Biological Petri Nets.
Title:
Biological Petri Nets.
Author:
Wingender, E.
ISBN:
9781607507048
Personal Author:
Physical Description:
1 online resource (316 pages)
Series:
Studies in Health Technology and Informatics ; v.162
Studies in Health Technology and Informatics
Contents:
Title page -- Preface -- Contents -- Petri Nets and the Simulation of Metabolic Networks -- Quantitative Modeling of Biochemical Networks -- Topological Analysis of Metabolic Networks Based on Petri Net Theory -- Quantitative Petri Net Model of Gene Regulated Metabolic Networks in the Cell -- Petri Nets for Steady State Analysis of Metabolic Systems -- Biopathways Representation and Simulation on Hybrid Functional Petri Net -- Constructing Biological Pathway Models with Hybrid Functional Petri Nets -- STEPP - Search Tool for Exploration of Petri Net Paths: A New Tool for Petri Net-Based Path Analysis in Biochemical Networks -- Ontology Based Standardization of Petri Net Modeling for Signaling Pathways -- Simulation-Based Validation of the p53 Transcriptional Activity with Hybrid Functional Petri Net -- Analyzing Stationary States of Gene Regulatory Network Using Petri Nets -- Cell Illustrator 4.0: A Computational Platform for Systems Biology -- Modeling of Cell-to-Cell Communication Processes with Petri Nets Using the Example of Quorum Sensing -- On Determining Firing Delay Time of Transitions for Petri Net Based Signaling Pathways by Introducing Stochastic Decision Rules -- Impact of Delays and Noise on Dopamine Signal Transduction -- Role of mRNA Gestation and Senescence in Noise Reduction During the Cell Cycle -- Exhaustive Analysis of the Modular Structure of the Spliceosomal Assembly Network: A Petri Net Approach -- Modelling the Molecular Interactions in the Flower Developmental Network of Arabidopsis Thaliana -- Subject Index -- Author Index.
Abstract:
It was suggested some years ago that Petri nets might be well suited to modeling metabolic networks, overcoming some of the limitations encountered by the use of systems employing ODEs (ordinary differential equations). Much work has been done since then which confirms this and demonstrates the usefulness of this concept for systems biology. Petri net technology is not only intuitively understood by scientists trained in the life sciences, it also has a robust mathematical foundation and provides the required degree of flexibility. As a result it appears to be a very promising approach to modeling biological systems.This unique compilation of articles is the first book from the journal In Silico Biology (ISB) on Biological Petri Nets. Subjects covered include a summary of essential topics, basic requirements and constraints; quantitative modeling of metabolic networks, gene regulatory and cell-cell communication processes; the concept of hybrid Petri nets; modeling signal transduction pathways; net models of metabolic steady states as well as a number of further applications of Petri net based modeling.The book helps to illustrate the value of Petri net approach to modern life sciences. It is dedicated to the memory of Prof. Dr. Carl Adam Petri.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
Genre:
Electronic Access:
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