EVOLUTIONARY BIOLOGY, CELL-CELL COMMUNICATION, AND COMPLEX DISEASE -- CONTENTS -- PREFACE -- ABOUT THE AUTHORS -- 1: THE CELLULAR ORIGIN OF VERTEBRATES -- THE ORIGINS OF UNICELLULAR LIFE ON EARTH -- PROKARYOTES VERSUS EUKARYOTES -- COEVOLUTION OF TRAITS -- CHOLESTEROL FACILITATES LIPID RAFTS FOR CELL-CELL COMMUNICATION -- THE ENDOMEMBRANE SYSTEM -- THE CELLULAR MECHANISM OF EVOLUTION -- WHY EVOLVE? -- CELL-CELL COMMUNICATION AND AGING -- 2: REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES -- HORMONAL ACCELERATION OF LUNG DEVELOPMENT -- NEUTRAL LIPID TRAFFICKING AND LUNG EVOLUTION -- OTHER EXAMPLES OF CELLULAR COOPERATIVITY -- SUMMARY -- 3: A CELL-MOLECULAR STRATEGY TO SOLVING THE EVOLUTIONARY PUZZLE -- RATIONALE FOR CELL-MOLECULAR EVOLUTION -- MECHANISM OF MAMMALIAN LUNG DEVELOPMENT -- AVIAN LUNG STRUCTURE-FUNCTION RELATIONSHIP: THE EXCEPTION THAT PROVES THE RULE -- DOES ONTOGENY RECAPITULATE PHYLOGENY? THE ROLE OF PTHRP IN LUNG DEVELOPMENT -- INTERRELATIONSHIP BETWEEN PTHRP, DEVELOPMENT, PHYSIOLOGY, AND REPAIR: IS REPAIR A RECAPITULATION OF ONTOGENY AND PHYLOGENY? -- 4: THE EVOLUTION OF CELL-CELL COMMUNICATION -- CELL-CELL COMMUNICATION AS THE MECHANISTIC BASIS FOR EVOLUTIONARY BIOLOGY -- THE DARWINIAN BIOLOGIC SPACETIME CONTINUUM AND EINSTEIN'S VISION OF THE UNIVERSE -- REVERSE ENGINEERING OF PHYSIOLOGIC TRAITS AS A PORTAL FOR VIEWING EVOLUTION -- CELL-CELL COMMUNICATION AS THE BASIS FOR THE EVOLUTION OF METAZOANS -- UNDERSTANDING LUNG EVOLUTION FROM THE MIDDLE OUT -- THE CELL-CELL COMMUNICATION MODEL OF LUNG EVOLUTION TRACES CONTEMPORARY PHENOTYPES BACK TO ANCESTRAL PHENOTYPES -- PREDICTIVE VALUE OF THE LUNG CELL-CELL COMMUNICATION MODEL FOR UNDERSTANDING THE EVOLUTION OF PHYSIOLOGIC SYSTEMS -- SEXUAL DIMORPHISM OF LUNG DEVELOPMENT: A CASE STUDY IN CELL-CELL COMMUNICATION AND EVOLUTIONARY PLASTICITY.

ANDROGEN AFFECTS THE EXPRESSION OF GROWTH FACTORS INVOLVED IN LUNG DEVELOPMENT -- EVIDENCE FOR AN ASSOCIATION BETWEEN STEROID-RESISTANT/RESPONSIVE PHENOTYPES AND HUMAN LYMPHOCYTE ANTIGEN (HLA) HAPLOTYPES -- 5: HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING LINKS -- NEUTRAL THEORY VERSUS INTELLIGENT DESIGN -- INTERNAL SELECTION THEORY -- THE COUNTERINTUITIVE NATURE OF PHYSIOLOGY AND SOLUTION TO THE DEAD SEA SCROLLS PUZZLE -- THE CONTINUUM FROM MICROEVOLUTION TO MACROEVOLUTION -- cis REGULATION AND ADAPTIVE EVOLUTION -- EVOLUTION OF cis REGULATORY MECHANISMS -- 6: FROM CELL-CELL COMMUNICATION TO THE EVOLUTION OF INTEGRATED PHYSIOLOGY -- CELL-CELL SIGNALING AND ALVEOLAR DEVELOPMENT: A REDUCTIONIST APPROACH TO THE EVOLUTION OF PHYSIOLOGIC TRAITS -- AN INTEGRATED, EMPIRIC, MIDDLE-OUT APPROACH TO PHYSIOLOGY -- A MOLECULAR EVOLUTIONARY LINK BETWEEN THE LUNG AND THE