Comprehensive Chromatography in Combination with Mass Spectrometry -- Contents -- Contributors -- Preface -- 1. Introduction -- 1.1 Two-Dimensional Chromatography-Mass Spectrometry: A 50-Year-Old Combination -- 1.2 Shortcomings of One-Dimensional Chromatography -- 1.3 Benefits of Two-Dimensional Chromatography -- 1.4 Book Content -- 1.5 Final Considerations -- 2. Multidimensional Gas Chromatography: Theoretical Considerations -- 2.1 Symbols -- 2.2 One-Dimensional GC -- 2.3 Comprehensive GC x GC -- 3. Multidimensional Liquid Chromatography: Theoretical Considerations -- 3.1 Two-Dimensional LC Techniques -- 3.2 Peak Capacity in HPLC: One- and Multidimensional Separations -- 3.3 Orthogonality in Two-Dimensional LC-LC Systems -- 3.4 Sample Dimensionality and Structural Correlations -- 3.5 Separation Selectivity and Selection of Phase Systems in Two-Dimensional LC-LC -- 3.6 Programmed Elution in Two-Dimensional HPLC -- 3.7 Fraction Transfer Modulation in Comprehensive LC x LC: Additional Band Broadening -- 3.8 Future Perspectives -- 4. History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Gas Chromatography -- 4.1 Fundamentals of GC x GC -- 4.2 Modulation -- 4.3 GC x GC Data Interpretation -- 4.4 GC x GC Instrumentation -- 4.5 Thermal Modulators -- 4.6 Comprehensive Two-Dimensional GC Method Optimization -- 4.7 Final Remarks -- 5. Flow-Modulated Comprehensive Two-Dimensional Gas Chromatography -- 5.1 Timing Requirements of GC x GC Modulators -- 5.2 Criteria for Evaluating Modulators -- 5.3 Forms of Modulation -- 5.4 Single-Stage Flow Modulation -- 5.5 Two-Stage Flow Modulation -- 5.6 Summary of Flow Modulators -- 5.7 Brief Comparison to Thermal Modulation -- 5.8 Concluding Remarks -- 6. Comprehensive Two-Dimensional Gas Chromatography Combined with Mass Spectrometry -- 6.1 Instrument Requirements for GC x GC-MS.

6.2 Data Processing of GC x GC-TOF MS Results -- 6.3 Method Translation in GC x GC-MS -- 6.4 GC x MS -- 6.5 Conventional and Alternative Modulation Techniques for GC x GC-MS -- 6.6 GC x GC-MS Applications -- 6.7 Concluding Remarks -- 7. Detector Technologies and Applications in Comprehensive Two-Dimensional Gas Chromatography -- 7.1 Detection in GC x GC -- 7.2 Comments on GC x GC with Mass Spectrometry -- 7.3 Flame Ionization Detection in GC x GC -- 7.4 Electron Capture Detection in GC x GC -- 7.5 Sulfur Chemiluminescence Detection in GC x GC -- 7.6 Nitrogen Chemiluminescence Detection in GC x GC -- 7.7 Atomic Emission Detection in GC x GC -- 7.8 Thermionic Detection in GC x GC -- 7.9 Flame Photometric Detection in GC x GC -- 7.10 Case Study of GC x GC with Selective Detection -- 7.11 Dual Detection with GC x GC -- 7.12 Conclusions -- 8. History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Liquid Chromatography -- 8.1 Method Development and Instrumentation -- 8.2 Technical Problems in Comprehensive Liquid Chromatography -- 8.3 Detection -- 8.4 Data Representation -- 8.5 Instrumentation -- 8.6 Milestones in Comprehensive Liquid Chromatography -- 8.7 Applications -- 8.8 Beyond Two-Dimensional Chromatography -- 8.9 Comparison of LC x LC and Off-Line 2D LC -- 8.10 Conclusions -- 9. Comprehensive Two-Dimensional Liquid Chromatography Combined with Mass Spectrometry -- 9.1 HPLC-MS -- 9.2 LC x LC-MS Instrumentation and Method Development -- 9.3 LC x LC-MS Applications -- 10. Comprehensive Two-Dimensional Liquid Chromatography Applications -- 10.1 Comprehensive 2D LC Separation of Synthetic and Natural Polymers -- 10.2 Comprehensive 2D LC Separation of Natural Products and Antioxidants -- 10.3 Comprehensive 2D LC Separation of Pharmaceutical and Environmental Compounds -- 10.4 Comprehensive 2D LC Separation of Proteins and Peptides.

11. Other Comprehensive Chromatography Methods -- 11.1 Online Two-Dimensional Liquid Chromatography-Gas Chromatography -- 11.2 Online Two-Dimensional Supercritical Fluid Chromatography-Gas Chromatography -- 11.3 Online Two-Dimensional Supercritical Fluid Chromatography-Supercritical Fluid Chromatography -- 11.4 Online Two-Dimensional Supercritical Fluid Chromatography-Liquid Chromatography -- 12. Comprehensive Chromatography Data Interpretation Technologies -- 12.1 Higher-Order Data Structure -- 12.2 Modifications of First-Order Data-Handling Approaches -- 12.3 Visualization -- 12.4 Mass Spectral Detection -- 12.5 Chemometrics -- 12.6 Summary of Data Interpretation Technologies -- Index.