Cover -- Title -- Copyright -- Contents -- Series Foreword -- Preface -- Contributors -- Part I: Cervical Cancer and Precancerous Lesions -- Chapter 1: The Biology of Human Papillomavirus and the Etiology of Female Genital Tract Cancers -- Viral Structure and Genomic Organization -- Viral Life Cycle -- Tissue-Specific Pathogenesis -- Biological Markers of Progression -- Clinical Models For HPV-related Disease -- References -- Chapter 2: Cervical Cancer Prevention: HPV Vaccines -- HPV Vaccine Development -- References -- Chapter 3: Cervical Cancer Prevention: Screening and Diagnostic Accuracy -- Cervical Cancer Screening and the Papanicolaou (PAP) Smear -- High-Risk Human Papillomavirus (HPV) Testing -- The Role of Colposcopic Biopsies -- Molecular Markers of HPV-Mediated Neoplastic Transformation -- Improved Diagnostic Accuracy using Neoplastic Markers -- Future Screening -- References -- Chapter 4: Management of Cervical Dysplasia and Precancerous Lesions -- Colposcopic Terminology -- Human Papillomavirus (HPV) Positive, Cytology Negative -- HPV Negative, Ascus Cytology -- HPV Positive, Ascus Cytology or LSIL or More Severe Cytology Regardless of HPV Status -- CIN1 with ASCUS, ASC-H, or LSIL Cytology -- CIN1 with HSIL or AGC Cytology -- CIN2,3 -- CIN2,3 in Adolescent and Young Women -- AIS -- Pregnancy -- HIV-Positive Women -- References -- Chapter 5: Management of Recurrent Cervical Cancer -- Background -- Surveillance -- Local Recurrences After Primary Surgical Management -- Local Recurrences After Radiotherapy -- Distant Recurrences or Nonoperable Local Recurrences -- Conclusion -- References -- Chapter 6: Multimodality Treatment of Rare Cervical Cancer -- Rare AC -- GCC -- Conclusion -- References -- Chapter 7: Principles of Radiation Therapy for Cervical Cancer -- Introduction -- EBRT -- Brachytherapy -- Indications and Treatment Outcomes.

References -- Part II: Multidisciplinary Approach to Cancer of the Uterine Corpus -- Chapter 8: Surgical-Pathologic Features of Uterine Cancers -- Endometrial Carcinoma -- Endometrial Hyperplasia -- Practical Considerations on Endometrial Biopsy -- References -- Chapter 9: Multidisciplinary Approach to Treatment of Endometrioid Uterine Carcinoma -- Surgery for Early Endometrial Cancer -- Surgery for Advanced Endometrial Cancer (stage III-IV) -- References -- Chapter 10: Principles of Radiation Therapy for Uterine Cancers -- Adjuvant Radiation -- Advanced Disease -- Recurrent Disease -- Medically Inoperable Patients -- Future Studies -- Summary -- References -- Chapter 11: Multidisciplinary Management of Serous Carcinoma of the Endometrium -- Epidemiology, Molecular Pathogenesis, and Biologic Behavior -- Diagnosis, Management, and Prognosis -- Emerging Therapies -- Summary -- References -- Chapter 12: Multidisciplinary Approach to Diagnosis and Treatment of Uterine Sarcomas -- Uterine Leiomyosarcoma -- Endometrial Stromal Sarcomas -- Other Sarcomas -- Conclusions -- References -- Part III: Epithelial Ovarian Cancer -- Chapter 13: Molecular Pathogenesis of Ovarian Cancer -- Introduction -- Etiology of Sporadic Epithelial Ovarian Carcinoma -- Earliest Recognizable Processes in Tumor Progression -- Genetic and Protein Alterations in Ovarian Cancer -- References -- Chapter 14: Current Status of Inherited Predisposition Toovarian Cancer: Lessons From Familial Ovarian cancer Registries in the United Kingdom and the United States -- Inherited Ovarian Cancer -- High-risk Genes -- Non-high-risk Alleles -- Conclusions -- References -- Chapter 15: Surgical Management of Ovarian Cancer -- Introduction -- Preoperative Considerations -- Surgical Staging -- Tumor Debulking -- Palliative Surgery -- Conclusions -- References.

