Cover -- Nanomedicine: Technologies and applications -- Copyright -- Contents -- Contributor contact details -- Woodhead Publishing Series in Biomaterials -- Dedication -- Part I Materials, properties and considerations -- 1 Introduction to nanomedicine -- 1.1 Introduction: basic concepts of nanomedicine -- 1.2 Public perception of nanomedicine -- 1.3 Scientific principles and applications of nanomedicine -- 1.4 Future trends in nanomedicine -- 1.5 References -- 2 Trends in nanomedicine -- 2.1 Introduction -- 2.2 The rise of nanomedicine -- 2.3 Diagnostics and medical records -- 2.4 Treatment -- 2.5 Future trends -- 2.6 References -- 3 Biomedical nanocrystalline metals and alloys: structure, properties and applications -- 3.1 Introduction -- 3.2 Synthesis and structure of nanocrystalline metals and alloys -- 3.3 Properties of nanocrystalline metals and alloys -- 3.4 Biocompatibility of nanocrystalline metals and alloys -- 3.5 Applications of nanocrystalline metals and alloys -- 3.6 Future trends -- 3.7 Sources of further information and advice -- 3.8 References -- 4 Nanoporous gold for biomedical applications: structure, properties and applications -- 4.1 Introduction -- 4.2 Medical applications -- 4.3 Biosensor applications -- 4.4 Alloy formation -- 4.5 Dealloying of gold-silver alloy -- 4.6 Mechanical properties of nanoporous gold -- 4.7 Electronic properties of nanoporous gold -- 4.8 Conclusions -- 4.9 References -- 5 Hydroxyapatite (HA) coatings for biomaterials -- 5.1 Introduction -- 5.2 Hydroxyapatite (HA) coatings -- 5.3 HA coatings by plasma spraying -- 5.4 Properties of plasma-sprayed coatings -- 5.5 Biomimetic HA coatings -- 5.6 HA coatings by sol-gel deposition -- 5.7 Miscellaneous deposition techniques for HA coatings -- 5.8 Conclusions -- 5.9 Future trends -- 5.10 Acknowledgement -- 5.11 References.

Part II Nanomedicine for therapeutics and imaging -- 6 Calcium phosphate-coated magnetic nanoparticles for treating bone diseases -- 6.1 Introduction -- 6.2 Iron oxide magnetic nanoparticle synthesis -- 6.3 Surface modification of iron oxide magnetic nanoparticles -- 6.4 Characterization of iron oxide magnetic nanoparticles -- 6.5 Biological applications of magnetic nanoparticles -- 6.6 Conclusions -- 6.7 Future trends -- 6.8 References -- 7 Orthopedic carbon nanotube biosensors for controlled drug delivery -- 7.1 Introduction -- 7.2 Carbon nanotubes for electrochemical biosensing -- 7.3 Carbon nanotube-based in situ orthopedic implant sensors -- 7.4 Electrically controlled drug-delivery systems for infection and inflammation -- 7.5 Critical issues in developing in situ orthopedic implantable sensors and devices -- 7.6 Conclusions -- 7.7 References -- 8 Nanostructured selenium anti-cancer coatings for orthopedic applications -- 8.1 Introduction -- 8.2 Selenium as an anti-cancer implant material -- 8.3 Nanostructured selenium coatings: a novel approach of using selenium to create anti-cancer biomaterials -- 8.4 In vitro biological assays for uncoated and selenium-coated metallic substrates -- 8.5 The effectiveness of titanium and stainless steel substrates -- 8.6 Coarse-grained Monte Carlo computer simulation of fibronectin adsorption on nanometer rough surfaces -- 8.7 Conclusions -- 8.8 References -- 9 Nanoparticulate targeted drug delivery using peptides and proteins -- 9.1 Introduction -- 9.2 Peptides and proteins for targeted drug delivery -- 9.3 Drug-peptide conjugates -- 9.4 Peptide-functionalized drug delivery systems -- 9.5 Peptide-targeted drug delivery across the intestine -- 9.6 Peptide-targeted drug delivery across the blood- brain barrier (BBB) -- 9.7 Peptide-targeted drug delivery for cancer applications.

