Cover -- Title page -- Copyright -- Contents -- Series Foreword -- Preface -- Contributors -- 1. Importance of the Multidisciplinary Approach to Colorectal Cancer -- 2. Prevention and Screening -- Risk Factors, Screening, and Chemoprevention -- Epidemiology -- The Biology of CRC -- Screening for CRC -- Screening Recommendations -- Chemoprevention in CRC -- Clinical Evaluations to Date -- The Future of CRC -- Identification of High-Risk Patients: Familial and Environmental Factors -- Family History of CRC Outside of Known Genetic Syndromes -- Risk Conferred by Personal History of Noncolorectal Cancer -- Risk Related to Ethnicity -- Hereditary Syndromes of CRC -- Lynch Syndrome as a Model for Identification of Hereditary High-Risk Patients -- Introduction -- Family Considerations -- LS Characteristics -- Cancer Spectrum in LS -- Management -- Future Research Developments -- Summary -- Colorectal Cancer in Inf Lammatory Bowel Disease -- Risk Factors for CRC in Chronic Colitis -- Dysplasia as a Precursor for Cancer in IBD -- Management of Dysplasia in Flat Mucosa -- Management of Raised Dysplastic Lesions -- References -- 3. Navigation Programs in Colorectal Cancer Care -- Rationale for Colorectal Navigation Services -- Overview of the Role of Navigation as it Supports Multidisciplinary Care Models -- Overview of the Program -- Nurse Navigator Placement-Location, Location, Location! -- Navigation Role in Colorectal Quality Care -- References -- 4. Assessment and Management of Colorectal Polyps and Cancer Precursor Lesions -- Introduction -- Molecular Pathogenesis of CRC -- Precancerous Colorectal Neoplasms -- Screening for Polyps and Precursor Lesions -- Polyp and Precursor Lesion Detection and Removal -- References -- 5. Preoperative Staging: Imaging and Endoscopic Approaches -- Multimodality Imaging of Colorectal Cancer -- Screening.

Local Staging -- Evaluation of Metastatic Disease -- Endoscopic Approaches to Colon Cancer -- Diagnostic Considerations for Colon Cancer: Colonoscopy -- Endoscopic Management of Malignant Colon Polyps and Polyps with High Grade Dysplasia -- Endoscopic Approaches to Rectal Cancer -- References -- 6. Pathology and Molecular Diagnostics -- Pathology of Colon and Rectal Carcinoma -- Pathology of Precursor Lesions and Conditions -- Molecular Pathology of Colon and Rectal Carcinoma -- Clinical-Pathologic Correlations with Molecular Pathways -- Conclusions -- References -- 7. Management of Nonmetastatic Colon Cancer -- Surgical Considerations -- History of Surgery for Colon Cancer -- Epidemiology of Colon Cancer -- The Role of Chemotherapy -- Introduction -- Decrease in Mortality with Adjuvant Chemotherapy -- Unrealized Promise: Failure in the Adjuvant Setting of Other Agents Approved for Stage IV Disease -- Current Open Questions and Areas of Debate in Adjuvant Colon Cancer -- How Much is Enough? the Idea Effort and Evidence for Shorter Duration of Chemotherapy -- Personalized Medicine-Unrealized Promises in adjuvant Colon Cancer -- Markers That are Not prognostic: K-Ras, Mss, and Loh at 18Q -- Elderly Patients -- Conclusions -- References -- 8. Nonmetastatic Rectal Cancer: Early and Locally Advanced -- Radiation Oncology -- Introduction -- Staging and Workup -- Prognostic Factors -- Anatomic Considerations for the Radiation Oncologist -- Early Stage Rectal Cancer: Postoperative Radiationin the Setting of Limited Surgical Resection -- The Role of Adjuvant Radiation and Chemotherapy in Rectal Cancer -- The Role of Neoadjuvant RT in Rectal Cancer -- Neoadjuvant Chemoradiation -- The Role of RT Dose Escalation -- Chemotherapy Optimization -- The Evolving Role of Intraoperative RT (IORL) in the Management of Rectal Cancer -- Future Directions -- References.

