Front Cover -- Liquid Chromatography: Applications -- Copyright -- Contents -- Contributors -- Chapter 1 - Affinity Chromatography -- 1.1. INTRODUCTION -- 1.2. BASIC COMPONENTS OF AFFINITY CHROMATOGRAPHY -- 1.3. BIOAFFINITY CHROMATOGRAPHY -- 1.4. IMMUNOAFFINITY CHROMATOGRAPHY -- 1.5. DYE-LIGAND AND BIOMIMETIC AFFINITY CHROMATOGRAPHY -- 1.6. IMMOBILIZED METAL-ION AFFINITY CHROMATOGRAPHY -- 1.7. ANALYTICAL AFFINITY CHROMATOGRAPHY -- 1.8. MISCELLANEOUS METHODS AND NEWER DEVELOPMENTS -- Acknowledgment -- References -- Chapter 2 - Derivatization in Liquid Chromatography -- 2.1. INTRODUCTION -- 2.2. REAGENT SELECTION -- 2.3. POSTCOLUMN REACTION DETECTORS -- 2.4. CONCLUSIONS -- References -- Chapter 3 - Validation of Liquid Chromatographic Methods -- 3.1. TRADITIONAL METHOD VALIDATION -- 3.2. QUALITY BY DESIGN AND ANALYTICAL METHODS -- 3.3. CONCLUSION -- References -- Chapter 4 - Liquid Chromatographic Separation of Enantiomers -- 4.1. INTRODUCTION -- 4.2. A SHORT HISTORY OF CHIRAL SEPARATIONS BY LIQUID CHROMATOGRAPHY -- 4.3. MATERIALS FOR THE LIQUID CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS -- 4.4. MODES OF LIQUID CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS -- 4.5. SEPARATION OF ENANTIOMERS BY SUPERCRITICAL FLUID CHROMATOGRAPHY -- 4.6. SUMMARY AND FUTURE TRENDS -- References -- Chapter 5 - Liquid Interaction Chromatography of Polymers -- 5.1. INTRODUCTION -- 5.2. THEORETICAL ASPECTS OF ISOCRATIC LIQUID CHROMATOGRAPHY OF POLYMERS -- 5.3. APPLICATIONS OF LIQUID CHROMATOGRAPHY OF POLYMERS -- 5.4. HYPHENATED TECHNIQUES -- 5.5. SUMMARY -- References -- Chapter 6 - Amino Acid and Bioamine Separations -- 6.1. INTRODUCTION -- 6.2. DIRECT SEPARATION OF AMINO ACIDS AND AMINES -- 6.3. INDIRECT SEPARATION OF AMINO ACIDS AND AMINES -- 6.4. ENANTIOSELECTIVE LIQUID CHROMATOGRAPHIC ANALYSIS OF AMINO ACIDS -- 6.5. CONCLUSIONS -- References.

Chapter 7 - Protein and Peptide Separations -- 7.1. INTRODUCTION -- 7.2. METHODS OF PROTEIN LIQUID CHROMATOGRAPHY -- 7.3. CONCLUSIONS -- Acknowledgments -- References -- Chapter 8 - Glycans and Monosaccharides -- 8.1. INTRODUCTION -- 8.2. TYPES OF GLYCANS -- 8.3. ANALYSIS AND CHARACTERIZATION OF GLYCANS -- 8.4. MONOSACCHARIDE COMPOSITION ANALYSIS -- 8.5. CONCLUSIONS -- References -- Chapter 9 - Separation of Lipids -- 9.1. INTRODUCTION AND CONTENTS -- 9.2. DEFINITIONS AND CLASSIFICATION -- 9.3. STRUCTURES AND OCCURRENCE -- 9.4. SAMPLE EXTRACTION AND HANDLING -- 9.5. LIPID ANALYSIS BY LIQUID CHROMATOGRAPHY -- 9.6. CONCLUSIONS AND FUTURE PERSPECTIVES -- References -- Chapter 10 - Forensic Toxicology -- 10.1. GENERAL DRUG SCREENING -- 10.2. LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY IN FORENSIC TOXICOLOGY -- 10.3. TESTING FOR DRIVING UNDER THE INFLUENCE OF DRUGS USING ORAL FLUID -- 10.4. TOXICOLOGICAL ANALYSIS OF HAIR IN THE INVESTIGATION OF DRUG FACILITATED CRIMES -- 10.5. TARGETED POISONS -- 10.6. CONCLUSIONS -- References -- Chapter 11 - Compositional Analysis of Foods -- 11.1. INTRODUCTION -- 11.2. CARBOHYDRATES -- 11.3. VITAMINS -- 11.4. AMINO ACIDS, PEPTIDES, AND PROTEINS -- 11.5. LIPIDS -- 11.6. MINOR COMPONENTS OF FOOD -- 11.7. FOOD ADDITIVES -- 11.8. CONCLUSIONS AND FUTURE TRENDS -- Acknowledgment -- References -- Chapter 12 - Multiresidue Methods for Pesticides and Related Contaminants in Food -- 12.1. INTRODUCTION -- 12.2. SAMPLE TREATMENT -- 12.3. MATRIX EFFECTS IN LC-MS ANALYSIS -- 12.4. METHOD VALIDATION -- 12.5. ANALYSIS OF SAMPLES -- 12.6. INDIVIDUAL METHODS FOR SPECIFIC COMPOUNDS -- 12.7. LC-TOF MS IN THE FIELD OF PESTICIDE RESIDUE ANALYSIS -- References -- Chapter 13 - Environmental Analysis: Persistent Organic Pollutants∗∗Contribution of the U. S. Government. Not subject to co ... -- 13.1. POLYCYCLIC AROMATIC HYDROCARBONS.

