Cover -- Halftitle -- Editorial Board -- Title -- Copyright -- Contents -- Foreword -- Preface -- Contributors -- Intensity-Modulated Radiotherapy for Gynecologic Malignancies -- ABSTRACT -- INTRODUCTION -- PELVIC RT -- Dosimetric Studies -- Treatment Planning and Delivery -- Toxicity and Outcomes -- EXTENDED-FIELD RT -- Dosimetric Studies -- Treatment Planning and Delivery -- Toxicity and Outcomes -- PELVIC-INGUINAL RT -- Dosimetric Studies, Treatment Planning,and Delivery -- Toxicity and Outcomes -- WHOLE-ABDOMINAL RT -- Dosimetric Studies -- Treatment Planning and Delivery -- Toxicity and Outcomes -- NOVEL IMRT APPLICATIONS -- Bone-Marrow-Sparing IMRT -- IMRT as an Alternative to Brachytherapy -- Simultaneous Integrated Boost -- Stereotactic Body RT -- NTER- AND INTRAFRACTION MOTION -- CONCLUSION AND FUTURE DIRECTIONS -- REFERENCES -- In-Room Image-Guided Radiation Therapy for Cervical Cancers -- ABSTRACT -- INTRODUCTION -- IMAGE-GUIDED CTV TARGET DELINEATION FOR EXTERNAL BEAM RADIATION THERAPY -- Postoperative Cervix -- Intact Cervix -- IMAGE-GUIDED PTV MARGINS FOR EXTERNAL BEAM RADIATION THERAPY -- Postoperative Cervix -- Intact Cervix -- IMAGE-GUIDED TARGET DELINEATION FOR BRACHYTHERAPY -- IMAGE-GUIDED TREATMENT DELIVERY -- CLINICAL APPLICATIONS OF IN-ROOM IGRT TECHNOLOGIES -- FUTURE DIRECTIONS -- CONCLUSIONS -- REFERENCES -- Image-Guided Brachytherapy in Cervical Cancer -- ABSTRACT -- INTRODUCTION -- ROLE OF IMAGE-GUIDED BRACHYTHERAPY VERSUS ANEBRT BOOST -- DOSE RATE AND GENERAL RADIOBIOLOGIC PRINCIPLES -- IMAGING MODALITIES USED IN IMAGE-GUIDED BRACHYTHERAPY -- Ultrasound -- Computed Tomography -- Magnetic Resonance Imaging -- Positron Emission Tomography -- Contouring and Dosimetric Nomenclature -- Timing and Recommended Doses -- CLINICAL OUTCOMES -- Applicator: Tandem and Ring/Tandem and Ovoid/Mould -- Toxicities.

Applicator: Template-Based Interstitial -- CONCLUSION -- REFERENCES -- Intensity-Modulated Radiotherapy in Vulvar Cancer -- ABSTRACT -- INTRODUCTION -- CLINICAL ASSESSMENT -- IMMOBILIZATION AND TREATMENT PLANNING -- CONTOURS -- Target Volumes -- OAR -- IMRT Planning and Dose Selection -- Image-Guided Radiotherapy -- DOSIMETRIC STUDIES -- CLINICAL IMPLEMENTATION -- Adjuvant RT -- Locally Advanced Disease -- CONCLUSIONS -- REFERENCES -- Chemotherapy in Advanced/Recurrent Endometrial Cancer -- ABSTRACT -- INTRODUCTION -- ADJUVANT THERAPY: ADVANCED DISEASE -- HORMONAL THERAPY IN ADVANCED/RECURRENT ENDOMETRIAL CANCER: NO PRIOR CHEMOTHERAPY -- HEMOTHERAPY IN ADVANCED/RECURRENT ENDOMETRIAL CANCER -- Single-Agent Studies: No Prior Chemotherapy -- Phase II Studies -- Phase III Studies -- DEVELOPMENTAL THERAPEUTICS IN ADVANCED/RECURRENT ENDOMETRIAL CANCER -- REFERENCES -- Biologic Agents and Immune Therapy in Gynecologic Cancers -- ABSTRACT -- INTRODUCTION -- ANTIANGIOGENIC AGENTS -- Bevacizumab -- Afl ibercept -- Sunitinib -- Pazopanib -- Brivanib -- Other TKI -- EGFR INHIBITORS -- Monoclonal Antibody Inhibitors to EGFR -- Small Molecule Inhibitors -- Multitargeted TKIs -- INHIBITORS OF THE PI3-KINASE/AKT/MTOR PATHWAY -- Akt -- Phosphotidylinositol-3-kinase (PI3K) -- mTOR (Protein Mammalian Target of Rapamycin) -- Endometrial Cancer and PTEN -- Temsirolimus, Deforolimus, and Everolimus -- OTHER AGENTS -- Aurora Kinase Inhibitors -- PARP Inhibitors -- Hedgehog Inhibitors -- IMMUNOTHERAPY -- Monoclonal Antibody Therapy -- Adoptive Immunothera -- Tumor Vaccine Therapy -- SUMMARY -- REFERENCES -- Lymphadenectomy in Uterine Cancer -- ABSTRACT -- INTRODUCTION -- IMPORTANCE OF AND ALTERNATIVES TO LYMPHADENECTOMY -- Importance of Stage -- Preoperative Imaging and Biopsy -- Intraoperative Evaluation -- Uterine Factors as a Surrogate to Predict Nodal Disease.

THE CONTROVERSY -- Nodal Dissection-None -- Nodal Dissection-Selective -- Nodal Dissection-Routine -- Extent of Nodal Dissection -- LYMPHADENECTOMY TECHNIQUE -- Surgical Technique -- Minimally Invasive Management -- COMPLICATIONS ASSOCIATED WITH LYMPHADENECTOMY -- REFERENCES -- Robotic Surgery in Gynecologic Cancer -- ABSTRACT -- INTRODUCTION -- ADOPTION OF ROBOTIC SURGERY -- TRAINING -- CLINICAL IMPACT: ENDOMETRIUM -- CLINICAL IMPACT: CERVIX -- CLINICAL IMPACT: OVARY -- COST -- FUTURE -- REFERENCES -- Magnetic Resonance Imaging for Assessing Tumor Response in Cervical Cancer -- ABSTRACT -- INTRODUCTION -- ANATOMICAL TUMOR VOLUME ASSESSMENT BY MRI -- Tumor Volume, Volume Response Assessment, and Early Outcome Prediction -- 3D MR Volumetry for Response Assessment and Outcome Prediction -- FUNCTIONAL MRI ASSESSMENT OF CERVICAL CANCER -- DCE MRI: Rationale and Methodology -- DCE Methods -- FUNCTIONAL MRI-BASED EARLY OUTCOME PREDICTION -- Serial DCE during Therapy and Temporal Shift of DCE -- Combination of Tumor Volume and Functional Parameters for Early Outcome Prediction -- Heterogeneity Assessment of DCE -- COMBINATION OF DCE WITH OTHER MRI AND CLINICAL RESPONSE PREDICTORS -- DIFFUSION WEIGHTED IMAGING MRI -- CONCLUSIONS AND FUTURE DIRECTION -- REFERENCES -- Index -- Back Cover.