
Male-mediated Developmental Toxicity.
Title:
Male-mediated Developmental Toxicity.
Author:
Aitken, R John.
ISBN:
9781847557643
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (317 pages)
Series:
Issues in Toxicology ; v.2
Issues in Toxicology
Contents:
Male-mediated Developmental Toxicology -- Contents -- Foreword -- Introductory Scientific Presentations -- CHAPTER 1 Epigenetic Transgenerational Actions of Endocrine Disruptors through the Male Germ-Line -- 1.1 Review -- Acknowledgments -- References -- Heritable Effects in Humans -- CHAPTER 2 Reproductive Outcomes among Men Treated for Cancer -- 2.1 Why Study Cancer Survivors? -- 2.2 Endpoints -- 2.3 Decreased Fertility -- 2.4 The Five-Center Study -- 2.4.1 Design -- 2.4.2 Results -- 2.4.3 The Male Experience -- 2.5 The Childhood Cancer Survivor Study -- 2.5.1 Design -- 2.5.2 Results -- 2.6 Future Directions -- 2.7 Counseling -- References -- CHAPTER 3 Cancer in Siblings of Children with Cancer in the Nordic Countries: A Population-Based Cohort Study Paediatric Cancer: An Indicator of Familial Cancer Risk? -- 3.1 Epidemiological Research in the Nordic Countries -- 3.1.1 Unique Personal Identification Numbers -- 3.1.2 Danish Health Registries: Valuable Tools in MedicalResearch -- 3.1.3 The Danish Cancer Registry -- 3.2 Role of Dominant and Recessive Conditions in Cancer Causation -- 3.3 Cancer in Siblings of Children with Cancer in the Nordic Countries: A Population-Based Cohort Study -- 3.3.1 Patients, Procedures and Analyses -- 3.3.2 Results -- 3.4 Cancer in Parents of Children with Cancer in Denmark -- 3.5 Cancer in Off spring of Cancer Survivors: A Population-Based Cohort Study in the Nordic Countries -- 3.6 Paediatric Cancer: An Indicator of Familial Cancer Risk? -- References -- CHAPTER 4 What Harms the Developing Male Reproductive System? -- 4.1 Introduction -- 4.2 Descriptive Epidemiology of Conditions Affectingthe Male Reproductive System -- 4.2.1 Semen Quality and Fertility -- 4.2.2 Testicular Cancer -- 4.2.3 Anomalies of the Male Genitalia -- 4.2.4 The Question of Linkage -- 4.3 Can Endocrine Disruption Explain these Observations?.
4.3.1 Oestrogens -- 4.3.2 Anti-androgens -- 4.3.3 The Expected Spectrum of Effects -- 4.3.4 Interpretation -- 4.4 Genetic Epidemiology -- 4.4.1 Semen Quality and Fertility -- 4.4.2 Testicular Cancer -- 4.4.3 Anomalies of the Male Genitalia -- 4.5 Can Genetic Damage Explain these Observations? -- 4.5.1 Can Genetic Disorders Increase Rapidly Over Time? -- 4.5.2 Is Heritable Infertility Possible? -- 4.5.3 So What is Going on? -- 4.6 Conclusions -- References -- CHAPTER 5 Links between Paternal Smoking and Childhood Cancer -- 5.1 Introduction -- 5.2 The Oxford Survey of Childhood Cancers -- 5.2.1 OSCC Data: 1977-1981 -- 5.2.2 OSCC Data: 1953-1955 -- 5.2.3 OSCC Data: 1971-1976 -- 5.3 Inter Regional Epidemiological Survey of Childhood Cancers -- 5.4 Other Studies -- 5.5 Discussion -- Acknowledgments -- References -- CHAPTER 6 Feasibility Study of Metal Effects on the X:Y Ratio in Human Sperm -- 6.1 Introduction -- 6.2 Research Methods -- 6.3 Findings -- 6.4 Discussion -- 6.5 Conclusion -- Acknowledgments -- References -- CHAPTER 7 Use of the Sperm Chromatin Structure Assay (SCSAs) as a Diagnostic Tool in the Human Infertility Clinic -- 7.1 Introduction -- 7.2 Materials and Methods -- 7.3 SCSA Data and Clinical Results -- 7.4 Conclusions -- References -- CHAPTER 8 Safety of Sperm for Use in Intra-Cytoplasmic Sperm Injection -- 8.1 Introduction -- 8.2 Incidence of Sperm Chromosome Aneuploidy and Implications on Reproduction -- 8.3 Epigenetic Effects and Their Relation to Intra-Cytoplasmic Sperm Injection -- 8.4 The Impact of Sperm Nuclear DNA Strand Breakson Reproductive Outcome -- 8.5 Improving the Safety of Intra-Cytoplasmic Sperm Injection -- 8.6 Conclusion -- References -- Animal Models.
