High-Throughput Analysis for Food Safety -- Contents -- Preface -- Contributors -- Chapter 1: Introduction: Basic Principles of Aassays to be Covered, Sample Handling, and Sample Processing -- 1.1 Introduction -- 1.1.1 Current Situation and Challenges of Food Safety and Regulations -- 1.1.2 Residues and Matrices of Food Analysis and High-Throughput Analysis -- 1.1.3 Food Safety Classifications -- 1.1.4 "High Throughput" Definition -- 1.1.5 Scope of the Book -- 1.2 Advanced Sample Preparation Techniques -- 1.2.1 Automation of Weighing and Preparing Standard Solutions -- 1.2.2 QuEChERS -- 1.2.3 Swedish Extraction Technique (SweEt) and Other Fast Sample Preparation Methods -- 1.2.4 Turbulent Flow Chromatography -- 1.2.5 Pressurized Liquid Extraction -- 1.2.6 Automated 96- and 384-Well Formatted Sample Preparation as well as Automated SPE Workstations -- 1.2.7 Solid-Phase Microextraction -- 1.2.8 Microextraction by Packed Sorbent -- 1.2.9 Liquid Extraction Surface Analysis -- 1.2.10 Headspace GC -- 1.2.11 Summary -- 1.3 Future Perspectives -- Acknowledgment -- References -- Chapter 2: Survey of Mass Spectrometry-Based High-Throughput Methods in Food Analysis -- 2.1 Introduction -- 2.2 Techniques Employing Chromatographic Separation -- 2.2.1 Gas Chromatography-Mass Spectrometry -- 2.2.2 Liquid Chromatography-Mass Spectrometry -- 2.3 Direct Techniques -- 2.3.1 Matrix-Assisted Laser Desorption/ Ionization-Mass Spectrometry -- 2.3.2 Headspace (Solid-Phase Microextraction)- Mass Spectrometry E-Nose -- 2.3.3 Ambient Desorption/Ionization-Mass Spectrometry -- 2.4 Concluding Remarks -- Acknowledgments -- References -- Chapter 3: Quality Systems, Quality Control Guidelines and Standards, Method Validation, and Ongoing Analytical Quality Control -- 3.1 Introduction -- 3.1.1 Quality System Design -- 3.1.2 Procedures -- 3.1.3 Roles and Responsibilities.

3.1.4 Quality Manual -- 3.1.5 Document Control -- 3.1.6 Control of Records -- 3.1.7 Audits -- 3.1.8 Validation of Methodology -- 3.1.9 Staff Competency -- 3.1.10 Internal Quality Control -- 3.1.11 Method Performance Criteria -- 3.2 Qualitative Screening Methods -- 3.2.1 Selectivity of Mass Spectrometry-Based Methods -- 3.2.2 Confirmatory Methods -- 3.2.3 Validation of Qualitative Screening Multiresidue Methods for Pesticide Residues in Foods -- 3.3 Elements of the Analytical Workflow -- 3.3.1 Sample Preparation -- 3.3.2 Effects of Sample Processing -- 3.3.3 Extraction Efficiency -- 3.4 Initial Method Validation -- 3.5 Ongoing Analytical Quality Control -- 3.5.1 Internal Quality Control -- 3.5.2 Proficiency Testing -- 3.6 Validation of Qualitative Screening Multiresidue Methods for Veterinary Drug Residues in Foods -- 3.6.1 EU Legislation Covering Method Validation for Veterinary Drug Screening -- 3.6.2 Determination of Specificity/Selectivity and Detection Capability (CCß) Using the Classical Approach -- 3.6.3 Establishment of a Cutoff Level and Calculation of CCβ -- 3.6.4 Determination of the Applicability -- 3.7 Conclusions -- References -- Chapter 4: Deliberate Chemical Contamination and Processing Contamination -- 4.1 Introduction -- 4.2 Heat-Induced Food Processing Contaminants -- 4.3 Packaging Migrants -- 4.4 Malicious Contamination of Food -- References -- Chapter 5: Multiresidual Determination of 295 Pesticides and Chemical Pollutants in Animal Fat by Gel Permeation Chromatography (GPC) Cleanup Coupled with GC-MS/MS, GC-NCI-MS, and LC-MS/MS -- 5.1 Introduction -- 5.1.1 Persistent Organic Pollutants -- 5.1.2 Polycyclic Aromatic Hydrocarbons -- 5.1.3 Polychlorinated Biphenyls -- 5.1.4 Phthalate Esters -- 5.1.5 Multiclass and Multiresidue Analyses -- 5.2 Experiment -- 5.2.1 Instruments -- 5.2.2 Reagents.