Chapter 16: Multidisciplinary Approach to Treatment of Epithelial Ovarian Carcinoma -- Epidemiology -- Pathology -- Origin/etiology -- Primary Treatment-surgery -- Primary Treatment-neoadjuvant Chemotherapy -- Primary Adjuvant Treatment-chemotherapy -- Chemotherapy For Recurrent Disease -- Poly Adp-ribose Polymerase Inhibitors -- Quality of Life -- References -- Chapter 17: Recurrent Ovarian Cancer: Approach to Diagnosis and Treatment -- Introduction -- Recurrent Ovarian Cancer:defining Recurrence -- Recurrent Ovarian Cancer:treatment -- References -- Part IV: Borderline Ovarian Tumors -- Chapter 18: A Multidisciplinary Approach to Diagnosis and Treatment of Borderline Ovarian Tumors -- Introduction -- Epidemiology -- Histology -- Pathogenesis -- Serous Borderline Tumors -- Mucinous Borderline Tumors -- Prognostic Factors -- Symptoms -- Surgical Treatment -- Fertility After Conservative Management of Borderline Ovarian Tumors -- Adjuvant Therapy of Borderline Ovarian Tumors -- Restaging -- Follow-up -- Future Direction in Borderline Ovarian Tumors -- Conclusion -- Acknowledgment -- References -- Part V: Germ Cell Tumors of the Ovary -- Chapter 19: Germ Cell Tumors of the Ovary: Multidisciplinary Approach to Diagnosis and Treatment -- Introduction -- Multidisciplinary Approach to Diagnosis -- Multidisciplinary Approach to Treatment -- References -- Chapter 20: Nonepithelial Ovarian Cancer -- Introduction -- Sex-cord Stromal Tumors -- Conclusions -- References -- Resources -- Part VI: Cancer of the Vulva -- Chapter 21: Precancerous Lesions of the Vulva -- References -- Chapter 22: Multidisciplinary Approach to Diagnosis and Treatment of Early Cancer -- Staging -- Management of Stage I and Stage II Vulvar Cancer -- References -- Chapter 23: The Role of Sentinel Lymph Node Mapping -- References -- Part VII: Gestational Trophoblastic Disease.

Chapter 24: Choriocarcinoma -- Introduction -- Acknowledgments -- References -- Chapter 25: Placental Site Trophoblastic Tumor -- Introduction -- Pathology -- Clinical Presentation and Diagnosis -- Imaging -- Staging -- Prognostic Factors -- Treatment Modalities -- Special Issues: Fertilitypreservation -- Key Points -- References -- Part VIII: Future Directions in the Treatment of Gynecologic Cancers -- Chapter 26: Laparoscopy and Robotic-assisted Surgery in Gynecologic Oncology -- Ovarian Tumors -- Cervical Cancer -- Endometrial Cancer -- Conclusions -- References -- Chapter 27: Innovations in Radiotherapy of Gynecologic Cancers -- Introduction -- Intensity-modulated Radiation Therapy -- Image-Guided Radiotherapy -- Stereotactic Body Radiotherapy -- Conclusions -- References -- Chapter 28: Parp Inhibitors in Gynecologic Malignancies -- Mechanisms of DNA Repair -- Clinical Development of Parp Inhibitors -- Challenges with Future Drug Development and Trials -- References -- Chapter 29: Hormonal Treatment in Gynecologic Oncology -- Progesterone Therapy For Early Endometrial Cancer -- Therapy For Advanced And Recurrent Endometrial Cancer -- Hormonal Therapyof Ovarian Cancer -- Conclusions -- References -- Chapter 30: Genomic and Proteomic Biomarkers For Ovarian cancer Screening, Prognosis, and Individualization of Chemotherapy -- Introduction -- Cancer Genomics -- Biomedical Genomic Techniques -- Transcriptional Profiling Predicts the Clinical Behavior of Epithelial Ovarian Cancer -- Focal Genetic LOCI -- From Genomics to Proteomics -- Biomarkers -- Proteomic Techniques -- Posttranscriptional Profiling to Predict the Clinical Behavior of EOC -- Conclusions -- References -- Chapter 31:incorporating Translational Research Intogynecologic Cancers While Balancing the Focus of Personalized Medicine -- Defining Translational Research.

Genomic Analysis of Epithelialovarian Cancer -- Some Examples of Progress from Translational Research in Gynecologic Cancer, Mainlyovarian Cancer -- Biospecimen Science is Criticalto Success of Translational Research and Personalizedmedicine -- Biomarkers and Targetedtherapy-an Example of the complexity When Trying Toimplement Personalized Medicine -- Expanding the View -- References -- Chapter 32: Integrative Medicine in Gynecologic Oncology -- Definition and History -- Epidemiology -- Massage Therapy -- Mind-body Medicine -- Music Therapy -- Physical Activity -- Nutrition -- Dietary Supplements -- Posttreatment Sexual Dysfunction and Menopausal Symptoms -- Potential Risks of complementary Medicine -- Conclusions -- References -- Chapter 33: Multidisciplinary Palliative Care -- Introduction -- Definitions -- Scope of Service -- Goals of Care -- Prognostication -- Sharing Bad News -- Setting Alternative Goals -- Symptom Control -- Pain -- Management of Bowelobstruction -- Depression -- Delirium/agitation -- Hospice -- Care in the Last Hours of Life -- Ethics -- References -- Index.