Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring : A Comprehensive Guide.
Title:
Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring : A Comprehensive Guide.
Author:
Dasgupta, Amitava.
ISBN:
9781118347836
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (467 pages)
Contents:
Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring -- Contents -- Preface -- Chapter 1: An Introduction to Tests Performed in Toxicology Laboratories -- Chapter 2: Challenges in Drugs of Abuse Testing -- Chapter 3: False-Positive Results Using Immunoassays for Drugs of Abuse Testing -- Chapter 4: True-Positive Drugs of Abuse Test Results Due to Use of Prescriptions and Nonprescription Drugs -- Chapter 5: When Toxicology Report Is Negative in a Suspected Overdosed Patient: The World of Designer Drugs -- Chapter 6: Abuse of Magic Mushrooms, Peyote Cactus, Khat, and Solvents: No Readily Available Laboratory Tests -- Chapter 7: Limitations of Blood Alcohol Measurements Using Automated Analyzers and Breath Analyzers -- Chapter 8: Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol -- Chapter 9: Poisoning with Warfarin and Superwarfarin: What Can Laboratory Testing Do? -- Chapter 10: Plant Poisoning and the Clinical Laboratory -- Chapter 11: Sources of Erroneous Results in Therapeutic Drug Monitoring Due to Preanalytical Errors, High Bilirubin, Hemolysis, and Lipids -- Chapter 12: Challenges in Therapeutic Drug Monitoring of Digoxin Using Immunoassays -- Chapter 13: Interference in Immunoassays Used for Monitoring Anticonvulsants and the Usefulness of Monitoring Free Anticonvulsants -- Chapter 14: Interference in Immunoassays Used to Monitor Tricyclic Antidepressants -- Chapter 15: Therapeutic Drug Monitoring of Immunosuppressants: Limitations of Immunoassays and the Need for Chromatographic Methods -- Chapter 16: Effect of Drug-Herb Interactions on Therapeutic Drug Monitoring -- Chapter 17: Pharmacogenomics and the Toxicology Laboratory -- Chapter 18: Approaches for Eliminating Interference/Discordant Specimens in Therapeutic Drug Monitoring and Drugs of Abuse Testing -- Index.
Abstract:
The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: False positive results in immunoassays for drugs in abuse testing Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin False positive alcohol tests using breath analyzers and automated analyzers When a toxicology report is negative in a suspected overdose patient: the world of designer drugs Effects of drug-herb interactions on therapeutic drug monitoring Pharmacogenomics and the general principles of genetic analysis Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical
pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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