KIDNEY? -- THE BERNER HYPOTHESIS AND EMERGENCE OF THE ADIPOCYTE: THE EVOLUTIONARY ORIGINS OF THE LIPOFIBROBLAST -- LUNG BIOLOGY AS A CIPHER FOR EVOLUTION -- DO STRETCH EFFECTS ON PTHRP EXPRESSION REFLECT ITS ROLE IN ADAPTING TO GRAVITY? -- WOLFF'S LAW WORKS FOR BOTH BONE AND LUNG -- FUNCTIONAL RELATIONSHIP BETWEEN THE EXTERNAL AND INTERNAL ENVIRONMENTS -- AN EVOLUTIONARY VERTICAL INTEGRATION OF THE PHYLOGENY AND ONTOGENY OF THE THYROID -- 7: EXPLOITING CELL-CELL COMMUNICATION ACROSS SPACETIME TO DECONSTRUCT EVOLUTION -- SOMEWHERE BETWEEN THE GENE AND THE PHENOTYPE LIES THE PROCESS OF EVOLUTION -- A FUNCTIONAL GENOMIC APPROACH TO EVOLUTION AS AN EXAMPLE OF TERMINAL ADDITION -- SEEKING DEEP HOMOLOGIES IN LUNG EVOLUTION -- SYSTEMS BIOLOGY BASED ON CELL-CELL COMMUNICATION -- VERTICAL INTEGRATION OF LEPTIN SIGNALING, HUMAN EVOLUTION, AND THE TROJAN HORSE EFFECT -- LEPTIN AND HUMAN EVOLUTION: FOOD FOR THOUGHT -- 8: THE PERIODIC TABLE OF BIOLOGY.

THE PROSPECT OF A PERIODIC TABLE OF BIOLOGY -- CELLULAR COOPERATION IS KEY -- ELEMENTAL BIOLOGY -- PTHRP AS AN ARCHETYPE -- EVOLUTION AS THE SOLUTION -- RAMPING UP A MATHEMATICAL MODEL OF EVOLUTION -- THE ANTHROPIC PRINCIPLE RESULTS FROM THE EVOLUTION OF CELL-CELL INTERACTIONS -- 9: VALUE ADDED BY THINKING IN TERMS OF THE CELL-CELL COMMUNICATION MODEL FOR EVOLUTION -- THIS IS NOT A JUST-SO STORY -- BEYOND GENOMICS -- FROM FAT CELLS TO INTEGRATED PHYSIOLOGY -- MOLECULAR HOMOLOGIES DISTINGUISH BETWEEN THE EVOLUTIONARY FOREST AND TREES -- THE OXYGEN-CHOLESTEROL-SURFACTANT-MEMBRANE CONNECTION -- CHOLESTEROL METABOLISM AS THE DATA OPERATING SYSTEM FOR VERTEBRATE BIOLOGY? -- TRANSLATION OF GENOMICS INTO THE PERIODIC TABLE FOR BIOLOGY -- DEEP HOMOLOGIES -- SELECTION PRESSURE FOR CELL-CELL COMMUNICATION: THE KEY TO UNDERSTANDING EVOLUTION -- 10: CELL-CELL COMMUNICATION AS THE BASIS FOR PRACTICING CLINICAL MEDICINE -- CELL-CELL COMMUNICATION MAINTENANCE AND BREAKDOWN REPRESENT HEALTH AND DISEASE, RESPECTIVELY -- CELL-CELL COMMUNICATIONS AS A FRAMEWORK FOR HUMAN EVOLUTION -- CANALIZATION, DECANALIZATION, AND THE HOLISTIC APPROACH TO THE PRACTICE OF MEDICINE -- EXPLOITING LUNG EVOLUTION TO PREVENT AND TREAT CHRONIC LUNG DISEASE -- LUNG EVOLUTION EXPLAINS THE MAGIC OF CONTINUOUS POSITIVE AIRWAY PRESSURE -- THE PARADOX OF INFECTING THE LUNG IN ORDER TO TREAT LUNG DISEASE CAUSED BY INFECTION -- EXPLOITING LUNG EVOLUTION TO PREVENT AND TREAT SMOKING-RELATED LUNG DAMAGE -- THE TROJAN HORSE EFFECT OF CANALIZATION -- IMPETUS FOR EVOLUTIONARY SCIENCE AS AN INTEGRAL PART OF THE CLINICAL CURRICULUM -- APPLICATION OF EVOLUTIONARY SCIENCE TO BIOETHICS -- EVOLUTIONARY SCIENCE, A BIOLOGIC PERIODIC TABLE, AND A UNIFIED THEORY OF BIOLOGY -- SUMMARY -- NAME INDEX -- SUBJECT INDEX.