Cover -- Title page -- Copyright page -- Contents -- Preface to the third edition -- Preface to the first edition -- CHAPTER 1: Introduction -- Reasons for performing bone marrow biopsies -- How to examine a trephine section -- References -- CHAPTER 2: The normal bone marrow -- Site of haematopoiesis -- Components of the normal bone marrow trephine -- Bone -- Stroma -- Haematopoietic tissue -- Other cells -- References -- CHAPTER 3: Infections including human immunodeficiency virus -- Bacterial infection -- Viral infection -- HIV infection -- Clinical features -- Histopathology of the bone marrow -- Reactive features -- Secondary infections -- Malignancies -- Diagnostic problems -- Reference -- CHAPTER 4: Anaemias and aplasias -- Anaemias -- Iron deficiency anaemia -- Copper deficiency anaemia -- Anaemia of chronic disease -- Haemolytic anaemia -- Megaloblastic anaemia -- Congenital dyserythropoietic anaemias -- Aplasias -- Acquired aplastic anaemias -- Congenital aplastic anaemias -- References -- CHAPTER 5: The myelodysplastic syndromes -- Myelodysplasia -- Clinical features -- Histopathology of the bone marrow -- Cellularity -- Abnormalities of marrow architecture -- Dysmegakaryopoiesis -- Dyserythropoiesis -- Dysgranulopoiesis -- Abnormally located immature precursors -- Histological correlation with the WHO and FAB classifications -- Chronic myelomonocytic leukaemia -- Clinical features -- Diagnosis -- Histopathology of the bone marrow -- Diagnostic problems -- Differential diagnosis -- Secondary MDS -- Overlap between myelodysplasia and myeloproliferation -- References -- CHAPTER 6: Myeloproliferative neoplasms -- Classification of MPN -- Chronic myeloid leukaemia -- Clinical features -- Histopathology of the bone marrow -- Diagnostic problems -- Polycythaemia vera -- Clinical features -- Histopathology of the bone marrow.

Diagnostic problems -- Essential thrombocythaemia -- Clinical features -- Histopathology of the bone marrow -- Diagnostic problems -- Primary myelofibrosis -- Clinical features -- Histopathology of the bone marrow -- Acute myelofibrosis -- Diagnostic difficulties -- Mast cell disease -- Histopathology of the bone marrow -- Differential diagnosis -- Transient myeloproliferative disorder -- Myeloproliferative neoplasms with eosinophilia and rearrangements of PDGFRA, PDGFRB or FGFR1 -- References -- CHAPTER 7: Acute leukaemia -- Classification -- Acute myeloid leukaemia -- Classification -- Histopathology and immunophenotyping -- Diagnostic problems -- Acute lymphoblastic leukaemia -- Transplantation and post-transplantation lymphoproliferative disorders -- References -- CHAPTER 8: Lymphomas: an overview -- What does the clinician require from the pathologist? -- B cell neoplasms in the WHO classification -- Precursor B-cell neoplasm -- Mature B-cell neoplasms -- T cell and natural killer cell neoplasms in the WHO classification -- Hodgkin lymphoma -- References -- CHAPTER 9: Precursor B and T lymphoblastic leukaemia (acute lymphoblastic leukaemia) and lymphoblastic lymphoma -- Histopathology of the bone marrow -- Cytogenetics of B lymphoblastic leukaemia/lymphoma -- Cytogenetics of T lymphoblastic leukaemia/lymphoma -- Diagnostic problems -- Sparse infiltrate -- Distinction from chronic lymphocytic leukaemia -- Distinction from AML -- Detection of early disease and relapse -- References -- CHAPTER 10: Mature B cell neoplasms -- Chronic lymphocytic leukaemia/small lymphocytic lymphoma incorporating B cell and T cell prolymphocytic leukaemia -- Clinical features -- Histopathology of the bone marrow -- Genetics -- Diagnostic problems -- References -- Lymphoplasmacytic lymphoma including Waldenström's macroglobulinaemia -- Histopathology of the bone marrow.

References -- Mantle cell lymphoma -- Histopathology of the bone marrow -- Cytogenetics -- Diagnostic problems -- References -- Follicular lymphoma -- Histopathology of the bone marrow -- Diagnostic problems -- Cytogenetics and molecular biological features -- The effect of rituximab treatment -- References -- Marginal zone B-cell lymphoma (including MALT type) -- Clinical features -- Histopathology of the bone marrow -- Diagnostic problems -- References -- Hairy cell leukaemia -- Clinical features -- Histopathology of the bone marrow -- Patterns of involvement -- Diagnostic problems -- Hairy cell leukaemia variant -- References -- Multiple myeloma -- Clinical features -- Histopathology of the bone marrow -- Immunophenotype -- Cytogenetics -- Less common appearances -- Other features occasionally seen in association with myeloma -- Diagnostic problems -- References -- Diffuse large B cell lymphoma -- Histopathology of the bone marrow -- Cytogenetics -- Diagnostic problems -- References -- Burkitt lymphoma -- Histopathology of the bone marrow -- Cytogenetics -- Diagnostic problems -- Necrotic tumours -- CHAPTER 11: Mature T and NK cell neoplasms -- T-cell large granular lymphocytic leukaemia -- Histopathology of the bone marrow -- Immunophenotype -- Aggressive NK cell leukaemia -- Clinical features -- Histology -- Immunophenotype -- Cytogenetics -- Prognosis and treatment -- References -- Cutaneous T cell lymphoma -- General features -- Histopathology of the bone marrow -- Diagnostic problems -- Reference -- Peripheral T cell lymphomas, not otherwise specified -- Histopathology of the bone marrow -- Diagnostic problems -- Hepatosplenic T cell lymphoma -- Histopathology of the bone marrow -- Diagnostic problems -- Angio-immunoblastic T cell lymphoma -- Histopathology of the bone marrow -- Diagnostic problems -- Adult T cell lymphoma/leukaemia.

Histopathology of the bone marrow -- Diagnostic problems -- Anaplastic large cell lymphoma -- ALCL ALK-positive -- Histopathology of the bone marrow -- Immunophenotype -- Diagnostic problems -- Cytogenetics -- ALCL ALK-negative -- References -- CHAPTER 12: Hodgkin lymphoma -- Clinical features -- Histopathology of the bone marrow -- Diagnostic problems -- CHAPTER 13: Metastatic disease -- Clinical features -- Histopathology of the bone marrow -- Carcinoma -- Paediatric tumours -- Diagnostic problems -- Other fibrosing conditions -- Reference -- CHAPTER 14: Bone, stroma and miscellaneous changes -- Bone -- Osteoporosis -- Hyperparathyroidism -- Renal osteodystrophy -- Paget's disease -- Osteopetrosis -- Stroma -- Fibrosis -- Lymphoid nodules -- Granulomas -- Serous atrophy -- Vasculitis -- Foamy macrophages -- Miscellaneous changes -- Amyloidosis -- Immune thrombocytopenic purpura -- Thrombotic thrombocytopenic purpura -- Erythrophagocytosis -- Haemosiderin -- Necrosis -- The effects of drugs and chemicals -- References -- CHAPTER 15: Technical considerations -- Preparation of bone marrow biopsies -- Fixation and decalcification -- Aspirates -- Trephines -- Processing and embedding -- Staining of bone marrow biopsies -- Giemsa stain -- Immunohistochemistry -- The value of immunostaining methods -- Antibodies for diagnostic use and the CD system -- Index -- EULA.