13.2. CHLORINATED AROMATIC COMPOUNDS -- 13.3. PESTICIDES -- 13.4. BROMINATED FLAME RETARDANTS -- 13.5. PERFLUOROALKYL COMPOUNDS -- 13.6. REFERENCE MATERIALS -- 13.7. CONCLUDING REMARKS -- 13.8. DISCLAIMER -- References -- Chapter 14 - Environmental Analysis: Emerging Pollutants -- 14.1. INTRODUCTION -- 14.2. GENERAL TRENDS -- 14.3. TARGET ANALYSIS OF SPECIFIC CONTAMINANT GROUPS USING LC-MS -- 14.4. CONCLUSIONS -- References -- Chapter 15 - Analysis of Natural Toxins -- 15.1. INTRODUCTION -- 15.2. TETRODOTOXIN -- 15.3. LIPOPHILIC MARINE TOXINS -- 15.4. SAXITOXIN AND ANALOGS -- References -- Chapter 16 - Liquid Chromatography in the Pharmaceutical Industry -- 16.1. THE ROLE OF SEPARATION SCIENCE IN PHARMACEUTICAL DRUG DEVELOPMENT -- 16.2. INCREASING CHROMATOGRAPHIC RESOLUTION -- 16.3. CHROMATOGRAPHIC METHOD DEVELOPMENT: RPLC -- Acknowledgments -- References -- Chapter 17 - Determination of Veterinary Drug Residues in Foods by Liquid Chromatography-Mass Spectrometry: Basic and Cutti ... -- 17.1. INTRODUCTION -- 17.2. OPTIONS IN VETERINARY RESIDUE ANALYSIS USING LC-MS -- 17.3. CONCLUSIONS -- References -- Chapter 18 - Analysis of Vitamins by Liquid Chromatography -- 18.1. INTRODUCTION -- 18.2. LIQUID CHROMATOGRAPHIC DETERMINATION OF WATER-SOLUBLE VITAMINS -- 18.3. LIQUID CHROMATOGRAPHIC DETERMINATION OF FAT-SOLUBLE VITAMINS -- 18.4. MULTIVITAMIN METHODS -- References -- Chapter 19 - Applications of Liquid Chromatography in the Quality Control of Traditional Chinese Medicines, an Overview -- 19.1. INTRODUCTION -- 19.2. LIQUID CHROMATOGRAPHIC ANALYSIS OF TRADITIONAL CHINESE MEDICINES -- 19.3. CONCLUSIONS -- Acknowledgments -- References -- Chapter 20 - Analysis of Neurotransmitters and Their Metabolites by Liquid Chromatography -- 20.1. INTRODUCTION -- 20.2. BIOGENIC AMINES -- 20.3. ACETYLCHOLINE -- 20.4. AMINO ACIDS.

20.5. PURINES: ADENOSINE TRIPHOSPHATE AND ADENOSINE -- 20.6. ENDOCANNABINOIDS -- 20.7. NEUROPEPTIDES -- 20.8. MULTIANALYTE MONITORING OF NEUROTRANSMITTERS FROM DIVERSE CLASSES -- 20.9. CLINICAL APPLICATIONS OF MICRODIALYSIS SAMPLING AND LIQUID CHROMATOGRAPHIC-BASED ANALYSIS -- 20.10. CONCLUSIONS -- References -- Chapter 21 - Clinical Chemistry, Including Therapeutic Drug Monitoring and Biomarkers for Diagnosis -- 21.1. INTRODUCTION -- 21.2. PREANALYTICAL SPECIMEN HANDLING IN CLINICAL LIQUID CHROMATOGRAPHY -- 21.3. SEPARATION TECHNOLOGIES IN CLINICAL LIQUID CHROMATOGRAPHY -- 21.4. DETECTION TECHNOLOGIES IN CLINICAL LIQUID CHROMATOGRAPHY -- 21.5. APPLICATIONS -- 21.6. CONCLUSION -- References -- Chapter 22 - Speciation and Element-Specific Detection -- 22.1. INTRODUCTION -- 22.2. SAMPLING -- 22.3. SAMPLE STORAGE AND PROCESSING -- 22.4. SPECIATION APPROACHES: DIRECT METHODS OR HYPHENATED TECHNIQUES -- 22.5. INTERFACING: NEBULIZERS, USE OF INTERNAL STANDARD AND POSTCOLUMN DILUTION -- 22.6. ELEMENT-SELECTIVE DETECTION -- 22.7. QUANTIFICATION AND QUALITY CONTROL -- References -- Index.