
MicroRNAs in Medicine.
Title:
MicroRNAs in Medicine.
Author:
Lawrie, Charles H.
ISBN:
9781118300411
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (722 pages)
Contents:
Cover -- Title page -- Copyright page -- Contents -- Foreword -- Preface -- Contributors -- 1: MicroRNAs: A Brief Introduction -- I. A Short History of Small RNAs -- II. Biogenesis of miRNAs -- A. miRNA Nomenclature: What's in a Name? -- III. miRNA Function: Controlling mRNA Stability, Degradation, and/or Translation -- IV. Regulating the Regulators: miRNA Control and Dysfunction in Disease -- A. Genetic Dysregulation of miRNA Expression -- B. Epigenetic Regulation -- C. Transcription Factors and miRNA Regulatory Networks -- D. Regulating miRNA Synthesis and Processing -- E. Control of miRNA Function -- V. Present and Future Perspectives for miRNAs in Medicine -- A. Deciphering the miRNA Targetome: Understanding the Functional Consequences of miRNA Dysregulation in Disease -- B. Tip of the Non-Coding RNA Iceberg -- C. Are miRNAs Clinically Useful Molecules? -- References -- PART I: MicroRNAs as Physiological Regulators -- 2: MicroRNA Regulation of Stem Cell Fate and Reprogramming -- I. Introduction -- A. About Stem Cells -- II. MicroRNAs in Pluripotency and Establishment of Different Lineages -- A. MicroRNAs in Embryonic Stem Cells (ESc) -- B. Maintenance of the Pluripotent State through Controlling the Cell Cycle -- C. MicroRNAs in Pluripotency versus Differentiation Fate Choice -- III. MicroRNAs, Induced Pluripotency, and Transdifferentiation -- A. Induced Pluripotency and MicroRNAs -- B. Underlying Mechanisms in microRNA iPSc Generation -- C. Transdifferentiation and miRNAs -- IV. Conclusion -- Acknowledgments -- References -- 3: MicroRNAs as Regulators of Immunity -- I. Introduction -- II. Innate Immunity and miRNAs -- A. Granulocytes -- B. Monocytes and Macrophages -- C. Dendritic Cells -- D. NK and NKT Cells -- E. Mast Cells -- III. Adaptive Immunity and miRNAs -- A. B Lymphocytes -- B. T Lymphocytes -- IV. Conclusions and Future Directions.
References -- 4: Regulation of Senescence by microRNAs -- I. Introduction: Senescence -- A. Senescence of Cultured Cells -- B. Senescence In Vivo -- C. Detection of Senescent Cells -- II. Posttranscriptional Regulation of Senescence by miRNAs -- A. miRNA Regulation of the p53/p21/Arf Pathway -- B. miRNA Regulation of the p16/Rb Pathway -- C. miRNA Regulation of SASP -- D. miRNAs Modulating Transcriptional and Posttranscriptional Regulators of Senescence -- E. Senescence Regulation of miRNA Biogenesis -- III. Impact of SA-miRNAs on In Vivo Senescence -- IV. Concluding Remarks and Future Perspectives -- Acknowledgments -- References -- 5: The Emergence of GeroMIRs: A Group of MicroRNAs Implicated in Aging -- I. Introduction -- II. MiRNAs and Aging: Lessons from Invertebrates -- III. Changes in miRNA Expression during Mammalian Aging -- IV. MiRNA Modulation of Mammalian DNA Damage -- V. Micromanaging of Other Aging-Associated Pathways in Mammals -- VI. Conclusions and Future Perspectives -- References -- 6: MicroRNAs and Hematopoiesis -- I. Introduction -- A. MicroRNAs and Hematopoiesis -- B. Hematopoietic Lineages -- II. Lymphocyte Development -- III. Monocyte and Granulocyte Development -- IV. Erythrocyte and Megakaryocyte Development -- V. Conclusions -- References -- 7: MicroRNAs in Platelet Production and Activation -- I. Introduction -- II. miRNA Biogenesis and Function -- III. miRNAs and Megakaryocytopoiesis -- A. miR-155 -- B. miR-150 -- C. miR-146a -- D. miR-34a -- E. Other miRNAs -- IV. Platelet miRNAs -- V. Platelet miRNAs as Biomarkers -- VI. Platelet Microparticles and miRNAs -- VII. Summary and Future Directions -- References -- PART II: MicroRNAs in Infectious Disease: Host-Pathogen Interactions -- 8: MicroRNAs as Key Players in Host-Virus Interactions -- I. Introduction -- II. Host miRNAs and Virus Infection -- III. Viral miRNAs.
