
Wiley-Blackwell Handbook of Psychoneuroimmunology.
Title:
Wiley-Blackwell Handbook of Psychoneuroimmunology.
Author:
Kusnecov, Alexander W.
ISBN:
9781118314760
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (554 pages)
Contents:
The Wiley-Blackwell Handbook of Psychoneuroimmunology -- Contents -- Preface -- Foreword -- List of Contributors -- 1 Basic Principles in Immunology: Relevance for Studies in Psychoneuroimmunology -- Introduction -- The Components of the Immune System -- Cytokines and chemokines - the immune system's messengers -- The cells of the immune system -- Modes of Immunity -- The Immune System and the Brain -- Methods in Immunology with Relevance for Psychoneuroimmunology -- Lipopolysaccharides -- Nucleic acids -- Superantigens -- Proteins -- Cytokines -- Live infectious agents -- Immune Processes and their Clinical Consequences on Mental Health -- Concluding Remarks -- References -- 2 Innervation of the Immune System -- Basic Organization of the Autonomic and Sensory Systems -- Overview of the ANS -- Overview of the sensory system -- Innervation of Lymphoid Organs -- Bone marrow -- Thymus -- Spleen -- Lymph nodes -- Functional significance of sympathetic innervation in secondary lymphoid organs: lymph nodes and spleen -- Innervation of Diffuse Lymphatic Tissue or Mucosa-Associated Lymphoid Tissue (MALT) -- No Parasympathetic Innervation of Immune Organs -- The Role of the Vagus Nerve and the Cholinergic Anti-inflammatory Reflex -- Sensory Innervation of Immune Organs -- The Role of Sensory Nerves in Immune Regulation -- Summary of Innervation of the Immune System -- References -- 3 In Vitro and In Vivo Assessment of Immune System Modulation of Brain Function and Neurochemistry -- Overview -- Approaches to Assessing Brain Changes Associated with Immune and Cytokine Challenges -- Analysis of brain neurochemistry -- Analysis of Neuron Function Alterations by Cytokines -- Neuronal cell culture -- Brain slices -- In vivo recordings -- What has electrophysiology told us about immune function and brain activity? -- Summary -- Acknowledgments -- References.
4 Control and Contributions of the Blood-Brain Barriers to Cytokine Levels in the CNS -- Overview -- The Blood-Brain Barrier -- The Blood-Brain Barrier and the Immune Privileged CNS -- Restrictive barrier function -- The transport of cytokines across the BBB -- Secretion of immunoactive substances by the BBBs -- Other mechanisms by which the BBB could control brain cytokines -- Conclusions -- References -- 5 The Immune-Neuroendocrine Network in Health and Disease -- Introduction -- Historical Perspective and Views: The Immune and Nervous System Talk to Each Other -- Cytokines Mediate a Resetting of the INE Network During Immune and Inflammatory Responses -- Cytokines can take command of homeostasis during disease -- The neuronal-cytokine network in the healthy brain -- Pathophysiological Consequences of Alterations in the INE Network -- Disruption of immune-brain communication during autoimmune, lymphoproliferative, and inflammatory diseases -- Deleterious Effects of the INE Network During Prolonged Infections: Pulmonary Tuberculosis as an Example -- Conclusions and Proposal -- Acknowledgements -- References -- 6 Neural Functions of Hematopoietic-derived Cells -- Introduction -- The Blood-Brain Barrier, Past to Present -- The choroid plexus -- The circumventricular organs (CVO) -- Transport Systems -- The implications of directionality in BBB transport -- Immune Privilege Revisited -- Peripheral immune cells - not just in the periphery -- CNS immune traffic - molecular interactions -- Immune system-CNS Crosstalk -- CNS-immune communication: Direct, bidirectional, and necessary -- The Immune System in Response to Neuroinflammation and Neurodegeneration -- T-cells in the resolution of acute CNS injury -- T-cells in the resolution of chronic CNS neurodegeneration -- The Immune System and Higher Brain Function -- Autoimmune T-cells in learning and memory.
IL-4 and cognition: The importance of meningeal immunity -- Meningeal myeloid cells as key players in cognitive disorders -- Summary Conclusions -- References -- 7 Immunoregulatory Neuropeptides -- Bidirectional Communication between the CNS and the Immune System -- Innate and Adaptive Immune Responses -- Immunomodulatory Neuropeptides -- Pro-inflammatory Neuropeptides -- Anti-inflammatory Neuropeptides -- Endogenous VIP: sources and immunoregulatory role -- VIP receptors in immune cells -- Effects of VIP on Innate Immune Cells -- Effects on cytokine/chemokine production -- Signaling pathways -- Effects of VIP in Adaptive Immunity -- Effects on T-cell activation and proliferation -- VIP promotes TH2 differentiation -- Does VIP affect TH17 differentiation? -- VIP induces Treg -- NPs as Natural Antimicrobial Peptides -- NP: Therapeutic Perspective -- Conclusions -- References -- 8 Regulation of Immune Cell Activity by Norepinephrine and β2-Adrenergic Receptor Engagement -- Introduction -- Innervation of Lymphoid Tissue, Release of Norepinephrine, and Adrenergic Receptor Expression -- Activation of Molecular Pathways and Signaling Intermediates -- Gαs signaling in B-cells mediates the NE/β2AR-induced change in the antibody response -- Gαi signaling in macrophages mediates the NE/β2AR-induced change in cytokine production -- GRK/β-arrestin signaling is independent of PKA activation, but mediates a change in inflammatory response and immune cell migration -- General considerations about the temporal relationship among multiple β2AR-activated molecular pathways -- Clinical Implications -- IgE and allergic asthma -- Antibody production and immunity -- Conclusions -- References -- 9 Immune-to-Brain Communication in Pain: Historical Perspectives, New Directions -- Introduction -- Pathological Pain Processing: A Neuronal Perspective.
