Cover -- Title Page -- Copyright -- Contents -- List of Contributors -- Preface -- Acknowledgements -- Chapter 1 Multidisciplinary Care -- Introduction -- Evidence for MDT working -- Databases -- Cancer waiting times -- Treatment intent -- Staging -- Patient assessments -- What makes an effective MDT -- Further reading -- Chapter 2 Cancer Imaging -- Introduction -- TNM staging -- Plain film -- Fluoroscopy -- Mammography -- Ultrasound -- Computed tomography -- Magnetic resonance imaging -- Nuclear medicine -- Further reading -- Chapter 3 Surgery -- Principles -- Staging -- Preoperative therapy -- Preoperative preparation -- Intraoperative staging -- Operative approach -- Technical developments -- Computer-assisted surgery -- Laparoscopic and robotic minimally invasive surgery -- Margins -- Function and reconstruction -- Emergency surgery -- Further reading -- Chapter 4 Surgery for Metastatic Disease -- Introduction -- Oligometastatic disease -- Surgery for patients with metastases -- Metastases to bone -- Renal cell carcinoma -- Orthopaedic fixation for bone disease -- Fixation of long bones -- Spinal metastases -- Treatment options -- Spinal surgery -- Vertebroplasty and kyphoplasty -- Brain metastases -- Liver metastases -- Lung metastases -- Further reading -- Chapter 5 Chemotherapy -- Introduction -- Treatment settings -- Curative Chemotherapy -- Neoadjuvant/Primary chemotherapy -- Adjuvant chemotherapy -- Palliative chemotherapy -- NHS cancer strategies and chemotherapy -- Administration of chemotherapy -- Oral administration -- IV administration -- Intrathecal (IT) Administration -- Intraperitoneal Administration -- Modes of action of chemotherapy -- Dosing and schedule -- Further reading -- Chapter 6 Toxicities of Chemotherapy -- Introduction -- Hair loss -- Haematological toxicity -- GI toxicity -- Neurological toxicity.

Nausea and vomiting -- Late effects of chemotherapy -- Pulmonary toxicity -- Cardiac toxicity -- Second cancers -- Fertility -- Further reading -- Chapter 7 Radiotherapy -- Introduction -- Treatment practicalities -- Radiobiological principles -- Treatment intent -- Palliative radiotherapy -- Emergency radiotherapy -- Radical radiotherapy -- Intraoperative radiotherapy -- Intensity-modulated radiotherapy and image-guided radiotherapy -- New technologies -- Further reading -- Chapter 8 Toxicities of Radiotherapy -- Introduction -- Radiation sensitivity -- Acute side effects -- Late side effects -- Skin -- Bone marrow suppression -- Fatigue -- Brain -- Head and neck -- Oral mucositis -- Dry mouth (xerostomia) -- Chest -- Oesophagitis -- Pneumonitis -- Breast -- Lymphoedema -- Abdomen -- Vomiting -- Lower abdomen -- Bladder -- Rectum -- Female genital tract -- Further reading -- Chapter 9 Endocrine Therapy -- Breast cancer -- Current endocrine therapy -- Adjuvant endocrine therapy -- Metastatic/advanced disease -- Neoadjuvant setting -- Male breast cancer -- Combination of endocrine and targeted therapy -- Side effects of endocrine therapy -- Prostate cancer -- Drugs targeting testosterone synthesis and signalling -- Indications for endocrine treatment in prostate cancer -- Toxicity of endocrine therapy -- Further reading -- Chapter 10 Biological and Targeted Therapies -- Introduction -- Types of biological therapy -- Monoclonal antibodies -- mABs and delivery of chemotherapy or radiotherapy -- Targeted therapies that regulate events in the nucleus -- Interferon and interleukin -- Vaccines -- Colony stimulating factors -- Toxicities -- The future -- Further reading -- Chapter 11 Trials in Cancer Care -- Introduction -- What are clinical trials? -- The drug development process -- Phases of clinical trials -- Phase I -- Phase II -- Phase III -- Phase IV.

Ethical principles of clinical trials -- Good clinical practice -- Trial design -- Biomarkers in cancer trials -- Biomarker discovery: a historical perspective -- Approaches to the detection of biomarkers: genomics, proteomics, metabolomics -- Further reading -- Chapter 12 Oncological Emergencies -- Acute oncology: the management of oncology emergencies -- Neutropenic sepsis -- Microbiology -- Antimicrobial treatment -- Granulocyte colony stimulating factor -- Metastatic spinal cord compression -- Superior vena cava obstruction -- Hypercalcaemia of malignancy -- Pathophysiology of hypercalcaemia -- Management -- Treatment -- Lymphangitis carcinomatosis -- Anticancer therapies -- Symptom control -- Hypomagnasaemia -- Treatment of hypomagnasaemia -- Further reading -- Chapter 13 Cancer in the Elderly -- The ageing population and cancer -- Challenges in management of older patients with cancer -- Clinical trial data -- Physiological changes in older patients -- Effects of ageing on pharmacokinetics -- Nutritional status -- Social and neuropsychological changes -- Variability in ageing -- Objective assessments: Comprehensive Geriatric Assessment -- Optimising care -- Further reading -- Chapter 14 Nutrition -- Introduction -- Surgery -- Chemotherapy and biological agents -- Radiotherapy -- Nutritional goals -- Poor appetite -- Oral nutritional supplements -- Vitamin and minerals -- Enteral tube feeding -- Parenteral nutrition -- Weight gain -- Further reading -- Chapter 15 Complementary and Alternative Medicine in Cancer Patients -- Background -- Regulation -- Evidence -- Therapies -- Acupuncture -- Massage and manipulation techniques -- Chiropractic -- Aromatherapy -- Homeopathy -- Chinese and herbal medicines -- Spirituality -- The Internet -- Advising cancer patients -- Further reading.

Chapter 16 Specialist Nursing Care -- Introduction -- Emotional support -- Cancer information -- Side effect management -- Sexual health -- Social and financial considerations -- Team liaison and advocacy -- Follow up -- Support outside hospital -- Further reading -- Chapter 17 Cancer Survivorship -- Cancer survival -- Morbidity secondary to cancer treatment -- Chronic effects of cancer treatment -- Gastrointestinal problems -- Bone health -- Sexual dysfunction -- Fertility issues -- Cardiovascular disease -- Secondary malignancies -- Psychological issues -- Employment and finance -- Unmet need -- Survivorship initiatives -- Survivorship courses -- Exercise -- Further reading -- Index.