A. MicroRNAs Encoded by DNA Viruses -- B. MicroRNAs Encoded by RNA Viruses -- C. Expression of Viral miRNAs -- IV. Biological Roles of Viral miRNAs -- A. Functional Convergence of Viral miRNAs -- B. Toward Complete Viral miRNA Targetomes -- C. Role of Viral miRNAs In Vivo -- V. Conclusions and Future Prospects -- Acknowledgments -- References -- 9: MicroRNA Expression in Avian Herpesviruses -- I. Introduction -- II. Avian Herpesviruses and Associated Diseases -- III. Identification of miRNAs Encoded by Avian HerpesvirusES -- A. MDV-1 miRNAs -- B. MDV-2 miRNAs -- C. HVT miRNAs -- D. ILTV-miRNAs -- E. DEV miRNAs -- IV. Viral Orthologues of Host miRNAs -- V. Target Identification of Avian Herpesvirus miRNAs -- A. Viral Targets of Viral miRNAs -- B. Cellular Targets of Viral miRNAs -- VI. Conclusions -- Acknowledgment -- References -- 10: Function of Human Cytomegalovirus MicroRNAs and Potential Roles in Latency -- I. Introduction to Human Cytomegalovirus -- II. Identification of Human Cytomegalovirus miRNAs -- III. Human Cytomegalovirus miRNAs: Creating an Environment Conducive to Latency -- A. HCMV miRNAs and Repression of IE Gene Expression -- B. HCMV miRNAs and Host Immune Evasion -- C. Cellular miRNAs and HCMV -- D. The Future of HCMV miRNA Target Identification -- IV. Conclusions -- References -- 11: Involvement of Small Non-Coding RNA in HIV-1 Infection -- I. Introduction -- II. miRNAs, siRNAs, and tdsmRNAs -- III. Regulation of miRNAs by HIV Infection -- A. Perturbation of the miRNA Biogenesis Pathway by HIV-1 Infection -- B. Perturbation of miRNA Expression Profiles by HIV-1 Infection -- IV. Regulation of HIV-1 Infection by Host miRNAs -- V. sncRNAs in Virally Infected Cells -- A. HIV-1 Naturally Encoded sncRNAs -- B. HIV-1 Artificially Encoded sncRNAs -- VI. tRNA-Derived sncRNAs and HIV-1 -- VII. Concluding Remarks -- Acknowledgment.
