Extended-Nanofluidic Systems For Chemistry and Biotechnology.
Title:
Extended-Nanofluidic Systems For Chemistry and Biotechnology.
Author:
Mawatari, Kazuma.
ISBN:
9781848168022
Personal Author:
Physical Description:
1 online resource (187 pages)
Contents:
CONTENTS -- Chapter 1. Introduction -- References -- Chapter 2. Microchemical Systems -- References -- Chapter 3. Fundamental Technology: Nanofabrication Methods -- 3.1. Top-Down Fabrication -- 3.1.1. Introduction -- 3.1.2. Bulk nanomachining techniques -- 3.1.2.1. Combination of lithography and wet etching -- 3.1.2.2. Combination of lithography and dry etching -- 3.1.2.3. Other lithographic techniques -- 3.1.2.4. Direct nanofabrication -- 3.1.3. Surface machining techniques -- 3.1.3.1. Utilization of polysilicon as a sacrificial material -- 3.1.3.2. Utilization of metals and polymers as sacrificial materials -- 3.1.4. Imprinting and embossing nanofabrication techniques -- 3.1.5. New strategies of nanofabrication -- 3.1.5.1. Non-lithographic techniques -- 3.1.5.2. Hybrid-material techniques -- 3.1.6. Combination of lift-off and lithography -- 3.2. Local Surface Modification -- 3.2.1. Modification using VUV -- 3.2.2. Modification using an electron beam -- 3.2.3. Modification using photochemical reaction -- 3.3. Bonding -- 3.3.1. Introduction -- 3.3.2. Wafer bond characterization methods -- 3.3.3. Wafer direct bonding -- 3.3.4. Wafer direct bonding mechanism -- 3.3.5. Surface requirements for wafer direct bonding -- 3.3.6. Low temperature direct bonding by surface plasma activation -- 3.3.7. Anodic bonding -- References -- Chapter 4. Fundamental Technology: Fluidic Control Methods -- 4.1. Basic Theory -- 4.2. Pressure-Driven Flow -- 4.3. Shear-Driven Flow -- 4.4. Electrokinetically-Driven Flow -- 4.5. Conclusion and Outlook -- References -- Chapter 5. Fundamental Technology: Detection Methods -- 5.1. Single Molecule Detection Methods -- 5.1.1. Optical detection methods -- 5.1.2. Electrochemical methods -- 5.2. Measurement of Fluidic Properties -- 5.2.1. Nonintrusive flow measurement techniques.
5.2.1.1. Streaming potential/current measurement in pressure-driven flows -- 5.2.1.2. Current monitoring in electroosmotic flow -- 5.2.2. Optical flow imaging techniques using a tracer -- 5.2.2.1. Properties of flow tracers -- 5.2.2.2. Scalar image velocimetry -- 5.2.2.3. Nanoparticle image velocimetry -- 5.2.2.4. Laser-induced fluorescence photobleaching anemometer with stimulated emission depletion -- References -- Chapter 6. Basic Nanoscience -- 6.1. Liquid Properties -- 6.1.1. Introduction -- 6.1.2. Viscosities of liquids confined in extended nanospaces -- 6.1.3. Electrical conductivity in extended nanospaces -- 6.1.4. Streaming current/potential in extended nanospaces -- 6.1.5. Ion transport in extended nanospaces -- 6.1.6. Gas/liquid phase transition phenomena in extended nanospaces -- 6.1.7. Structures and dynamics of liquids confined in extended nanospaces -- 6.2. Chemical Reaction -- 6.2.1. Enzymatic reaction -- 6.2.2. Keto-enol tautomeric equilibrium -- 6.2.3. Nanoparticle synthesis -- 6.2.4. Nano DNA hybridization -- 6.2.5. Nano redox reaction -- 6.3. Liquid Properties in Intercellular Space -- References -- Chapter 7. Application to Chemistry and Biotechnology -- 7.1. Separation -- 7.1.1. Separation by electrophoresis -- 7.1.2. Separation by pressure-driven flow or shear-driven flow -- 7.2. Ion Transport -- 7.3. Concentration -- 7.4. Single Molecule Handling -- 7.4.1. DNA separation -- 7.4.2. Unfolding of DNA -- 7.5. Bioanalysis -- 7.5.1. Immunoassay -- 7.5.2. DNA analysis -- 7.6. Energy Devices -- References -- Chapter 8. Future Prospects -- Index.
Abstract:
For the past decade, new research fields utilizing microfluidics have been formed. General micro-integration methods were proposed, and the supporting fundamental technologies were widely developed. These methodologies have made various applications in the fields of analytical and chemical synthesis, and their superior performances such as rapid, simple, and high efficient processing have been proved. Recently, the space is further downscaling to 101-103nm scale (we call the space extended-nano space). The extended-nano space located between the conventional nanotechnology (100-101nm) and microtechnology (>1?m), and the research tools are not well established. In addition, the extended-nano space is a transient space from single molecules to bulk condensed phase, and fluidics and chemistry are not unknown. For these purposes, basic methodologies were developed, and new specific phenomena in fluidics and chemistry were found. These new phenomena were applied to unique chemical operations such as concentration and ion selection. The new research fields which are now being created are quite different from those in microspace. Unique devices are also increasingly being reported. In this book, we describe the fundamental technologies for extended-nano space and show the unique liquid properties found in this space and applications for single molecule or cell analysis. The research area is very new and hence, exciting. In contrast to other specialized areas, the research fields require wide knowledge (chemistry, fluidics, mechanics, photonics, biology etc.) and state-of-the-art technologies (bottom-up and top-down fabrication for various hard and soft materials, precise fluidic control, single molecule detection methods, and particle surface modification methods etc.), which have not been not covered by conventional review papers or books. Therefore,
researchers or students new to the field need a new book covering these fields including recent research topics, applications and problems to be solved in the future. Our motivation is to summarize the state-of-the-art technologies for research and demonstrate new chemistry and fluidics in extended-nano space for students and researchers in academia or industry. We also emphasize the potential large impact microfluidic technologies have on chemistry and biochemistry.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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