Cover -- Title Page -- Copyright -- Contents -- List of contributors -- Foreword -- Preface -- About the companion website -- Chapter 1 Necropsy of the mouse -- 1.1 Recording of findings -- 1.2 Bleeding technique -- 1.3 Perfusion -- 1.4 External examination -- 1.5 Weighing of organs -- 1.6 Positioning of mouse for necropsy and removing the skin -- 1.7 Opening the abdominal cavity and exposing organs -- 1.8 Removing the ribcage to expose lungs and heart -- 1.9 Removing the brain and spinal cord -- 1.10 Collecting and fixing tissue samples -- References -- Chapter 2 Practical approaches to reviewing and recording pathology data -- 2.1 Sample selection and trimming patterns -- 2.2 Controls -- 2.3 Standardizing terminology -- 2.3.1 Macroscopic terminology -- 2.4 Microscopic terminology -- 2.5 Recording pathology data -- 2.5.1 Blinded versus unblinded review -- 2.5.2 Identifying differences between groups -- 2.6 Quantitative versus semiquantitative analysis -- 2.7 Semiquantitative techniques -- 2.8 Quantitative techniques -- References -- Chapter 3 Gastrointestinal system -- 3.1 Background and development -- 3.2 Oral cavity -- 3.2.1 Sampling teeth -- 3.2.2 Anatomy and histology of teeth -- 3.2.3 Sampling tongue -- 3.2.4 Anatomy and histology of tongue -- 3.3 Salivary glands -- 3.3.1 Sampling salivary glands -- 3.3.2 Anatomy and histology of the salivary glands -- 3.4 Stomach and intestines -- 3.4.1 Sampling stomach and intestines -- 3.4.2 Anatomy and histology of oesophagus -- 3.4.3 Anatomy and histology of stomach -- 3.4.4 Anatomy and histology of the intestines -- 3.5 Liver -- 3.5.1 Sampling liver -- 3.5.2 Anatomy and histology of the liver -- 3.6 Pancreas -- 3.6.1 Sampling pancreas -- 3.6.2 Anatomy and histology of the pancreas -- References -- Chapter 4 Cardiovascular system -- 4.1 Background and development.

4.2 Sampling techniques and morphometry -- 4.3 Artefacts -- 4.3.1 Perfusion artefacts -- 4.3.2 Contraction artefacts -- 4.4 Anatomy and histology of the heart -- 4.5 Anatomy and histology of the blood vessels -- References -- Chapter 5 Urinary system -- 5.1 Background and development -- 5.2 Sampling techniques -- 5.3 Artefacts -- 5.4 Background lesions -- 5.5 Anatomy and histology -- 5.5.1 Kidneys -- 5.5.2 Urinary bladder, ureter and urethra -- References -- Chapter 6 Reproductive system -- 6.1 Background and development of the male and female reproductive tract -- 6.2 Female reproductive tract -- 6.2.1 Sampling technique -- 6.2.2 Anatomy and histology -- 6.2.3 Oviduct -- 6.2.4 Uterus and cervix -- 6.2.5 Vagina -- 6.2.6 Clitoris and glands -- 6.2.7 Placenta -- 6.3 Male reproductive tract -- 6.3.1 Sampling techniques -- 6.3.2 Anatomy and histology -- References -- Chapter 7 Endocrine system -- 7.1 Introduction -- 7.2 Adrenals -- 7.2.1 Background and development -- 7.2.2 Sampling techniques -- 7.2.3 Artefacts -- 7.2.4 Anatomy and histology of the adrenals -- 7.3 Pituitary -- 7.3.1 Background and development -- 7.3.2 Sampling techniques -- 7.3.3 Artefacts -- 7.3.4 Anatomy and histology of the pituitary -- 7.4 Thyroids and parathyroids -- 7.4.1 Background and development -- 7.4.2 Sampling techniques -- 7.4.3 Artefacts -- 7.4.4 Anatomy and histology of the thyroids -- 7.4.5 Anatomy and histology of the parathyroids -- References -- Chapter 8 Nervous system -- 8.1 Introduction -- 8.2 Necropsy -- 8.3 Fixation/perfusion -- 8.4 Trimming -- 8.5 Special stains and techniques -- 8.6 Microscopic examination -- 8.7 Normal histology-juvenile-CNS and PNS -- 8.8 Artefacts-CNS and PNS -- 8.9 Pathological changes and background pathology-CNS and PNS -- 8.10 Acknowledgment -- References -- Useful website resources.

Chapter 9 Lymphoid and haematopoietic system -- 9.1 Introduction -- 9.2 Lymph nodes -- 9.2.1 Background and development -- 9.2.2 Sampling techniques -- 9.2.3 Artefacts -- 9.2.4 Anatomy and histology -- 9.3 Spleen -- 9.3.1 Background and development -- 9.3.2 Sampling techniques -- 9.3.3 Anatomy and histology -- 9.4 MALT (mucosa-associated lymphoid tissue) -- 9.4.1 Background and development -- 9.4.2 Sampling techniques -- 9.4.3 Artefacts -- 9.4.4 Anatomy and histology -- 9.5 Thymus -- 9.5.1 Background and development -- 9.5.2 Sampling techniques -- 9.5.3 Artefacts -- 9.5.4 Anatomy and histology -- 9.6 Bone marrow -- 9.6.1 Background and development -- 9.6.2 Sampling techniques -- 9.6.3 Artefacts -- 9.6.4 Anatomy and histology -- References -- Chapter 10 Integument and adipose tissue -- 10.1 Background and development -- 10.2 Sampling technique -- 10.3 Anatomy and histology -- 10.3.1 Nail -- 10.3.2 Mammary gland -- 10.3.3 Adipose tissue -- 10.3.4 Background lesions and artefacts -- References -- Chapter 11 The respiratory system -- 11.1 Background and development -- 11.2 Embryology -- 11.3 Anatomy and histology of the respiratory system -- 11.4 Upper respiratory tract -- 11.4.1 Sampling the nasal cavity -- 11.4.2 The nasal cavity -- 11.4.3 Lymphoid-associated tissue in the upper respiratory tract -- 11.4.4 The pharynx -- 11.4.5 The larynx -- 11.4.6 The trachea -- 11.4.7 Background lesions of the upper respiratory tract -- 11.5 Lower respiratory tract -- 11.5.1 Sampling techniques and morphometry of the lower respiratory tract -- 11.5.2 Lung -- 11.5.3 Background lesions in the lung -- References -- Chapter 12 Special senses -- 12.1 Background and development -- 12.2 Sampling technique for the eye -- 12.3 Artefacts -- 12.4 Anatomy and histology of the eye and associated glands -- 12.4.1 Eyelids -- 12.4.2 Sclera and cornea -- 12.4.3 Uvea -- 12.4.4 Lens.

12.4.5 Vitreous -- 12.4.6 Retina -- 12.4.7 Intraorbital glands -- 12.5 Background and development of the ear -- 12.6 Sampling technique for the ear and associated structures -- 12.7 Anatomy and histology of the ear and associated glands -- References -- Chapter 13 Musculoskeletal system -- 13.1 Background and development -- 13.2 Sampling techniques -- 13.3 Anatomy and histology -- 13.3.1 Bone -- 13.3.2 Muscle -- References -- Index.