CONTENTS -- Contributors -- Preface -- 1. Chemotherapy in Gynecologic Malignancies Waleed S.W. Shalaby -- Introduction -- General Chemotherapy Principles and Terminology -- General Characteristics of Cancer Cells -- Tumor Factors that May Influence Drug Response -- Mechanisms of Drug Resistance -- Host Factors that Influence Response -- Timing of Chemotherapy -- Monitoring Tumor Response -- Clinical Trial Design -- Drug Toxicity -- Emerging Concepts in Cancer Chemotherapy -- Tumor Growth Theory -- Pharmacokinetic and Tumor Heterogeneity -- Dose-Dense Scheduling -- Intraperitoneal (IP) Drug Administration -- Chemotherapeutic Agents (Cytotoxic) -- Alkylating Agents (Covalent Binding to DNA) -- Platinum Compounds (DNA Cross-Linking Agents) -- Antitumor Antibiotics (Non-covalent DNA Binding) -- Antimetabolites -- Microtubule Inhibitors -- Topoisomerase Inhibitors -- Cytotoxic Agents with Unclear Mechanisms of Action -- Chemotherapeutic Agents (Targeted Therapy) -- Estrogen/Progesterone Receptor Modulation -- Aromatase Inhibitors -- Antiangiogenesis Agents -- Tyrosine Kinase Inhibitors -- Poly(Adenosine Diphosphate [ADP]-Ribose) Polymerase or PARP Inhibitors -- References -- 2. Radiation Therapy for Gynecologic Malignancies Lara Bonner Millar and Lilie L. Lin -- Introduction -- Radiation Physics -- X-Ray Production -- Photon Interactions with Matter -- Radioactive Decay -- Radiobiology -- Cell Survival Curve -- Fractionation -- Teletherapy -- Endometrial Carcinoma -- Cervical Carcinoma -- Vulvar Carcinoma -- Vaginal Carcinoma -- Intensity-Modulated Radiation Therapy -- Proton Therapy -- Brachytherapy -- Tandem and Ovoid Brachytherapy -- Interstitial Brachytherapy -- Vaginal Intracavitary Treatment -- Low-Dose Rate or High-Dose Rate -- Clinical Outcomes -- Toxicity -- References -- 3. Preinvasive Disease of the Lower Genital Tract Sarah H. Kim.

Introduction -- Human Papillomavirus -- Cervix -- Epidemiology -- Natural History of Cervical Neoplasia -- HPV Vaccines -- Recommendations for Cervical Cytologic Screening -- Cytologic Nomenclature and Interpretation of Cervical Cytology -- Cervical Transformation Zone -- Techniques of Cervical Cytology -- HPV Testing -- Recommendations for Colposcopy -- Treatment for Cervical Intraepithelial Neoplasia -- Vagina and Vulva -- Epidemiology -- Classification -- Diagnosis -- Treatment of Vulvar and Vaginal Intraepithelial Neoplasia -- References -- 4. Vulvar Cancer Raffi Chalian and Christina S. Chu -- Introduction -- Epidemiology -- Presentation -- Squamous Cell Carcinoma -- Pathology and Natural History -- Lymphatic Metastasis -- Staging -- Treatment -- Vulvectomy -- Lymphadenectomy -- Radiation -- Chemotherapy -- Recurrent Disease -- Outcome -- Non-Squamous Vulvar Cancers -- Verrucous Carcinoma -- Basal Cell Carcinoma -- Vulvar Melanoma -- Bartholin's Gland Carcinoma and Adenocarcinoma -- Sarcoma -- Vulvar Paget's Disease -- References -- 5. Vaginal Cancer Rajul Kothari and Peter A. Argenta -- Introduction -- Anatomic Considerations -- Epidemiology -- Presentation/Natural History -- Pathology -- Childhood -- Embryonal rhabdomyosarcoma -- Endodermal sinus tumor -- Adolescence/Young Adult -- Clear cell adenocarcinoma -- Adult -- Squamous cell carcinoma -- Melanoma -- Leiomyosarcoma -- Aggressive angiomyxoma -- Secondary neoplasms -- Other -- Treatment -- Surgery -- Early stage (I and II) -- Advanced stage (III and IV) -- Radiation -- Chemotherapy -- Recurrent Disease -- Complications -- Outcome/Prognosis -- References -- 6. Cervical Cancer Heidi J. Gray -- Introduction -- Epidemiology -- Histology -- Clinical Presentation -- Signs and Symptoms -- Cervical Biopsy Technique -- Staging -- Patterns of Spread -- Staging of Lymph Nodes -- Treatment.

