Contents -- Preface -- 1. A Brief History of Corneal Transplantation -- Ancient History -- The 18th and 19th Centuries -- The Early 20th Century -- The Modern Era -- References -- 2. Surgery of Corneal Graft in Humans -- Introduction -- Indications for Corneal Graft -- Surgical Factors Affecting Graft Outcome -- Types of Corneal Graft -- Complications of Corneal Graft Surgery -- Combined Surgical Procedures -- Conclusion -- References -- 3. The Clinical Problem -- Introduction -- Indications for Corneal Graft -- Contraindications for Corneal Graft -- Preoperative Work-up -- Complications of Corneal Graft Surgery Affecting Graft Survival -- Symptoms and Signs of Corneal Allograft Rejection in Humans -- Factors Affecting Clinical Rejection -- Conclusion -- References -- 4. Eye Banking -- Introduction -- History -- Criteria for Cornea Donation -- Procurement and Examination of Donor Corneas -- Techniques for Assessing Endothelial Cell Viability -- Methods of Corneal Preservation -- Future Developments -- References -- 5. MHC Antigens Tissue Typing and Blood Group Matching in Corneal Transplantation -- Introduction -- MHC Antigens -- Minor Histocompatibility Antigens -- Tissue Typing and HLA Matching -- Conclusion -- References -- 6. The Alloresponse to Corneal Graft -- Introduction -- Target Antigens in Graft Rejection-Alloantigens and Non-MHC Antigens -- The Cellular Response to Allografts-Direct vs Indirect Response -- Mechanism of Graft Rejection -- Ocular Immune Privilege -- Memory and Induction of Tolerance -- Conclusion -- References -- 7. The Xenoresponse to Corneal Graft -- Introduction -- The Immune Response to Xenografts -- The Immune Response to Corneal Xenografts -- The Use of Corneal Xenografts to Study Human Corneal Wound Healing -- Possible Systemic Complications of Xenografts -- Conclusion -- References.

8. Animal Models of Corneal Graft -- Introduction-Historical Note -- Value of Animal Models -- Types of Animal Model -- Clinical Criteria of Graft Rejection -- Conclusion -- References -- 9. Pathology of Human Corneal Transplantation -- Introduction -- Analysis of Paracentesis Samples During Graft Rejection -- Immunohistological Studies of Failed Corneal Grafts -- Adhesion Molecules and Human Corneal Grafts -- Conclusion -- References -- 10. Therapeutic Approach to Experimental Corneal Graft Rejection -- Introduction -- Strategies for Immunotherapy -- Drug Delivery -- Drug-Based Immunosuppressant Therapy -- Molecular Immunointervention -- Gene Therapy -- Conclusion -- References -- 11. Immunosuppression for Human Corneal Graft Rejection -- Introduction -- Immediate Postoperative Therapy for Corneal Grafts -- Management of Graft Rejection -- Conclusion -- References -- 12. Transmission of Disease Through Corneal Transplantation -- Introduction -- Bacterial and Fungal Disease -- Virus Disease -- Prion Disease -- Conclusion -- References -- 13. Artificial Corneas -- Introduction -- Biomaterials -- Indications for KPro -- Types of Keratoprosthesis -- Complications of KPros -- Human Corneal Functional Equivalents -- Conclusion -- References -- Index.