5.2.3 Preparation of Standard Solutions -- 5.2.4 Sample Preparation -- 5.2.5 Analytical Methods -- 5.2.6 Qualitative and Quantitative Determination -- 5.3 Results and Discussion -- 5.3.1 Selection of GPC Cleanup Conditions -- 5.3.2 Selection of Extraction Solvent -- 5.3.3 Comparison of Sample Extraction Methods -- 5.3.4 Comparison of Sample Cleanup -- 5.3.5 Linear Range, LOD, and LOQ -- 5.3.6 Recoveries and Precisions -- 5.3.7 Actual Sample Analysis -- 5.4 Conclusions -- References -- Chapter 6: Ultrahigh-Performance Liquid Chromatography Coupled with High-Resolution Mass Spectrometry: A Reliable Tool for Analysis of Veterinary Drugs in Food -- 6.1 Introduction -- 6.2 Veterinary Drug Legislation -- 6.3 Analytical Techniques for VD Residue Analysis -- 6.3.1 Chromatographic Separation -- 6.3.2 High-Resolution Mass Spectrometers -- 6.4 Food Control Applications -- 6.4.1 Screening Applications -- 6.4.2 Confirmation and Quantification Methods -- 6.4.3 Comparison Studies -- 6.5 Conclusions and Future Trends -- Acknowledgments -- References -- Chapter 7: A Role for High-Resolution Mass Spectrometry in The High-Throughput Analysis and Identification of Veterinary Medicinal Product Residues and of Their Metabolites in Foods of Animal Origin -- 7.1 Introduction -- 7.2 Issues Associated with Veterinary Drug Residues and European Regulations -- 7.3 Choosing a Strategy: Targeted or Nontargeted Analysis? -- 7.3.1 Targeted Analysis Using HRMS -- 7.3.2 Nontargeted Analysis Using HRMS: Screening for Unknown Compounds -- 7.4 Application Number 1: Identification of Brilliant Green and its Metabolites in Fish under High-Resolution Mass Spectral Conditions (Targeted and Nontargeted Approaches) -- 7.5 Application Number 2: Targeted and Nontargeted Screening Approaches for the Identification of Antimicrobial Residues in Meat -- 7.6 Conclusions -- References.

Chapter 8: High-Throughput Analysis of Mycotoxins -- 8.1 Introduction -- 8.1.1 Legislation and Regulatory Limits -- 8.1.2 Emerging Mycotoxins -- 8.1.3 Analysis of Mycotoxins in the High-Throughput Environment -- 8.2 Sample Preparation -- 8.2.1 Sampling -- 8.2.2 Matrices of Interest -- 8.2.3 Extraction of Mycotoxins -- 8.2.4 Purification of Sample Extracts -- 8.3 Separation and Detection of Mycotoxins -- 8.3.1 Liquid Chromatography-Mass Spectrometry-Based Methods -- 8.3.2 High-Resolution Mass Spectrometry in Mycotoxins Analysis -- 8.4 No-Separation Mass Spectrometry-Based Methods -- 8.4.1 Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry -- 8.4.2 Ambient Ionization Mass Spectrometry -- 8.4.3 Ion Mobility Spectrometry -- 8.4.4 Immunochemical Methods -- 8.5 Conclusions -- Acknowledgments -- References -- Index -- Series Page -- End User License Agreement.