-CSF and Granulocyte Infusions -- Immunizations -- Blood Component Therapy -- Hematopoietic Growth Factors: Basic Biology of Growth Factors -- Clinical use of G-CSF, GM-CSF, Erythropoietin and IL-11 -- Prevention of Organ Toxicity -- Pain Management -- General Guidelines for Management of Pain in Oncology Patients -- Management of Nausea and Vomiting -- Nutritional Support -- Psychosocial Support and End-of-Life Care -- Suggested Reading -- Chapter 32. Evaluation, Investigations and Management of Late Effects of Childhood Cancer -- Musculoskeletal Dysfunction -- Cardiovascular Disorders -- Respiratory System -- Central Nervous System -- Endocrine System -- Genitourinary System -- Ocular System -- Auditory System -- Gastrointestinal System -- Immunologic System -- Obesity -- Second Malignant Neoplasms -- Suggested Reading -- Chapter 33. Psychosocial Aspects of Cancer for Children and their Families -- Diagnosis -- Treatment Initiation -- Illness Stabilization -- Relapses and Recurrences -- Treatment Outcomes: The Unsuccessful Course.

Treatment Outcomes: The Successful Course.