CHAPTER 9 Male-Mediated F1 Effects in Mice Exposed to Di(2-ethylhexyl)phthalate (DEHP) -- 9.1 Introduction -- 9.2 Methods -- 9.2.1 Effects in Exposed Generation -- 9.2.2 Effects in the Offspring of Exposed Males -- 9.2.3 Statistical Analysis -- 9.3 Results -- 9.4 Discussion -- Acknowledgments -- References -- CHAPTER 10 Prevention of Adverse Effects of Cancer Treatment on the Germline -- 10.1 Infertility Resulting from Cancer Treatment -- 10.2 Block to Spermatogonial Differentiation -- 10.3 Approaches to Prevention of Adverse Effects on the Germline -- 10.4 Protection or Stimulation of Spermatogenic Recovery by Hormonal Suppression -- 10.5 Mechanisms of Hormonal Stimulation of Spermatogenic Recovery in Rat -- 10.6 Potential for Clinical Application -- 10.7 Application in Conjunction with Spermatogonial Transplantation -- Acknowledgments -- References -- CHAPTER 11 Molecular Changes in Spermand Early Embryos after Paternal Exposure to a Chemotherapeutic Agent -- 11.1 Introduction -- 11.2 Cyclophosphamide Induces a Stage-Specific Response in Male Germ Cells -- 11.2.1 Altered Gene Expression during Spermatogenesis -- 11.2.2 Increased Chromosomal Aberrations -- 11.2.3 Effects on Cell-Cycle Progression -- 11.2.4 Disturbances in Chromatin Structure -- 11.3 Paternal Cyclophosphamide Exposure Disrupts Programming in the Early Embryo -- Acknowledgments -- References -- CHAPTER 12 Transmissible Genetic Risk Causing Tumours in Mice and Humans -- 12.1 Introduction -- 12.2 Experimental Evidences -- 12.2.1 Embryonic Deaths and Malformations -- 12.2.2 Induction of Tumours in the Offspring -- 12.2.3 Possible Mechanism and Molecular Studies -- 12.3 Relevant Human Studies -- 12.4 Summary -- Acknowledgments -- References.
CHAPTER 13 Heritable Effects on DNA Damage Following Paternal F0 Germline Irradiation -- 13.1 Introduction -- 13.2 Materials and Methods -- 13.2.1 Animals -- 13.2.2 Irradiation and Dosimetry -- 13.2.3 Sample Collection -- 13.2.4 Assessment of Sperm Motility and Morphology -- 13.2.5 Testicular and Epididymal Sperm Counts -- 13.2.6 Sperm Comet Assay -- 13.2.7 Statistical Analyses -- 13.3 Results -- 13.3.1 F0 Males -- 13.3.2 Breeding Results for Acutely Irradiated F0 Males -- 13.3.3 F2 Generation Male Offspring -- 13.3.4 F3 Generation Male Offspring -- 13.4 Discussion -- 13.4.1 Overview -- 13.4.2 Delayed Effects of Acute Spermatogonial Irradiation onSperm from F0 Male Mice -- 13.4.3 Selection vs. Genome Modification -- 13.4.4 Heritable Effects of Paternal F0 Irradiation on F2 and F3Generation Sperm -- 13.5 Conclusion -- Acknowledgments -- References -- CHAPTER 14 Influence of DNA Methylationand Genomic Imprinting in the Male Germ Line on Pregnancy Outcome -- 14.1 Introduction -- 14.2 DNA Methylation and DNA Methyltransferases:Roles and Importance -- 14.3 Acquisition of DNA Methylation Patterns During Spermatogenesis -- 14.4 DNA Methyltransferase Enzymes and their Regulation in the Male Germ Line -- 14.5 Perturbing DNA Methylation in the MaleGermline: Consequences for the Progeny -- 14.5.1 DNA Methyltransferase Deficiency -- 14.5.2 Cytidine Analogues -- 14.5.3 Folate Pathway Enzymes -- 14.6 Conclusions and Implications -- Acknowledgments -- References.
CHAPTER 15 Information Content of Ejaculate Spermatozoa and its Potential Utility in Toxicologyand Infertility Based Research Programmes -- 15.1 Introduction -- 15.2 Composition of Spermatozoal RNA -- 15.3 Utility of Spermatozoal RNA -- 15.4 Spermatozoal Chromatin -- 15.5 DNA Damage Susceptibility -- 15.6 Transmission of the Paternal Genome -- 15.7 Conclusions -- References -- Germline Mutagenesis -- CHAPTER 16 Origin of Paternal Mutations -- 16.1 Historical -- 16.2 Male Excess and Paternal Age Effect for BaseSubsitutions -- 16.3 Exceptions to the Sex and Paternal Age Effect -- 16.4 Hot Spots -- 16.5 Sperm Analysis -- 16.6 Premeiotic Selection or Sperm Competition -- 16.7 Conclusion -- References -- CHAPTER 17 Redox Regulation of DNA Damage in the Male Germ Line -- 17.1 Introduction -- 17.2 The Central Hypothesis -- 17.3 Causes of DNA Damage in Spermatozoa -- 17.4 Oxidative Stress -- 17.5 Origins of Oxidative Stress -- 17.6 Conclusions -- Acknowledgments -- References -- CHAPTER 18 Advances in the Direct Measurements of Partial Chromosomal Duplication, Deletions and Breaks in Humanand Murine Sperm by Sperm FISH -- 18.1 Introduction -- 18.2 FISH Methods for Detecting Human Sperm Carrying Structural Chromosomal Aberrations -- 18.3 FISH Methods for Detecting Mouse Sperm Carrying Chromosome Structural Aberrations -- 18.4 Mechanisms of Induction of Chromosomal Aberrations Detectable by Sperm FISH -- 18.5 Interspecies Comparison of Baseline Frequencies of Chromosomal Aberrations -- 18.6 Applications of the Novel Sperm FISH Methods for Detecting Sperm Carrying Chromosomal Aberrations -- 18.7 Implications for Future Studies -- Acknowledgments -- References.
CHAPTER 19 Radiation-induced Transgenerational Instability in Mice.
Abstract:
Male germ line mutagenesis and the effects on developmental defects in the next generation.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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