Cover -- Microfluidic devices for biomedical applications -- Copyright -- Contents -- Contributor contact details -- Woodhead Publishing Series in Biomaterials -- About the editors -- Preface -- Part I Fundamentals of microfluidic technologies for biomedical applications -- 1 Materials and methods for the microfabrication of microfluidic biomedical devices -- 1.1 Introduction -- 1.2 Microfabrication methods -- 1.3 Materials for biomedical devices -- 1.4 Polymers -- 1.5 Conclusion and future trends -- 1.6 References -- 1.7 Appendix: acronyms -- 2 Surface coatings for microfluidic-based biomedical devices -- 2.1 Introduction -- 2.2 Covalent immobilization strategies: polymer devices -- 2.3 Covalent immobilization strategies: glass devices -- 2.4 Adsorption strategies -- 2.5 Other strategies utilizing surface treatments -- 2.6 Examples of applications -- 2.7 Conclusion and future trends -- 2.8 Sources of further information and advice -- 2.9 References -- 3 Actuation mechanisms for microfluidic biomedical devices -- 3.1 Introduction -- 3.2 Electrokinetics -- 3.3 Acoustics -- 3.4 Limitations and future trends -- 3.5 References -- 4 Digital microfluidics technologies for biomedical devices -- 4.1 Introduction -- 4.2 On-chip microdrop motion techniques -- 4.3 Sensing techniques -- 4.4 Future trends -- 4.5 Conclusion -- 4.6 References -- Part II Applications of microfluidic devices for drug delivery and discovery -- 5 Controlled drug delivery using microfluidic devices -- 5.1 Introduction -- 5.2 Microreservoir-based drug delivery systems -- 5.3 Micro/nanofluidics-based drug delivery systems -- 5.4 Conclusion -- 5.5 Future trends -- 5.6 References -- 6 Microneedles for drug delivery and monitoring -- 6.1 Introduction -- 6.2 Fabrication of microneedles (MNs) -- 6.3 MN design parameters and structure -- 6.4 Strategies for MN-based drug delivery.

6.5 MN-mediated monitoring using skin interstitial fluid (ISF) and blood samples -- 6.6 Future trends -- 6.7 Conclusion -- 6.8 References -- 7 Microfluidic devices for drug discovery and analysis -- 7.1 Introduction -- 7.2 Microfluidics for drug discovery -- 7.3 Microfluidics for drug analysis and diagnostic applications -- 7.4 Conclusion and future trends -- 7.5 Sources of further information and advice -- 7.6 References -- Part III Application of microfluidic devices for cellular analysis and tissue engineering -- 8 Microfluidic devices for cell manipulation -- 8.1 Introduction -- 8.2 Microenvironment on cell integrity -- 8.3 Microscale fluid dynamics -- 8.4 Manipulation technologies -- 8.5 Manipulation of cancer cells in microfluidic systems -- 8.6 Conclusion and future trends -- 8.7 Sources of further information and advice -- 8.8 References -- 9 Microfluidic devices for single-cell trapping and automated micro-robotic injection -- 9.1 Introduction -- 9.2 Device design and microfabrication -- 9.3 Experimental results and discussion -- 9.4 Conclusion -- 9.5 Acknowledgements -- 9.6 References -- 10 Microfluidic devices for developing tissue scaffolds -- 10.1 Introduction -- 10.2 Key issues and technical challenges for successful tissue engineering -- 10.3 Microfluidic device platforms -- 10.4 Conclusion and future trends -- 10.5 References -- 11 Microfluidic devices for stem cell analysis -- 11.1 Introduction -- 11.2 Technologies used in stem cell analysis -- 11.3 Examples of microfluidic platform for stem cell analysis: stem cell culture platform - mimicking in vivo culture conditions in vitro -- 11.4 Examples of microfluidic platform for stem cell analysis: single stem cell analysis -- 11.5 Microdevices for label-free and non-invasive monitoring of stem cell differentiation -- 11.6 Microfluidics stem cell separation technology.

11.7 Conclusion and future trends -- 11.8 Sources of further information and advice -- 11.9 References -- Part IV Applications of microfluidic devices in diagnostic sensing -- 12 Development of immunoassays for protein analysis on nanobioarray chips -- 12.1 Introduction -- 12.2 Technologies -- 12.3 Immobilization chemistry -- 12.4 Detection methods -- 12.5 Applications -- 12.6 Conclusion and future trends -- 12.7 References -- 13 Integrated microfluidic systems for genetic analysis -- 13.1 Introduction -- 13.2 Integrated microfluidic systems -- 13.3 Development of integrated microdevices -- 13.4 Applications of fully integrated systems in genetic analysis -- 13.5 Conclusion and future trends -- 13.6 References -- 14 Low-cost assays in paper-based microfluidic biomedical devices -- 14.1 Introduction -- 14.2 Fabrication techniques for paper-based microfluidic devices -- 14.3 Detection and read-out technologies -- 14.4 Application of paper-based microfluidic devices -- 14.5 Conclusion and future trends -- 14.6 References -- 15 Microfluidic devices for viral detection -- 15.1 Introduction -- 15.2 Microfluidic technologies used for viral detection -- 15.3 Examples of applications -- 15.4 Conclusion and future trends -- 15.5 Acknowledgements -- 15.6 References -- 16 Microfluidics for monitoring and imaging pancreatic islet and β-cells for human transplant -- 16.1 Introduction -- 16.2 Insulin secretory pathway: how glucose sensing and metabolic coupling translates to insulin kinetics -- 16.3 Technologies: the emergence of microfluidics applied to islet and β-cell study -- 16.4 Design and fabrication of the University of Illinois at Chicago (UIC) microfluidic device -- 16.5 Protocol: materials -- 16.6 Protocol: procedures -- 16.7 Anticipated results -- 16.8 Acknowledgements -- 16.9 References -- 17 Microfluidic devices for radio chemical synthesis.

17.1 Introduction -- 17.2 Medical applications of microfluidic radiochemistry: positron emission tomography (PET) and single photon emission computed -- 17.3 Advantages and disadvantages of microfluidic devices -- 17.4 Realization of promises: the superiority of microfluidic systems -- 17.5 Current problems for microfluidic technology -- 17.6 Recent developments with potential impact -- 17.7 Conclusion -- 17.8 References -- Index.