Cover -- Title page -- Copyright page -- Contents -- Preface -- Contributors -- 1: "The Genetic Tool-Kit": The Life-History of an Important Metaphor -- Introduction -- Historical Background to the Term -- From "Homeotic Genes" (and "Homeoboxes") to the General Idea of Key Regulatory Genes with Conserved Developmental Functions -- The Genetic Tool-Kit: The Seminal Findings That Led to its Coinage and the Key Idea -- The Genetic Tool-Kit as a Non-Answer to the Question of Evolutionary Diversification within the Animal Kingdom -- Thinking about How GRNs Are "Rewired": Two Approaches -- Conclusions -- Acknowledgments -- References -- 2: The Evolution of Sex Determination in Animals -- Introduction -- Evo-Devo of Sex Determination -- The Origin of Network Novelty -- Evolution of Genotypic Sex Determination -- The Developmental Basis of GSD -- Evolutionary Transitions between Genotypic Sex-Determining Systems -- GSD and the Evolution of Sex Chromosomes -- Evolution of Environment-Dependent Sex Determination -- The Developmental Basis of ESD -- Evolutionary Transitions between Environment-Dependent Sex-Determining Systems -- From ESD to GSD and Back Again -- Suggestions for Future Work -- Acknowledgments -- References -- 3: The Evolution and Development of Eusocial Insect Behavior -- The Path from Solitary Life to Advanced Social Living -- Eusociality: Defining the Extremes of Social Life -- The Starting Point: A Solitary Life Cycle -- Aggregations -- Communal Nesting -- Primitive Eusociality -- Advanced Eusociality -- Ultimate Explanations for Reproductive Division of Labor -- What Could Natural Selection Act Upon to Build Eusocial Insect Societies? -- Genomic Approaches -- A Targeted Approach: Social Co-Option of Solitary Ground Plans -- Reproductive Physiology as a Behavioral Regulator -- Reproductive Ground Plan Hypothesis.

Epigenetics: A New Understanding of the Regulation of Social Life -- Genomic Patterns of DNA Methylation: A Substrate for Natural Selection? -- The Proposed Functional Roles of DNA Methylation -- The Role of DNA Methylation in Eusocial Developmental Plasticity and Evolution -- The Putative Role of DNA Methylation in Behavior and Social Behavioral Evolution -- Social Insect Evolution: A Quickly Advancing Field -- References -- 4: Evo-Devo on Chip -- Introduction -- Interrogating Developmental Mechanisms in Drosophila melanogaster Using Microdevices -- Microfluidic Advances for Developmental and Behavioral Studies in C. elegans -- Microfluidic Culture Systems for Studying Genetic and Environmental Effects on D. rerio Development -- Mammalian Embryonic Development in Microsystems -- Conclusion -- References -- 5: From Black and White to Shades of Gray: Unifying Evo-Devo through the Integration of Molecular and Quantitative Approaches -- Introduction -- The Geometry of Development: A Quantitative Approach -- A Brief Review of GMs -- How GM Can Be Used to Study the Evolution of Development -- Size and Shape Relationships: How Can Allometry Inform Us about the Process of Evolution? -- Plasticity and Environmental Canalization: How Does the Environment Affect Development and Evolution? -- Using Integration and Modularity to Understand How Phenotypes Evolve -- The First Steps Toward a Synthesis: GM Enables Quantitative Shifts in Anatomy to Be Linked to Discrete Molecular Processes -- The Broad Applicability of Shades of Gray: Using GM to Connect Micro- and Macro-Level Patterns of Divergence -- Ontogenetic Theories of Phenotypic Divergence -- A Brief Review of Ontogenetic Theories of Evolution -- A Refined Ontogenetic Theory for Divergence in Quantitative Traits -- Testing the Role of Ontogeny in Microevolution -- Conclusions -- Acknowledgments -- References.

6: Advances in Understanding Limb Regeneration in a Developmental and Evolutionary Context -- Introduction -- What Is Regeneration? -- Regeneration or Redevelopment? -- Limb Regeneration Mirrors Embryonic Limb Development with Several Key Differences -- Confounding Differences between Limb Regeneration and Limb Development -- The Origin of the Regenerate: Are Blastema Cells Pluripotent or Lineage-Restricted? -- Is Regeneration the True Ancestral State? -- Selective Loss of Regenerative Ability -- Convergent Evolution of Limb Regeneration -- Final Thoughts -- References -- 7: Ectodermal Organ Stem Cells: Morphogenesis, Population Regenerative Behavior, and Evo-Devo -- Physiological Regeneration of Ectodermal Organ Stem Cells -- Episodic Stem Cell Regeneration -- Follicle Configuration for Stem Cell Niche -- Feather Regeneration: Stem Cell Homeostasis and Morphogenesis -- Stem Cell Homeostasis -- Feather Branching Morphogenesis -- Evolution of Feathers -- Diverse Forms in Feathered Dinosaurs -- Evo-Devo of Feather Forms -- Hair Regeneration: Population Behavior in Regeneration -- New Hair Cycle Phases Due to Micro- and Macro-Environmental Interaction for Stem Cells -- Activator/Inhibitor Modulation -- Regenerative Hair Waves in Transgenic Mice and Different Mammalian Species -- Wave Patterns in Different Animals -- Regenerative Behavior in a Large Population of Stem Cells -- Acknowledgments -- References -- 8: Perspectives in Evo-Devo of the Vertebrate Brain -- Introduction -- Emergence of the Vertebrate Forebrain in Early Chordates and Its Diversification -- The Telencephalon Is a Vertebrate Novelty -- A Major Role for Signaling Centers in the Emergence of the Vertebrate Brain -- Evo-Devo of Signaling Centers as Drivers of Forebrain Microevolution -- Developmental Control of the Evolution of Brain Size and Relative Brain Region Size.

Evo-Devo of Proliferation in Vertebrates -- Evo-Devo of Progenitor Types -- Evolution of cis-Regulation of Brain Developmental Genes -- Evolutionary Conservation in cis-Regulation -- Evolutionary Modifications in cis-Regulation -- Conclusion -- References -- 9: Evolution and Development of Language -- Background -- Genes and Pathways -- Life History -- Disorders of Language -- Future Directions -- Acknowledgments -- References -- 10: Advancing Evolutionary Developmental Biology -- Introduction -- From Snapshots to Moving Pictures -- Very Early and Very Late -- The Missing Pieces -- Summary: Advancing Evolutionary Development -- Evolution Exploits Developmental Redundancy -- Development Never Stops -- Organisms Do Amazing Things -- Acknowledgments -- References -- Index.