References -- 12: MicroRNA in Malaria -- I. Introduction: Malaria as a Disease -- II. The Pathogenesis of Severe Malaria -- A. Sequestration and Cytoadherence -- B. Reduction of Microvascular Flow -- C. Endothelial Activation and Dysfunction -- D. Cytokines and Host Immune Response -- III. miRNAs and Malaria -- A. miRNA in Malaria Parasites -- B. miRNA in Mosquito Stages -- C. miRNA in the Host Response to Malaria Infection -- IV. Potential Roles for miRNAs in Regulating Host Response to Pathophysiological Mechanisms -- A. Hypoxia -- B. Apoptosis and Programmed Cell Death -- C. Endothelial Activation -- D. Central Nervous System (CNS) Injury in CM -- V. Conclusions and Future Research Directions -- References -- PART III: Cancer -- 13: The MicroRNA Decalogue of Cancer Involvement -- I. Introduction -- II. The Decalogue of Principles of miRNA Involvement in Human Cancers -- III. Conclusion -- References -- 14: MicroRNAs as Oncogenes and Tumor Suppressors -- I. Introduction -- II. miRNA Targets -- III. Role of miRNAs in Cancer -- A. miRNAs That Function as Oncogenes -- B. miRNAs That Function as Tumor Suppressors -- IV. miRNAs and Their Future Use in the Clinic: Diagnosis, Prognosis, and Therapy -- References -- 15: Long Non-Coding RNAs and Their Roles in Cancer -- I. Introduction -- II. General Features of lncRNAs -- III. Classifications of lncRNAs -- IV. Functions and Mechanisms of lncRNAs -- A. lncRNAs and Transcriptional Regulation -- B. Epigenetic Regulation and lncRNAs -- C. lncRNAs in Posttranscriptional Regulation -- V. lncRNAs and Cancer -- A. lncRNAs with Abnormal Expression in Cancer: Tumor Suppressor and Oncogenic lncRNAs -- B. Genetic Alterations in lncRNAs Associated with Cancer -- VI. Future Perspectives -- Acknowledgments -- References -- 16: Regulation of Hypoxia Responses by MicroRNA Expression -- I. Hypoxia in Solid Tumors.
II. Hypoxia-Inducible Factors (HIFs) and Transcriptional Regulation upon Hypoxia Response -- III. MicroRNA (miRNA) Regulation under Hypoxia -- IV. miR-210 as Key Player in Hypoxia -- A. Discovery and Validation of miR-210 Targets -- B. miR-210 and Mitochondrial Functions -- C. miR-210 and Angiogenesis -- D. miR-210 and DNA Repair -- E. miR-210 and the Cell Cycle -- F. miR-210, Apoptosis, and Cell Differentiation -- G. miR-210 and Immunosuppression -- H. miR-210 as a Biomarker -- V. miRNA-Mediated Regulation of HIF -- A. miRNAs Regulated by HIF -- B. miRNAs Regulated by Hypoxia in a HIF-Independent Manner -- C. miRNAs Not Regulated by Hypoxia -- D. Interaction between Different Levels of miRNA Regulation under Hypoxia -- VI. Conclusions -- References -- 17: Control of Receptor Function by MicroRNAs in Breast Cancer -- I. Breast Cancer: Introduction -- II. MicroRNAs (miRNAs) in Breast Cancer: Diagnostic, Prognostic, and Predictive Biomarkers -- A. Aberrant Expression of miRNAs in Breast Cancer -- B. Use of miRNA Signatures to Predict Tumor Subtype -- III. ER and miRNAs -- A. The ER Family -- B. miRNA Regulation of ERs -- C. Estrogenic Regulation of miRNA Expression -- D. miRNAs and Endocrine Resistance in Breast Cancer -- IV. ErbB Receptor Signaling and miRNAs -- A. ErbB Signaling and Breast Cancer -- B. Regulation of EGFR Signaling by miRNAs -- C. Regulation of ErbB2 and ErbB3 Signaling by miRNAs -- D. The Influence of miRNA on HER2-Targeting Therapies -- V. Conclusions -- Acknowledgments -- References -- 18: MicroRNAs in Human Prostate Cancer: From Pathogenesis to Therapeutic Implications -- I. Introduction -- II. PCa Pathogenesis and miRNAs -- III. miRNA Profiling in PCa -- A. miRNAs as Oncomirs -- B. miRNAs as Tumor Suppressors -- IV. miRNAs and Their Targets in PCa -- V. miRNAs as Potential Markers for Diagnosis and Progression of PCa.
VI. miRNAs Modulating Tumor Progression and Metastasis in PCa.
Abstract:
MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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