9. Management of Synchronous Metastases -- Surgical Considerations in the Treatment of Synchronous Stage IV Disease -- Chemotherapy for the Treatment of Synchronous Stage IV Disease -- The Role of Radiotherapy for Liver Metastases -- Future Directions -- References -- 10. Management of Potentially Resectable Recurrentdisease -- Systemic Therapy Considerations -- Adjuvant Hepatic Arterialinfusion (Hai) of Chemotherapy -- Adjuvant Hai with Systemic chemotherapy -- Neoadjuvant Hai -- Systemic Chemotherapy -- Conclusions -- Liver Metastases: Surgical Considerations -- Pulmonary Metastases: Surgical Considerations -- Pelvic Recurrences: Surgical Considerations -- Introduction -- References -- 11. Systemic Therapy -- First-Line Chemotherapy -- Agents Approved for First-Line Therapy for Metastatic Colon Cancer -- General Principles of the Therapy for MCRC -- Conclusions -- Second- and Third-Line Therapy for MCRC -- Therapy After Progression -- Second-Line Chemotherapy after First-Line Progression -- Bevacizumab in the Nonfirst-Line setting -- Cetuximab and Panitumumab in the Nonfirst -- Dual Antibody Therapy in the Nonfirst -- Novel Agents with Recent FDA Approval -- Conclusions -- References -- 12. Phase I/II Clinical Trials in Metastatic Colorectalcancer -- Introduction -- Overall Design of Phase I Trials -- Early Evidence of Activity -- The Phase I/II Interface -- Future Phase I Trials-What we Should Try to Learn -- References -- 13. Management of Systemic Treatment-Induced Toxicities -- Introduction -- Diarrhea -- Oxaliplatin-Induced Neurotoxicity -- Oxaliplatin-Induced Peripheral Neuropathy -- Epidermal Growth Factorreceptor Inhibitors and CRC -- Hand-Foot Syndrome From Drugs Used in CRC -- References -- 14. Radiation Palliative Care -- Symptom Management of Radiation Palliative Care -- Symptom Management of Rectal Cancer -- Conclusions -- References.

15. Multidisciplinary Approach to Quality of Life -- Health-Related Quality of Life -- Localized Disease (Stages I - III colon and Rectal Cancer) -- Locally Recurrent and Metastatic Disease -- Conclusions -- References -- 16. Racial Disparities in Colorectal Cancer -- Colorectal Surveillance and Screening -- Colorectal Disease Status -- Decreasing Incidence and Mortality -- Prognostic Factors in African Americans -- Molecular and Gene Expression -- Therapies of CRC -- Other Considerations -- Conclusions -- References -- 17. Models of Care Delivery -- Challenges of CRC Care delivery-A Perfect Storm? -- Do Emerging Delivery Models address Challenges? -- Preparing for the Future Cancer delivery Model -- Acknowledgment -- References -- 18. Future Directions: Gene Expression profiling -- Introduction -- Class Discovery in Colon Cancer -- Class Prediction in Colon Cancer -- The Challenge of Heterogeneity -- Integrative Genomics -- References -- 19. Development of Targeted Therapies -- Evolution of Clinical Trialsin CRC -- Promising Targets and Drugs in Development for CRC -- Future Directions and Study Designs in Adjuvant CRC -- Future Directions and study Designs in metastatic CRC -- Conclusions -- References -- 20. Future Directions in the Treatment of Colorectal Cancers: Designs for Biomarker-Driven Clinical Trials -- Introduction -- Prognostic Biomarkers -- Predictive Biomarkers -- Discussion -- References -- 21. Colon Cancer Survivorship -- Introduction -- Complications of Acute CRC Treatment -- Screening -- Preventive Health Maintenance -- Conclusion -- References -- 22. Patient Advocacy: What Does that Mean, and Why should I Care? -- Advocating for Oneself -- Personal Statement about Advocacy -- Engaging with Patient Advocacy Organizations -- References -- Index.