Medicinal Chemistry of Nucleic Acids.
Title:
Medicinal Chemistry of Nucleic Acids.
Author:
Zhang, Li-He.
ISBN:
9781118092835
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (466 pages)
Series:
Wiley Series in Drug Discovery and Development ; v.16
Wiley Series in Drug Discovery and Development
Contents:
MEDICINAL CHEMISTRY OF NUCLEIC ACIDS -- CONTENTS -- FOREWORD -- CONTRIBUTORS -- INTRODUCTION -- 1 RECENT ADVANCES IN CARBOCYCLIC NUCLEOSIDES: SYNTHESIS AND BIOLOGICAL ACTIVITY -- 2 STRUCTURES AND FUNCTIONS OF NUCLEIC ACIDS MODIFIED WITH S, Se, AND Te AND COMPLEXED WITH SMALL MOLECULES -- 3 UNRAVELING OF THE NAD CYCLIZING AND CALCIUM SIGNALING FUNCTIONS OF HUMAN CD38 -- 4 DNA AND RNA BINDING SMALL MOLECULES -- 5 G-QUADRUPLEX DNA AND ITS LIGANDS IN ANTICANCER THERAPY -- 6 MOLECULAR MODELING IN NUCLEIC ACID-TARGETED DRUG DESIGN -- 7 STRUCTURE OF 10-23 DNAzyme IN COMPLEX WITH THE TARGET RNA IN SILICO-A PROGRESS REPORT ON THE MECHANISM OF RNA CLEAVAGE BY DNA ENZYME -- 8 LABELING OLIGONUCLEOTIDES TOWARD THE BIOMEDICAL PROBE -- 9 LOCKED NUCLEIC ACID OLIGONUCLEOTIDES TOWARD CLINICAL APPLICATIONS -- 10 THE PHARMACOKINETICS RESEARCH OF NUCLEIC ACID DRUGS -- 11 INDUCIBLE RNAi AND DRUG TARGET VALIDATION -- 12 siRNA: THE SPECIFICITY AND OFF-TARGET EFFECTS -- INDEX.
Abstract:
Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry-a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids-such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs-to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research-and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
Genre:
Electronic Access:
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