The peripheral nociceptive pathway -- The central nociceptive pathway -- Pathological pain processing -- The Immune Contribution to Pathological Pain Processing -- How do Glia Become Activated Following Nerve Injury? -- Glial activation: Toll-like receptors -- Glial activation: cytokines and chemokines -- Glial activation: ATP -- Glial activation: signal transduction and transcription factors -- What are the Consequences of Glial Activation for Pathological Pain Processing? -- Peripheral Immune Contributions to Pathological Pain Processing -- The Flip-Side: The Protective Role of the Immune System Following Nerve Injury -- The Immune System as an Alternative Pharmacological Target for Neuropathic Pain -- Future Directions -- References -- 10 Stress and Neuroendocrine-Immune Interaction: A Therapeutic Role for β-endorphin -- Physiology of Stress: General Overview -- Stress Effects on Development: Critical Periods -- Prenatal period -- Postnatal period -- Period of adolescence -- Stress Effects on Immune Function -- Role of β-endorphin in the Control of the Stress Response -- Role of β-endorphin in the Control of Immune Regulation -- β-endorphins as Treatment -- Stress Effects on Health -- References -- 11 Assessing Neuroendocrine-Mediated Modulation of Immunity to Infection in Animals: Caveats and Methodological Issues -- Introduction to Stress-Neuroendocrine-Immune Interactions -- Human Studies - A Broad Perspective -- A variety of real-life stressors -- Stress-mediated modulation of immune function -- Limitations of human studies -- Animal Studies - A Broad Perspective -- Strengths of animal studies -- Decreased experimental variability -- Increased opportunity to assess immune function -- Choice of experimental pathogen -- Developing Animal Models of Stress -- Introduction -- Choosing the species -- Types of experimental stressors.
Duration/frequency of stress - acute versus chronic -- Unique features of a chronic stressor -- Using Animal Models to Study Stress-Induced Neuroendocrine-Activation -- Introduction -- Assessing neuroendocrine involvement in stress-immune interactions -- Using Animal Models to Study Stress-Induced, Neuroendocrine-Mediated Modulation of the Immune Response to Infections -- Introduction -- Assessing immune function -- Assessing Immune Involvement in Stress-Immune-Pathogen Interactions -- Infection as a modulator of immune function -- Stress as a modulator of immune function -- The role of experimental variables in defining the nature of neuroendocrine-immune interactions -- Recent Developments and Future Directions -- Introduction -- Cellular and molecular immune cell changes -- Cell-to-cell interactions -- Maternal-fetal programming -- Technological advances -- Counteracting the effects of stress on immune function -- Conclusions -- References -- 12 Approaches to Assessing Stressor-Induced Cytokine and Endocrine Changes in Humans -- Stressor Appraisals and Coping in Humans -- Laboratory-based Stressor Paradigms -- Trier Social Stress Test (TSST) -- Social rejection -- Reminders of a stressful event -- Acute Versus Chronic Stressor Experiences and the Morning Cortisol Rise -- Pre-Post Paradigms in Natural Settings -- Individual Difference Factors that Influence Stress Responses -- Summary -- Acknowledgements -- References -- 13 Stress and Immune Function in Humans: A Life-Course Perspective -- Early Childhood Stress and Inflammation -- Inflammatory cytokines and depression -- Psychoneuroimmunology and Adaptive Immunity -- The Neuroendocrine Stress Response and Immunity -- Acute stress and immune responses -- Aging and Immunosenescence -- Neuroendocrine changes and aging -- Inflammation and aging -- Adaptive immunity and aging.
Psychosocial Interventions and Immunological Outcomes.
Abstract:
This comprehensive resource details the history, methodology and development of research into psychoneuroimmunology, balancing it with meticulous coverage of both the clinical aspects and practical applications of the subject. A much-needed reference including overviews of key advances in the field Discusses how psychoneuroimmunological research is conceived and executed Includes contributions from a wealth of experts in the field Forward by Robert Ader and Nicholas Cohen, founders of the discipline Authoritative and interdisciplinary in scope - integrating biological and behavioral science.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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