Bio-Nanomaterials: Designing materials inspired by nature -- Contents -- Preface -- 1 Molecular Units -- 1.1 Case Studies -- 1.1.1 Nucleic Acids -- 1.1.2 Proteins -- 1.1.3 Carbohydrates -- 1.1.4 Lipids -- 1.2 Basic Principles -- 1.2.1 The Persistence Lengths of Biopolymer Chains -- 1.2.2 Equilibrium Shape of a Semiflexible Polymer Chain -- 1.2.3 The Load-Extension Diagram of a Semiflexible Polymer Chain -- 1.2.4 Cooperativity -- 1.2.5 Protein Folding -- 1.2.6 DNA Melting Transition -- 1.2.7 Biocatalytic Reactions -- 1.3 Bioengineering -- 1.3.1 Biointerfacing -- 1.3.2 DNA-Based Nanotechnology -- 1.3.2.1 Biomolecular Templates for Submicrometer Electronic Circuitries -- 1.3.2.2 DNA-Based Nanoprobes -- 1.3.3 Protein-Based Nanotechnology -- References -- 2 Molecular Recognition -- 2.1 Case Study -- 2.2 Basic Principles -- 2.2.1 Complementary Interaction between Proteins and Ligands -- 2.2.2 Cooperative Protein-Ligand Interaction -- 2.2.3 The Enzyme-Linked Immunosorbent Assay -- 2.3 Engineering of Biomolecular Recognition Systems -- 2.3.1 Engineering of Protein-Based Bioaffine Materials -- 2.3.1.1 Interfacing Mechanisms of Proteins via Bioaffinity -- 2.3.2 Engineering of Sensing Biofunctionalized Materials -- 2.3.2.1 Design Principles of Biosensors -- 2.3.2.2 Integration of Sensing Biological Elements and Transducer Units -- References -- 3 Cell Adhesion -- 3.1 Case Study -- 3.2 Basic Principles -- 3.2.1 The Cellular Mechanotransduction System -- 3.2.2 Mechanical Impact of the ECM on Cell Development -- 3.2.3 Influence of the Microenvironment Topology on the Cell Spreading and Development -- 3.3 Bioengineering -- 3.3.1 The Basic Approach and Goals -- 3.3.2 Tailored Surfaces for In Vitro Culturing of Cells -- 3.3.2.1 A Modular Polymer Platform for Mechanically Regulated Cell Culturing at Interfaces.

3.3.2.2 Regulation of Cell Fate by Nanostructured Surfaces -- 3.3.3 Three-Dimensional Scaffolds for Tissue Engineering -- 3.3.4 Switchable Substrates and Matrices -- References -- 4 Whole-Cell Sensor Structures -- 4.1 Case Studies -- 4.2 Basic Principles -- 4.3 Bioengineering -- References -- 5 Biohybrid Silica-Based Materials -- 5.1 Case Studies -- 5.2 Basic Principles -- 5.2.1 Preparation of Silica-Based Xerogels -- 5.2.2 Biological Properties of Silica-Based Biocers -- 5.3 Bioengineering -- 5.3.1 Bioactive Sol-Gel Coatings and Composites -- 5.3.2 Biocatalytic Sol-Gel Coatings -- 5.3.3 Bioremediation -- 5.3.4 Cell-Based Bioreactors -- 5.3.5 Silica-Based Controlled Release Structures -- 5.3.6 Patterned Structures -- 5.4 Silicified Geological Biomaterials -- References -- 6 Biomineralization -- 6.1 Case Studies -- 6.2 Basic Principles -- 6.2.1 Precipitation -- 6.2.1.1 Thermodynamics of Mineralization -- 6.2.1.2 Kinetics of Mineralization -- 6.2.2 Phenomenology of Biomineralization -- 6.2.3 Basic Mechanisms in Biomineralization -- 6.2.4 Biologically Mediated Mineralization: the Competition between Inhibition and Growth -- 6.2.4.1 Effect of Polypeptides on Precipitate Habitus -- 6.2.4.2 The Formation of Metastable Polymorphs -- 6.2.5 Biologically Induced Mineralization: Role of the Epicellular Space and the Extracellular Polymeric Substances -- 6.2.6 Biologically Controlled Mineralization: Molecular Preorganization, Recognition, and Vectorial Growth -- 6.2.6.1 Intracellular Mineralization -- 6.2.6.2 Epi- and Extracellular Mineralization -- 6.2.7 Mineralization of Diatom Shells: an Example of Unicellular Hierarchical Structures -- 6.2.8 Mineralization of Bone: an Example of Multicellular Biomineralization -- 6.2.8.1 The Mesoscopic Architecture of Bone -- 6.2.8.2 Bone Remodeling and Bone Repair.

6.2.8.3 The Nanoscopic Structure of the Extracelluar Matrix of Bone -- 6.2.8.4 The Polymer-Induced Liquid Precursor Process -- 6.2.8.5 Scale-Dependent Mechanical Behavior of Bone -- 6.2.9 Ancient Evidence of Biomineralization -- 6.2.9.1 Stromatolites: the Oldest Fossils by Biogenic Mineralization -- 6.3 Bioengineering -- 6.3.1 Bacteria-Derived Materials Development -- 6.3.1.1 Bio-Palladium: Biologically Controlled Growth of Metallic Nanoparticles -- 6.3.1.2 Biogenic Ion Exchange Materials -- 6.3.2 Bio-Inspired Design of Mineralized Collagen and Bone-Like Materials -- 6.3.2.1 Biomimetic Growth of Apatite-Gelatin Nanocomposites -- 6.3.2.2 Biomimetic Manufacturing of Mineralized Collagen Scaffolds -- 6.3.3 Biomimicking of Bone Tissue -- 6.3.3.1 Natural versus Synthetic Biopolymers for Scaffold Design -- 6.3.3.2 Protein-Engineered Synthetic Polymers -- 6.3.3.3 Protein-Engineered Collagen Matrices -- 6.3.4 Microbial Carbonate Precipitation in Construction Materials -- 6.3.5 The Potential of Biomineralization for Carbon Capture and Storage (CCS) -- References -- 7 Self-Assembly -- 7.1 Case Study -- 7.2 Basic Principles -- 7.2.1 Basic Phenomena of Self-Assembly and Self-Organization -- 7.2.2 Self-Assembly of Protein Filaments: the Cytoskeleton -- 7.2.3 Self-Assembly of β-Sheets: the Amyloid Fibrils -- 7.2.4 Self-Assembly of Two-Dimensional Protein Lattices: the Bacterial Surface Layers (S-Layers) -- 7.2.5 Self-Organized Structures of Lipids -- 7.2.6 Liquid Crystals -- 7.3 Bioengineering -- 7.3.1 In Vitro Self-Assembly of Large-Scale Nanostructured Biomaterials -- 7.3.2 Template-Directed Assembly of Artificial Nanoparticles and Nanowires -- 7.3.3 Template-Free Directed Self-Assembly of Nanoparticles -- References -- Appendix A: Constants, Units, and Magnitudes -- A.1 Fundamental Constants -- A.2 Table of SI Base Units -- A.3 Table of Derived Units.

A.4 Magnitudes -- A.4.1 Sizes -- A.4.2 Energies -- A.4.3 Rates and Diffusion Constants -- Appendix B: Energy of a Bent Fiber -- Appendix C: Circular Dichroism Spectroscopy -- Appendix D: Task Solutions -- Index.