Cover image for Reverse Genetics of RNA Viruses : Applications and Perspectives.
Reverse Genetics of RNA Viruses : Applications and Perspectives.
Title:
Reverse Genetics of RNA Viruses : Applications and Perspectives.
Author:
Bridgen, Anne.
ISBN:
9781118405345
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (418 pages)
Contents:
1 Introduction -- Part I Positive sense RNA viruses -- 2 Coronavirus reverse genetics -- 3 Reverse genetic tools to study hepatitis C virus -- 4 Calicivirus reverse genetics -- Part II Negative sense RNA viruses -- 5 Reverse genetics of rhabdoviruses -- 6 Modification of measles virus and application to pathogenesis studies -- 7 Bunyavirus reverse genetics and applications to studying interactions with host cells -- 8 Using reverse genetics to improve influenza vaccines -- Part III Double-Stranded RNA viruses -- 9 Bluetongue virus reverse genetics -- 10 Genetic modification in mammalian orthoreoviruses -- Part IV Recent and future developments -- 11 Reverse genetics and quasispecies -- 12 Summary and perspectives -- Index.
Abstract:
Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea  and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups.  Written by a team of international experts, including some of the leading researchers in the field.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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