Surgical Approaches -- Microinvasive disease (stage IA1 and IA2) -- Radical hysterectomy -- Fertility-sparing surgical approaches: Radical trachelectomy and cervical conization -- Minimally invasive surgery (laparoscopic- or robotic-assisted) -- Radiation and Chemotherapy -- Primary Radiation with Concurrent Chemotherapy -- Adjuvant Radiation and Concurrent Chemotherapy -- High risk -- Intermediate risk -- Chemotherapy -- Outcome -- Treatment of Recurrent Disease -- Local or Isolated Recurrence -- Distant Recurrence -- Single-agent chemotherapy -- Combination chemotherapy -- Biologic therapy -- Pelvic Exenteration -- References -- 7. Endometrial Cancer Evelyn B. Marsh -- Introduction -- Epidemiology -- Presentation -- Pathology -- Endometrial Hyperplasia -- Adenocarcinoma -- Endometrioid -- Serous -- Clear cell -- Other cell types -- Diagnosis -- Prognostic Factors -- Stage -- Histology -- Myometrial Invasion -- Peritoneal Cytology -- Lymph Node Metastasis -- Adnexal Metastasis -- Treatment -- Surgical Management -- Nodal dissection -- No nodal dissection -- Selective nodal dissection -- Routine nodal dissection -- Laparoscopic surgical management -- Nonsurgical Management -- Radiation Treatment -- Radiation therapy in early-stage disease -- Radiation therapy for advanced-stage disease -- Chemotherapy for advanced-stage disease -- Treatment of Recurrent Disease -- Radiation therapy for recurrent disease -- Chemotherapy for recurrent disease -- Single agent chemotherapy -- Combination chemotherapy -- Endocrine therapy for recurrent disease -- References -- 8. Uterine Sarcoma Andrea R. Hagemann -- Introduction -- Classification and Terminology -- Clinical Manifestations and Diagnostic Workup -- Smooth Muscle Tumors: Stump and Leiomyosarcoma -- Smooth Muscle Tumor of Uncertain Malignant Potential -- Histopathology -- Diagnosis and treatment.

Recurrence -- Prognosis -- Leiomyosarcoma -- Epidemiology -- Histopathology -- Diagnosis and treatment -- Prognosis -- Recurrence -- Endometrial Stromal Tumors -- Endometrial Stromal Nodule -- Endometrial Stromal Sarcoma -- Epidemiology -- Histopathology -- Diagnosis -- Treatment -- Prognosis -- Recurrence -- Undifferentiated Stromal Sarcoma -- Histopathology -- Treatment -- Prognosis -- Adenosarcoma -- Histopathology -- Diagnosis and Treatment -- Prognosis -- Carcinosarcoma -- Epidemiology -- Histopathology -- Diagnosis and Treatment -- Prognosis -- Recurrence -- References -- 9. Epithelial Ovarian and Fallopian Tube Carcinoma Sarah Czok and Stephanie V. Blank -- Introduction -- Epidemiology -- Demographics -- Risk Factors -- Hereditary Ovarian Cancer -- BRCA1/2 Genes -- Risk-reducing salpingo-oophorectomy -- Lynch Syndrome -- Histology -- Diagnosis -- Symptoms -- Imaging -- CA-125 -- Tissue Diagnosis -- Staging -- Treatment -- Surgery -- Early-stage disease -- Advanced disease -- Chemotherapy -- Adjuvant chemotherapy -- Neoadjuvant chemotherapy -- Targeted/novel therapies -- Follow-up -- Surveillance -- Consolidation Chemotherapy -- Role of Second-look Surgery -- Treatment of Recurrent Disease -- Secondary Cytoreduction -- Second-Line Chemotherapy -- Platinum sensitivity -- Other FDA-approved agents -- Other agents -- Natural History -- References -- 10. Sex Cord-Stromal and Germ Cell Tumors of the Ovary John B. Liao -- Introduction -- Germ Cell Tumors -- Epidemiology -- Presentation -- Histology -- Treatment -- Surgery -- Chemotherapy -- Outcome -- Sex Cord-Stromal Tumors -- Epidemiology -- Presentation -- Histology -- Treatment -- Surgery -- Chemotherapy -- Outcome -- References -- 11. Gestational Trophoblastic Disease and Molar Pregnancy Janos L. Tanyi -- Introduction -- Hydatidiform Mole -- Epidemiology -- Complete Mole -- Partial Mole.

Diagnosis -- Treatment -- Surgical treatment -- Prophylactic chemotherapy -- Follow-up -- Gestational Trophoblastic Neoplasia -- Epidemiology -- Diagnosis -- Classification -- Nonmetastatic disease -- Metastatic disease and choriocarcinoma -- Staging -- Prognostic Indicators -- Treatment -- Treatment of patients with stage I disease -- Treatment of patients with stage II and III disease -- Treatment of patients with stage IV disease -- Future Fertility -- References -- 12. Oncologic Emergencies Sarah Adams -- Introduction -- Hemorrhage -- Cervical Cancer -- Uterine Cancer -- Vulvar Cancer -- Intraoperative Bleeding -- Postoperative Bleeding -- Transfusion Reactions -- Gastrointestinal Complications -- Bowel Obstruction -- Bowel Perforation -- Gastrointestinal Fistulas -- Thromboembolism -- Infectious Complications and Sepsis -- Surgical Wound Infections -- Cellulitis -- Vaginal cuff cellulitis -- Necrotizing fasciitis -- Evisceration or vaginal cuff dehiscence -- Indwelling Catheters or Drains -- Urosepsis -- Gastrointestinal Infections -- Neutropenic Fever -- Tumor Fever -- Summary -- References -- 13. Supportive Care Yevgeniya J. Ioffe and Premal H. Thaker -- Introduction -- Management of Common Symptoms -- Nausea and Vomiting -- Chemotherapy-induced nausea and emesis -- Fatigue -- Constipation -- Management of Complications of Chemotherapy -- Neutropenic Fever -- Growth Factors -- Palmar-Plantar Erythrodysesthesia -- Neurotoxicity -- Mucositis -- Management of Ascites and Pleural Effusions -- Ascites -- Pleural Effusions and Dyspnea -- Management of Chronic Bowel Obstruction -- Medical Management -- Surgical Management -- Management of Pain Syndromes -- Palliative Care -- Cachexia and Malnutrition -- Spirituality -- Conclusion -- References -- Index.