Bone Morphogenetic Protein and Collagen : An Advances in Tissue Banking Specialist Publication.
Title:
Bone Morphogenetic Protein and Collagen : An Advances in Tissue Banking Specialist Publication.
Author:
Phillips, Glyn O.
ISBN:
9789812795298
Personal Author:
Physical Description:
1 online resource (169 pages)
Series:
Allografts in Bone Healing: Biology and Clinical Applications ; v.2
Allografts in Bone Healing: Biology and Clinical Applications
Contents:
CONTENTS -- Introduction to the Series -- Preface -- List of Contributors -- Chapter 1 From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction -- 1. Introduction -- 2. Bone Morphogenesis is a Cascade -- 3. Purification Cloning and Expression of Recombinant BMPs -- 4. BMPs and Chondrogenesis and Cartilage Maintenance -- 5. BMPs: Pleiotropy and Thresholds -- 6. BMP Receptors and Smads -- 7. BMPs: Clinical Applications -- 8. Acknowledgements -- 9. References -- Chapter 2 The Osteoinductive Properties of Demineralised Bone Matrix Grafts -- 1. Introduction -- 2. Factors Affecting the Osteoinductivity of DBM Grafts -- 3. Cellular Effects of DBM Grafts -- 4. The BMPs -- 5. DBM Grafts in Clinical Use -- 6. Assays For DBM Activity -- 7. References -- Chapter 3 Processing Factors Contributing To Production Of Maximally Osteoinductive Demineralised Ground Bone For Use In Orthopaedic Or Periodontal Applications -- 1. Introduction -- 2. Cleaning of Bone -- 3. Demineralization of Bone -- 4. Determination of Osteoinductive Potential of Bone -- 5. Summary and Conclusions -- 6. References -- Chapter 4 Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture -- 1. Introduction -- 2. Material and Methods -- 3. Results -- 4. Discussion -- 5. Acknowledgement -- 6. References -- Chapter 5 The Influence of Sterilisation on the Osteoinductive Properties of Bone in Rat Bone Marrow Cell Culture -- 1. Introduction -- 2. Materials and Methods -- 3. Result -- 4. Discussion -- 6. Acknowledgement -- 7. References -- Chapter 6 Collagen Biochemistry: An Overview -- 1. Introduction: What is "Collagen"? -- 2. Collagen Superfamily -- 3. Type I Collagen Biosynthesis -- 4. Collagen Cross-Linking -- 5. Other Post-Translational Modifications -- 6. Acknowledgements -- 7. References.
Abstract:
What are bone morphogenetic proteins (BMPs) and how can they be used in orthopaedic practice? Ever since Urist proposed in 1976 that protein factors from cortical bone appeared to modulate bone healing in animals, there has been a search for these mysterious osteoinductive components. Now that their structure has been elucidated, they have been purified and cloned, and are now available for the improvement of bone healing. The best source of BMPs is demineralised bone. This bone allograft is used to achieve greater osteoinductive capacity. But are the actions of procurement, processing, demineralisation and sterilisation harmful to the BMPs? Unless the BMPs can be assayed, neither their clinical nor their scientific effectiveness can be appraised. All these aspects are logically and scientifically described in this volume. In addition, there is a review of the biochemistry of one of the two main components of bone, namely collagen. This subject is itself a confusing but rapidly growing field. This comprehensive review describes the procedures for building up bone in vivo and in vitro . Bone Morphogenetic Protein and Collagen answers most of the questions of orthopaedic surgeons and tissue bankers on how BMPs can be produced and used to their maximum effectiveness. Contents: From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction; The Osteoinductive Properties of Demineralised Bone Matrix Grafts; Processing Factors Contributing to Production of Maximally Osteoinductive Demineralised Ground Bone; Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture; The Influence of Sterilisation on the Osteoinductive Properties of Bone in Rat Bone Marrow Cell Culture; Collagen Biochemistry: An Overview. Readership: Orthopaedic surgeons who use tissue allografts in bone and related reconstructions.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
Genre:
Electronic Access:
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