9.8 Peptide-targeted drug delivery for the liver -- 9.9 Conclusions and future trends -- 9.10 References -- 10 Nanotechnology for DNA and RNA delivery -- 10.1 Introduction to DNA and RNA delivery -- 10.2 Advanced DNA/RNA delivery approaches in nanotechnology -- 10.3 Nanomaterial applications for DNA/RNA delivery -- 10.4 Novel vaccines -- 10.5 Molecular probes and images -- 10.6 Conclusions and future trends -- 10.7 References -- 11 Gold nanoshells for imaging and photothermal ablation of cancer -- 11.1 Introduction -- 11.2 The impact of cancer -- 11.3 Cancer biology -- 11.4 Nanotechnology and cancer treatment -- 11.5 Nanoshells -- 11.6 Conclusions and future trends -- 11.7 Sources of further information and advice -- 11.8 Acknowledgments -- 11.9 References -- 12 Microfluidics for testing and delivering nanomedicine -- 12.1 Introduction -- 12.2 Microfluidics -- 12.3 Testing of nanomedicine with microfluidic instruments -- 12.4 Delivery of nanomedicine using microfluidic technology -- 12.5 Nanoparticles -- 12.6 Conclusions and future trends -- 12.7 References -- 13 Zinc oxide nanowires for biomedical sensing and analysis -- 13.1 Introduction -- 13.2 Electrode growth and preparation -- 13.3 Sensors and functionalization -- 13.4 Measurement and results -- 13.5 Conclusions -- 13.6 References -- Part III Nanomedicine for soft tissue engineering -- 14 Nanotechnology and tissue-engineered organ regeneration -- 14.1 Introduction -- 14.2 Nanotechnology and tissue engineering -- 14.3 Nanotechnology and organ regeneration -- 14.4 Future trends and challenges -- 14.5 References -- 15 Rapid fabrication of biomimetic nanofiber-enabled skin grafts -- 15.1 Introduction -- 15.2 Autologous skin tissue engineering for wound healing -- 15.3 The effects of microenvironment on the formation of skin substitute.

15.4 Production of biomimetic nanofibers using electrostatic spinning -- 15.5 Layer-by-layer assembly of cells into 3-D constructs using electrospun nanofibers -- 15.6 Rapid formation of skin grafts using the nanofiber-enabled cell-layering approach -- 15.7 Future trends and challenges -- 15.8 Conclusion -- 15.9 Acknowledgment -- 15.10 References -- 16 Nanotubes for tissue engineering -- 16.1 Introduction -- 16.2 Nanotubes for tissue engineering -- 16.3 Nanotube applications in tissue engineering -- 16.4 Nanotubes and their effects -- 16.5 Conclusions -- 16.6 References -- 17 Self-assembled nanomaterials for tissue-engineering applications -- 17.1 Introduction -- 17.2 Peptide-based self-assembled nanomaterials -- 17.3 Applications of peptide-based materials in tissue engineering -- 17.4 Nucleic acid-based nanomaterials -- 17.5 Applications of rosette nanotubes (RNTs) in bone and cartilage tissue engineering -- 17.6 References -- Part IV Nanomedicine for bone and cartilagetissue engineering -- 18 Electrically active biocomposites as smart scaffolds for bone tissue engineering -- 18.1 Introduction -- 18.2 Composition and electrical properties of natural bone -- 18.3 Effect of an external E-field on cells -- 18.4 Development of hydroxyapatite (HA)-based bone replacement materials -- 18.5 Conclusions -- 18.6 Acknowledgement -- 18.7 References -- 19 Nanotechnology for cartilage and bone regeneration -- 19.1 Introduction -- 19.2 Cartilage repair and regeneration -- 19.3 Bone repair and regeneration -- 19.4 Future trends and conclusions -- 19.5 References -- 20 Nanostructured materials for bone tissue replacement -- 20.1 Introduction -- 20.2 The need for nano-engineered bone -- 20.3 Surface properties of orthopedic materials -- 20.4 Nano coating on conventional surfaces -- 20.5 Nanomaterials for orthopedic tissue engineering.

20.6 Future trends and ethical concerns -- 20.7 Conclusions -- 20.8 References -- 21 Nanocomposites for cartilage regeneration -- 21.1 Introduction -- 21.2 Design criteria and considerations for cartilage biomaterials -- 21.3 Biomaterials for cartilage regeneration -- 21.4 Scaffold fabrication -- 21.5 Conclusions and future trends -- 21.6 References -- Index.